Special Issue "Isolation, Determination and Analysis of Bioactive Natural Sulfur Compounds"

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: 31 December 2021.

Special Issue Editor

Dr. Antonio Francioso
E-Mail Website
Guest Editor
Department of Biochemical Sciences, Sapienza University, p.le Aldo Moro, 5, 00185 Rome, Italy
Interests: natural product isolation and identification; chromatography; mass spectrometry; bio-organic and green chemistry; sulfur-containing compounds; polyphenols; iridoids and phenolic secoiridoids; c-glycosyl secondary metabolites; neurochemistry; anti-inflammatory and neuroprotective compounds

Special Issue Information

Dear Colleagues,

Sulfur-containing products contribute significantly to natural chemical diversity and allow fundamental biological functions that no other compounds allow. Natural sulfur compounds are utilized by all living beings and are distributed in the different kingdoms depending on their role. Marine organisms are one of the most important sources of sulfur-containing natural products since most of the inorganic sulfur is metabolized in ocean environments where this element is abundant. Terrestrial and marine organisms such as plants and microorganisms are also able to incorporate sulfur into organic molecules to produce primary metabolites (e.g., methionine, cysteine) and more complex unique chemical structures with diverse biological roles (e.g., glucosinolates, ergothioneine, ovothiols). Animals are not able to fix inorganic sulfur into biomolecules and are completely dependent on preformed organic sulfurous compounds to satisfy their sulfur needs. However, some higher species such as humans are able to build new sulfur-containing chemical entities starting especially from the organosulfur precursors of plants. The aim of this Special Issue is to provide fundamental and new research works on sulfur compound separations at the preparative and analytical scale as well as new findings in bioactive natural sulfur products.

Dr. Antonio Francioso
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Natural sulfur compounds
  • Chromatography
  • Extraction, isolation and purification
  • Preparative and analytical separations
  • Bioactive sulfur products

Published Papers (2 papers)

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Research

Communication
Fluorometric Optimized Determination of Total Glutathione in Erythrocytes
Separations 2021, 8(6), 83; https://doi.org/10.3390/separations8060083 - 13 Jun 2021
Viewed by 665
Abstract
Glutathione is a tripeptide natural product characterized by a non-canonical peptide bond with an amide moiety linking the nitrogen of cysteine to the γ-carboxyl of glutamate, and is found ubiquitously in nature, in animals, plants and microorganisms. One of the most abundant biological [...] Read more.
Glutathione is a tripeptide natural product characterized by a non-canonical peptide bond with an amide moiety linking the nitrogen of cysteine to the γ-carboxyl of glutamate, and is found ubiquitously in nature, in animals, plants and microorganisms. One of the most abundant biological matrices is represented by erythrocytes, being glutathione the only sulfur-containing mechanism for the red blood cell oxidative protection. Several analytical methods for glutathione determination from different samples are described in the literature and most of these methods are based on the use of high-performance liquid chromatography. HPLC equipment is not available in all the biochemical laboratories, and, moreover, displays lot of economic and ecological limitations, including organic solvent consumption and time-consuming analysis. Here, an organic-free high-throughput fluorometric methodology for the analysis of total glutathione in erythrocytes is reported, avoiding the use of time-consuming and not-sustainable techniques. Full article
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Article
Analysis of Unusual Sulfated Constituents and Anti-infective Properties of Two Indonesian Mangroves, Lumnitzera littorea and Lumnitzera racemosa (Combretaceae)
Separations 2021, 8(6), 82; https://doi.org/10.3390/separations8060082 - 10 Jun 2021
Viewed by 704
Abstract
Lumnitzera littorea and Lumnitzera racemosa are mangrove species distributed widely along the Indonesian coasts. Besides their ecological importance, both are of interest owing to their wealth of natural products, some of which constitute potential sources for medicinal applications. We aimed to discover and [...] Read more.
Lumnitzera littorea and Lumnitzera racemosa are mangrove species distributed widely along the Indonesian coasts. Besides their ecological importance, both are of interest owing to their wealth of natural products, some of which constitute potential sources for medicinal applications. We aimed to discover and characterize new anti-infective compounds, based on population-level sampling of both species from across the Indonesian Archipelago. Root metabolites were investigated by TLC, hyphenated LC-MS/MS and isolation, the internal transcribed spacer (ITS) region of rDNA was used for genetic characterization. Phytochemical characterization of both species revealed an unusual diversity in sulfated constituents with 3,3’,4’-tri-O-methyl-ellagic acid 4-sulfate representing the major compound in most samples. None of these compounds was previously reported for mangroves. Chemophenetic comparison of L. racemosa populations from different localities provided evolutionary information, as supported by molecular phylogenetic evidence. Samples of both species from particular locations exhibited anti-bacterial potential (Southern Nias Island and East Java against Gram-negative bacteria, Halmahera and Ternate Island against Gram-positive bacteria). In conclusion, Lumnitzera roots from natural mangrove stands represent a promising source for sulfated ellagic acid derivatives and further sulfur containing plant metabolites with potential human health benefits. Full article
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