Analysis and Bioanalysis of Pharmaceuticals: Sample Preparation and Chromatography

Dear Colleagues,

It is widely recognized that pharmaceutical analysis plays a pivotal role not only in the quality control of pharmaceutical products but also in the development of original or generic formulations. Simultaneously, pharmaceutical bioanalysis stands out as an indispensable tool in pharmacokinetic and therapeutic drug monitoring studies. In both pharmaceutical analysis and bioanalysis, chromatography is a predominant analytical technique that has been widely practiced for decades.

Innovative breakthroughs, including ultra-performance thin-layer chromatography (HPTLC), ultra-high-pressure liquid chromatography (UHPLC), and hyphenated techniques like gas chromatography–mass spectrometry (GC-MS) and liquid chromatography–mass spectrometry (LC–MS) or two-dimensional liquid chromatography (2D-LC), chiral separations, core–shell columns, and novel stationary phases, have collectively improved chromatography, permitting faster speed, higher resolution, greater sensitivity, and increased precision.

Unquestionably, sample preparation also constitutes a critical facet of the analytical process. Recent advances introduced by the development of novel technologies and sorbents have substantially enhanced the performance of sample preparation techniques.

This Special Issue is dedicated to original research publications applying optimized extraction techniques to molecules of significant biopharmaceutical interest from various matrices and their quantification using chromatographic techniques coupled with sensitive detectors. Moreover, the scope extends to review papers that present an exhaustive examination of the state of the art in chromatographic analysis and bioanalysis concerning specific active pharmaceutical ingredients.

Dr. Anne Marie Ciobanu
Prof. Dr. Daniela Baconi
Prof. Dr. George Traian Alexandru Burcea-Dragomiroiu
Dr. Carmen Lidia Chitescu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.