Special Issue "Understanding eQTL impact on postmortem brain gene expression in mental disorders across different populations"
A special issue of Psych (ISSN 2624-8611).
Deadline for manuscript submissions: closed (30 September 2019).
2. Department of Physiology and Biophysics, Center for Biomarker Research and Precision Medicine, School of Pharmacy, Virginia Commonwealth University, 907 Floyd Ave, Richmond, VA 23284, USA
3. Lieber Institute for Brain Development, Johns Hopkins University, Baltimore, MD 21218, USA
Interests: GWAS; miRNA; eQTLs; gene expression; postmortem brain espression studies
Special Issues and Collections in MDPI journals
In the last decade, a massive and concerted effort from the research community has led to a generation of large ‘mega’ genome-wide association scans (GWAS) that have analyzed millions of genotyped and imputed single nucleotide polymorphisms (SNP) generated from hundreds of thousands of people. This, in turn, has led to the identification of robust and replicable genetic variants associated with severe neuropsychiatric phenotypes, such as schizophrenia (SZ), bipolar disorder (BP), and major depressive disorders (MDD) and, more recently, externalizing disorders related to alcohol and cannabis use. However, a major limitation of these ‘mega’-GWAS is the lack of: (1) Ethnic diversity and (2) an understanding the neuropathological mechanisms by which risk variants contribute to disease.
Thus, the goal of this Special Issue is to invite original research aiming to integrate GWAS and gene expression data generated in postmortem brain tissues from patients diagnosed with (but not limited to) SZ, BP, and MDD, and substance abuse disorders, across different populations, to better understand the neurobiological mechanisms by which risk GWAS loci contribute to disease pathology. Understanding how these loci (termed expression quantitative trait loci (eQTL)) contribute to disease neuropathology will increase our knowledge of the etiopathology of these severe mental disorders across different populations, and it may further offer novel approaches for disease treatment that is also specific to individual populations.
Dr. Vladimir Vladimirov
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- Mental disorders
- Postmortem brain tissue
- Gene expression