Special Issue "Fostering Systems Engineering and Control in Systems and Synthetic Biology"

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Biological Systems".

Deadline for manuscript submissions: 4 May 2020.

Special Issue Editors

Prof. Jesús Picó
E-Mail Website
Guest Editor
Instituto de Automática e Informática Industrial, Building 5C, Universitat Politècnica de València, Camí de Vera s/n, 46022-València, Spain
Interests: sliding mode observers for bioprocess estimation; nonlinear adaptive control of bioreactors; feedback control of gene synthetic circuits; robust estimation of metabolic fluxes; multiobjective optimization in systems and synthetic biology; the design, build, test, and learn cycle in synthetic biology; synthetic biology for production of metabolites of interest
Special Issues and Collections in MDPI journals
Prof. Steffen Waldherr
E-Mail Website
Guest Editor
Katholieke Universiteit Leuven, Leuven, Belgium
Interests: Modelling of biological systems, Robustness analysis of biological networks, Modelling and analysis of heterogeneous cell populations, Dynamic optimization of metabolic networks
Special Issues and Collections in MDPI journals
Dr. Alejandro Vignoni
E-Mail Website
Guest Editor
Instituto de Automática e Informática Industrial, Building 5C, Universitat Politècnica de València, Camí de Vera s/n, 46022-València (Spain)
Interests: design, build, test, and learn cycle in synthetic biology; multiobjective optimization for the design, build, and learn parts of the cycle; genetic circuits design and control; measurement standardization and part characterization in synthetic biology; modelling of cell polarity and morphogenesis; gene circuits design for personalized cancer therapy; coordination, consensus, and synchronization in biological systems; sliding modes control; biotechnology processes modeling, monitoring, and control

Special Issue Information

Dear Colleagues,

Computational and engineering methods are at the core of systems biology and synthetic biology. On the one hand, systems biology, by integrating quantitative data from a variety of sources, together with model inference and systems analysis techniques, has proven valuable in deciphering biological systems ranging from intracellular mechanisms to human disease. On the other hand, synthetic biology, defined as the engineering of biology, aims at making the engineering of biology easier, faster, and more predictable. To this end, it draws on principles elucidated from feedback control theory to achieve a robust performance in its quest to (re)design and construct novel biological devices and systems to perform new functions for useful purposes. Both are, thus, truly interdisciplinary disciplines with a convergence of expertise from biology, engineering, physics, computer science, and statistics. Many application areas, including industrial biotechnology and bioenergy, chemicals, medicine, agriculture, and environmental remediation may potentially benefit from them.

This Special Issue on “Systems Engineering and Control in Systems and Synthetic Biology” aims at showing the most recent advances in the application of systems engineering and feedback control methods in these two emerging fields. The latest research is being shown and discussed at the 8th IFAC Conference on Foundations of Systems Biology in Engineering (FOSBE2019) held in València, Spain on 15–18 October, 2019. The issue is a reflection of high-quality papers presented at FOSBE2019. Topics include but are not limited to:

  • Modelling of complex biological systems;
  • Multiscale and multi-omics data integration and modeling;
  • Network inference and modeling (signaling, regulation, metabolic);
  • Analysis and modelling of stochastic and heterogeneous systems;  
  • Dynamics and control of biological systems;
  • Design and control of synthetic biological systems and circuits;
  • Systems biology for (red, green, blue, and white) biotechnology;
  • Systems medicine;
  • Synthetic biology;
  • Next-generation methods and tools for systems and synthetic biology.

Prof. Jesús Picó
Prof. Steffen Waldherr
Dr. Alejandro Vignoni
Guest editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Please note that for papers submitted after 30 June 2020 an APC of 1500 CHF applies. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • synthetic biology
  • systems biology
  • systems engineering
  • feedback control
  • system dynamics
  • modeling and optimization

Published Papers

This special issue is now open for submission.
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