Special Issue "Special Issue in Honor of Retired Professor and Former Dean Dr. Kishor M. Wasan: The Current State of Pharmaceutical Sciences and Its Promising Future"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 31 October 2022.

Special Issue Editors

Dr. Emmanuel Ho
E-Mail Website
Guest Editor
Laboratory for Drug Delivery and Biomaterials, School of Pharmacy, University of Waterloo, Kitchener, ON N2G 1C5, Canada
Interests: nanoparticles; surfactants; medical devices; HIV/AIDS; wound healing; cancer
Special Issues, Collections and Topics in MDPI journals
Dr. Pavel Gershkovich
E-Mail Website
Guest Editor
School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

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Prof. Dr. Kishor M. Wasan

Dear Colleagues,

This commemorative Special Issue of Pharmaceutics is in honour of Professor Kishor M Wasan’s remarkable contributions to the pharmaceutics field.

Professor Wasan has published over 300 peer-reviewed articles and other published contributions as well as 300 abstracts in the areas of lipid-based drug delivery, lipoprotein-drug interactions, neglected global diseases, and cancer therapy. He is the co-founder of the Neglected Global Diseases Initiative at the University of British Columbia. Professor Wasan has won multiple prestigious national and international awards for his impact on drug delivery and is a Fellow of the American Association of Pharmaceutical Scientists, Fellow of the Canadian Society for Pharmaceutical Sciences, and of the Canadian Academy of Health Sciences.

Professor Wasan is currently a Distinguished University Scholar Adjunct Professor in the Department of Urologic Sciences, Faculty of Medicine at the University of British Columbia. He is also the Chief Medical/Scientific Officer at Skymount Medical and Director of Research at iCo Therapeutics Inc.

Most recently, Professor Wasan served as the Dean of the College of Pharmacy and Nutrition at the University of Saskatchewan from August 2014 to June 2019. Prior to this appointment, Professor Wasan served as an Associate Dean, Research and Graduate Studies, at the Faculty of Pharmaceutical Sciences, University of British Columbia. He has also led a research team at the University of British Columbia towards the development of an oral formulation of amphotericin B which has successfully completed phase I clinical trials.

In honor and recognition of Professor Kishor M Wasan’s outstanding contributions to this field, this Special Issue welcomes the submission of original research manuscripts or reviews in the area of pharmaceutical sciences. Manuscripts will be published online on an ongoing basis after being processed.

Dr. Emmanuel Ho
Dr. Pavel Gershkovich
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

Article
Inclusion of Medium-Chain Triglyceride in Lipid-Based Formulation of Cannabidiol Facilitates Micellar Solubilization In Vitro, but In Vivo Performance Remains Superior with Pure Sesame Oil Vehicle
Pharmaceutics 2021, 13(9), 1349; https://doi.org/10.3390/pharmaceutics13091349 - 27 Aug 2021
Cited by 2 | Viewed by 880
Abstract
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption of CBD. In this work, the performance of lipid-based formulations with [...] Read more.
Oral sesame oil-based formulation facilitates the delivery of poorly water-soluble drug cannabidiol (CBD) to the lymphatic system and blood circulation. However, this natural oil-based formulation also leads to considerable variability in absorption of CBD. In this work, the performance of lipid-based formulations with the addition of medium-chain triglyceride (MCT) or surfactants to the sesame oil vehicle has been tested in vitro and in vivo using CBD as a model drug. The in vitro lipolysis has shown that addition of the MCT leads to a higher distribution of CBD into the micellar phase. Further addition of surfactants to MCT-containing formulations did not improve distribution of the drug into the micellar phase. In vivo, formulations containing MCT led to lower or similar concentrations of CBD in serum, lymph and MLNs, but with reduced variability. MCT improves the emulsification and micellar solubilization of CBD, but surfactants did not facilitate further the rate and extent of lipolysis. Even though addition of MCT reduces the variability, the in vivo performance for the extent of both lymphatic transport and systemic bioavailability remains superior with a pure natural oil vehicle. Full article
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