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Pharmaceutics
Special Issues
Advances in Biopolymer-Based Drug Delivery System
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Special Issue "Advances in Biopolymer-Based Drug Delivery System"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 April 2023 | Viewed by 668

Special Issue Editors

Dr. Sougata Jana

E-Mail Website
Guest Editor
1. Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol 713301, India
2. Department of Health and Family Welfare, Directorate of Health Services, Kolkata 700091, India
Interests: biopolymer; modification of synthetic and natural biopolymers; polysaccharides; hydrogel; micelle; microparticulate; nanotechnology; inter-penetrating polymer network (IPN); polymer-grafting; polyelectrolyte complex; drug delivery; microparticles; nanomaterials; semisolids and interpenetrating network (IPN); pharmaceutical technology
Dr. John G. Hardy

E-Mail Website
Guest Editor
1. Department of Chemistry, Faraday Building, Lancaster University, Lancaster LA1 4YB, Lancashire, UK
2. Materials Science Institute, Faraday Building, Lancaster University, Lancaster LA1 4YB, Lancashire, UK
Interests: polymer synthesis; supramolecular materials; biomaterials; stimuli-responsive materials; drug delivery; tissue engineering; sustainability
Special Issues, Collections and Topics in MDPI journals
Dr. Subrata Jana

E-Mail Website
Guest Editor
Department of Chemistry, Indira Gandhi National Tribal University (Central University), Amarkantak, Madhya Pradesh 484886, India
Interests: biomaterials; biomedical engineering; chemistry; drug delivery; pharmaceutical science; polymers; polysaccharides; proteins; silk; tissue engineering; regenerative medicine

Special Issue Information

Dear Colleagues,

Biopolymer-based nanostructures or microstructures can be fabricated with different compositions, structures, and properties so that biopolymeric delivery systems can be tailored for specific applications. These structures can be assembled using various approaches, including electrospinning, coacervation, nanoprecipitation, injection, layer-by-layer deposition, and/or gelation. A major application of biopolymer-based particles is to encapsulate, protect, and release active molecules in the pharmaceutical sectors.

This Special Issue aims to combine articles describing biopolymer-based delivery systems, including biological applications, such as target specific drug delivery, gene delivery, cancer therapy, tissue engineering, bioimaging, and theranostics.

Dr. Sougata Jana
Dr. John G. Hardy
Dr. Subrata Jana
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biopolymer
  • polysaccharides
  • drug delivery
  • controlled release
  • hydrogel
  • micelle
  • microneedles
  • inter-penetrating polymer network (IPN)
  • polymer-grafting
  • polyelectrolyte complex
  • 3D-printing devices
  • tissue engineering
  • theranostics

Published Papers (1 paper)

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Article
A Novel Approach for the Fabrication of 3D-Printed Dental Membrane Scaffolds including Antimicrobial Pomegranate Extract
by
Hatice Karabulut
,
Songul Ulag
,
Basak Dalbayrak
,
Elif Damla Arisan
,
Turgut Taskin
,
Mehmet Mucahit Guncu
,
Burak Aksu
,
Alireza Valanezhad
and
Oguzhan Gunduz
Pharmaceutics 2023, 15(3), 737; https://doi.org/10.3390/pharmaceutics15030737 - 22 Feb 2023
Viewed by 452
Abstract
In this study, a dental membrane scaffold was fabricated using a 3D printing technique, and the antimicrobial effect of pomegranate seed and peel extract were investigated. For the production of the dental membrane scaffold, a combination of polyvinyl alcohol, starch, and pomegranate seed [...] Read more.
In this study, a dental membrane scaffold was fabricated using a 3D printing technique, and the antimicrobial effect of pomegranate seed and peel extract were investigated. For the production of the dental membrane scaffold, a combination of polyvinyl alcohol, starch, and pomegranate seed and peel extracts was used. The aim of the scaffold was to cover the damaged area and aid in the healing process. This can be achieved due to the high antimicrobial and antioxidant content of pomegranate seed and peel extracts (PPE: PSE). Moreover, the addition of starch and PPE: PSE improved the biocompatibility of the scaffold, and their biocompatibility was tested using human gingival fibroblast (HGF) cells. The addition of PPE: PSE into the scaffolds resulted in a significant antimicrobial effect on S. aureus and E. faecalis bacteria. Moreover, different concentrations of starch (1%, 2%, 3% w/v) and pomegranate peel and seed extract (3%, 5%, 7%, 9%, and 11% PE v/v) were analyzed to obtain the ideal dental membrane structure. The optimum starch concentration was chosen as 2% w/v due to it giving the scaffold the highest mechanical tensile strength (23.8607 ± 4.0796 MPa). The pore sizes of each scaffold were studied by SEM analysis, and pore sizes were arranged between 155.86 and 280.96 μm without any plugging problems. Pomegranate seed and peel extracts were obtained by applying the standard extraction method. High-performance liquid chromatography was performed using the diode-array detection (HPLC-DAD) technique to analyze the phenolic content of the pomegranate seed and peel extracts. Two phenolic components of the pomegranate seed and peel extracts were investigated in the following amounts: fumaric acid (17.56 μg analyte/mg extract) and quinic acid (18.79 μg analyte/mg extract) in pomegranate seed extract and fumaric acid (26.95 μg analyte/mg extract) and quinic acid (33.79 μg analyte/mg extract) in pomegranate peel extract. Full article
(This article belongs to the Special Issue Advances in Biopolymer-Based Drug Delivery System)
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