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Special Issue "Development of Lipid Nano-Pharmaceutical Formulations for Oral/Dermal/Transdermal Delivery"

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A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 October 2023 | Viewed by 3165

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Special Issue Editors

Dr. Abdul Ahad

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Guest Editor

Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Interests: drug delivery; lipid based formulations; vesicles formulations; solubility enhancement
Special Issues, Collections and Topics in MDPI journals

Dr. Yousef A. Bin Jardan

E-Mail Website
Guest Editor

Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Interests: drug delivery; oral formulation; controlled release systems; nanoparticles; novel drug delivery systems

Special Issue Information

Dear Colleagues,

In most cases, oral drug delivery is most preferred as it is convenient, non-invasive, and easy to incorporate into a patient's lifestyle. Nevertheless, several factors, including poor solubility, low dissolution rate, stability, and bioavailability of many dugs remain a constant challenge in achieving the desired therapeutic targets. The delivery of drugs must overcome various obstacles, including the acidic gastric environment and the presence of intestinal efflux and influx transporters.

On the other hand, dermal/transdermal drug delivery candidates have increased in recent years in response to the development of new and optimized approaches to improve local and systemic drug delivery. Dermal/transdermal delivery of drugs represents an effective method to deliver drugs directly to the site of action or to enhance treatment activity noninvasively. They circumvent the hepatic first passage and reduce toxicity. Several new technologies have opened up new horizons in this area and have emerged as attractive administration methods.

Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs.

This Special Issue is addressed to those authors who are currently engaged in research on the use of lipid-based formulations for the development of oral and dermal/transdermal drug delivery systems. Both research and review papers on oral and dermal/transdermal drug delivery systems are invited for this Special Issue.

This Special Issue aims to collect recent advances, developments, and future prospects on the design, development, characterization, and biological evaluation of lipid pharmaceutical formulations for oral/dermal/transdermal delivery, which may include but is not exclusively limited to articles on: dermal delivery; drug delivery systems; iontophoresis; liposomes; microneedles; nanocarriers; nanoemulsions; nanoparticles; nanostructured lipid carriers; niosomes; oral administration; permeation enhancers; polymeric nanoparticles; self-nanoemulsifying drug delivery systems; solid lipid nanoparticles; sonophoresis; transdermal delivery; vesicular systems.

Dr. Abdul Ahad
Dr. Yousef A. Bin Jardan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

dermal delivery
drug delivery systems
iontophoresis
liposomes
microneedles
nanocarriers
nanoemulsions
nanoparticles
nanostructured lipid carriers
niosomes
oral administration
permeation enhancers
polymeric nanoparticles
self-nanoemulsifying drug delivery systems
solid lipid nanoparticles
sonophoresis
transdermal delivery
vesicular systems

Published Papers (3 papers)

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Research

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Open AccessArticle

Preparation and Characterization of Transethosome Formulation for the Enhanced Delivery of Sinapic Acid

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Pharmaceutics 2023, 15(10), 2391; https://doi.org/10.3390/pharmaceutics15102391 - 27 Sep 2023

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Abstract

Sinapic acid (SA) is a bioactive phenolic acid; its diverse properties are its anti-inflammatory, antioxidant, anticancer, and antibacterial activities. The bioactive compound SA is poorly soluble in water. Our goal was to formulate SA-transethosomes using thin-film hydration. The prepared formulations were examined for various parameters. In addition, the optimized formulation was evaluated for surface morphology, in-vitro penetration studies across the Strat M^®, and its antioxidant activity. The optimized formulation (F5) exhibited 74.36% entrapment efficacy. The vesicle size, zeta potential, and polydispersity index were found to be 111.67 nm, −7.253 mV, and 0.240, respectively. The surface morphology showed smooth and spherical vesicles of SA-transethosomes. In addition, the prepared SA-transethosomes exhibited enhanced antioxidant activity. The SA-transethosomes demonstrated considerably greater penetration across the Strat M^® membrane during the study. The flux of SA and SA-transethosomes through the Strat M^® membrane was 1.03 ± 0.07 µg/cm²/h and 2.93 ± 0.16 µg/cm²/h. The enhancement ratio of SA-transethosomes was 2.86 ± 0.35 compared to the control. The SA-transethosomes are flexible nano-sized vesicles and are able to penetrate the entrapped drug in a higher concentration. Hence, it was concluded that SA-transethosome-based approaches have the potential to be useful for accentuating the penetrability of SA across the skin. Full article

(This article belongs to the Special Issue Development of Lipid Nano-Pharmaceutical Formulations for Oral/Dermal/Transdermal Delivery)

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Open AccessArticle

Formulation of Miconazole-Loaded Chitosan–Carbopol Vesicular Gel: Optimization to In Vitro Characterization, Irritation, and Antifungal Assessment

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Pharmaceutics 2023, 15(2), 581; https://doi.org/10.3390/pharmaceutics15020581 - 08 Feb 2023

Cited by 6 | Viewed by 1324

Abstract

Miconazole nitrate (MN) is a poorly water-soluble and antifungal drug used for fungal infections. The present research work was designed to develop topical MN-loaded bilosomes (BSs) for the improvement of therapeutic efficacy. MZBSs were prepared by using the thin-film hydration method and further optimized by using the Box–Behnken statistical design (BBD). The optimized miconazole bilosome (MZBSo) showed nano-sized vesicles, a low polydispersity index, a high entrapment efficiency, and zeta potential. Further, MZBSo was incorporated into the gel using carbopol 934P and chitosan polymers. The selected miconazole bilosome gel (MZBSoG2) demonstrated an acceptable pH (6.4 ± 0.1), viscosity (1856 ± 21 cP), and spreadability (6.6 ± 0.2 cm²). Compared to MZBSo (86.76 ± 3.7%), MZBSoG2 showed a significantly (p < 0.05) slower drug release (58.54 ± 4.1%). MZBSoG2 was found to be a non-irritant because it achieved a score of zero (standard score) in the HET-CAM test. It also exhibited significant antifungal activity compared to pure MZ against Candida albicans and Aspergillus niger. The stability study results showed no significant changes after stability testing under accelerated conditions. MZ-loaded gels could serve as effective alternative carriers for improving therapeutic efficacy. Full article

(This article belongs to the Special Issue Development of Lipid Nano-Pharmaceutical Formulations for Oral/Dermal/Transdermal Delivery)

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Review

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Open AccessReview

Microneedles and Their Application in Transdermal Delivery of Antihypertensive Drugs—A Review

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Pharmaceutics 2023, 15(8), 2029; https://doi.org/10.3390/pharmaceutics15082029 - 27 Jul 2023

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Abstract

One of the most cutting-edge, effective, and least invasive pharmaceutical innovations is the utilization of microneedles (MNs) for drug delivery, patient monitoring, diagnostics, medicine or vaccine delivery, and other medical procedures (e.g., intradermal vaccination, allergy testing, dermatology, and blood sampling). The MN-based system offers many advantages, such as minimal cost, high medical effectiveness, comparatively good safety, and painless drug application. Drug delivery through MNs can possibly be viewed as a viable instrument for various macromolecules (e.g., proteins, peptides, and nucleic acids) that are not efficiently administered through traditional approaches. This review article provides an overview of MN-based research in the transdermal delivery of hypertensive drugs. The critical attributes of microneedles are discussed, including the mechanism of drug release, pharmacokinetics, fabrication techniques, therapeutic applications, and upcoming challenges. Furthermore, the therapeutic perspective and improved bioavailability of hypertensive drugs that are poorly aqueous-soluble are also discussed. This focused review provides an overview of reported studies and the recent progress of MN-based delivery of hypertensive drugs, paving the way for future pharmaceutical uses. As MN-based drug administration bypasses first-pass metabolism and the high variability in drug plasma levels, it has grown significantly more important for systemic therapy. In conclusion, MN-based drug delivery of hypertensive drugs for increasing bioavailability and patient compliance could support a new trend of hypertensive drug delivery and provide an alternative option, overcoming the restrictions of the current dosage forms. Full article

(This article belongs to the Special Issue Development of Lipid Nano-Pharmaceutical Formulations for Oral/Dermal/Transdermal Delivery)

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