Special Issues

Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Perspectives in Ocular Pharmacology: 2nd Edition submission deadline 26 Apr 2026 | Viewed by 11 | Submission Open
Keywords: ocular pharmacology; pharmacodynamics; ophthalmology; drug delivery systems
(This special issue belongs to the Section Pharmacology)
Natural Products and Their Modifications as Agents Used in the Fight Against Pathogens, 2nd Edition
edited by
submission deadline 27 Apr 2026 | 1 articles | Viewed by 1187 | Submission Open
Keywords: plant extract; natural compounds; multidrug-resistant strains; intestinal microbiota; chemical modyfication; biotransformation
(This special issue belongs to the Section Natural Products)
Fluoroquinolones, 2nd Edition
edited by and
submission deadline 27 Apr 2026 | Viewed by 62 | Submission Open
Keywords: fluoroquinolones; fluoroquinolone-associated disability; antibiotic safety; fluoroquinolone toxicity; antibiotic stewardship
(This special issue belongs to the Section Pharmacology)
Tumor Immunopharmacology, 2nd Edition submission deadline 27 Apr 2026 | Viewed by 35 | Submission Open
Keywords: immunotherapy; immunomodulation; drug development; cytokine receptor antagonist; T-cell based therapies; therapeutic antibodies; drug delivery; cancer vaccine; immunoresistance; tumor-infiltrating lymphocytes (TILs); immune escape; immune checkpoint inhibitors; cytokine-based therapies; small molecule immunomodulators; combination therapy; precision oncology; tumor mutational burden (TMB); antibody-dependent cellular cytotoxicity (ADCC ); complement-dependent cytotoxicity (CDC); myeloid-derived suppressor cells (MDSCs)
(This special issue belongs to the Section Pharmacology)
Pharmacological Activity and Application of Polyphenolic Compounds
edited by
submission deadline 30 Apr 2026 | Viewed by 1060 | Submission Open
Keywords: phenolic compounds; biological potential; pharmacological activity; phenolic applications; health promoters; chronic diseases
(This special issue belongs to the Section Natural Products)
Therapeutic Potential of Natural Plant-Derived Compounds in Glioblastoma and Other Brain Tumors submission deadline 30 Apr 2026 | Viewed by 132 | Submission Open
Keywords: glioblastoma; GBM; brain tumors; natural plant‑derived compounds; phytochemicals; blood– brain barrier; signaling targets; tumor microenvironment; therapeutic opportunities; targeted therapy
(This special issue belongs to the Section Natural Products)
Neuropharmacology of Plant Extracts and Their Active Compounds (Second Edition) submission deadline 30 Apr 2026 | Viewed by 111 | Submission Open
Keywords: medicinal plant; mental disorder; preclinical; clinical
(This special issue belongs to the Section Natural Products)
Innovative Drug Delivery and Mitochondrial-Targeted Therapies
edited by José Antonio Jara Sandoval and Alfredo E. Molina-Berríos
submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open
Keywords: drug delivery; mitochondrial-targeted therapies; mitochondrial dysfunction; novel formulations; therapeutic strategies; mitocans; targeting mitochondria
(This special issue belongs to the Section Pharmacology)
New Trends in the Treatment of Neuropsychiatric Disorders submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open
Keywords: treatment; depression; schizophrenia; bipolar disorder; Alzheimer’ s disease
(This special issue belongs to the Section Pharmacology)
Innovative Organic Synthesis Approaches in Drug Design and Development submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open
Keywords: sustainable organic synthesis; green chemistry; drug design and development; non-traditional solvents; Lewis acid catalysis; catalytic methodologies; photoredox and electrochemical methods; medicinal chemistry innovation
(This special issue belongs to the Section Medicinal Chemistry)
The Therapeutic Potential of Neurotrophin Signaling in Neurodegenerative Disorders
edited by Konstantina Chanoumidou, and
submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open
Keywords: central nervous system; neurodegeneration; neuroinflammation; therapy; neurotrophin receptors; regeneration; myelination
(This special issue belongs to the Section Pharmacology)
Computational Predictions of Molecules with Potential Therapeutic Effects: 2nd Edition
edited by
submission deadline 30 Apr 2026 | Viewed by 25 | Submission Open
Keywords: biophysics; medicinal chemistry; drug discovery; molecular docking; molecular dynamics; structure-activity relationships; computer-aided drug design (CADD)
(This special issue belongs to the Section Pharmacology)
Ophthalmic Drugs and Pharmacology
edited by Christin Henein and Sahar Awwad
submission deadline 1 May 2026 | Viewed by 87 | Submission Open
Keywords: ophthalmic diseases; optic neuropathies; eye diseases; glaucoma; corneal disorders; retinal degeneration; ocular surface disease
(This special issue belongs to the Section Pharmacology)
Innovative Computational and Experimental Strategies in Antimicrobial Drug Discovery submission deadline 10 May 2026 | Viewed by 32 | Submission Open
Keywords: antimicrobial resistance; multidrug resistance; small molecules; novel antimicrobial entities; in silico drug discovery; in vitro screening; innovative strategies; drug repurposing; structure– activity relationship; rational drug design
(This special issue belongs to the Section Medicinal Chemistry)
Allosteric Drug Design in the AI Era
edited by Lydia Siragusa and
submission deadline 15 May 2026 | Viewed by 63 | Submission Open
Keywords: allosteric modulation; artificial intelligence in drug discovery; computational pharmacology; allosteric sites prediction; structure-based drug design
(This special issue belongs to the Section AI in Drug Development)
Metals in Cancer Research: Beyond Platinum Metallodrugs
edited by and
submission deadline 15 May 2026 | Viewed by 5 | Submission Open
Keywords: anticancer drugs; metal complexes; non-platinum; drug resistance; targeted therapy
(This special issue belongs to the Section Medicinal Chemistry)
Novel Drug Compositions for Ischemic Stroke: Mechanisms and Clinical Applications submission deadline 20 May 2026 | 1 articles | Viewed by 1835 | Submission Open
Keywords: ischemic stroke; novel delivery systems; nanomedicine; nanotechnology; neuroregenerative therapy; neurorepair; new and emerging treatments; pharmacotherapy; tissue engineering
(This special issue belongs to the Section Pharmacology)
Solid State Chemistry and Materials Science in Pharmaceutical Research: From Solid Forms to Advanced Dosage Forms
edited by Norbert Nagel, Wenqian Chen and Raimundo Ho
submission deadline 20 May 2026 | Viewed by 122 | Submission Open
Keywords: solid forms; solid form screening; pharmaceutical salts; polymorphism; hydrates; co-crystals; materials science; manufacturing process understanding; solid dosage forms; semi-solid dosage forms; pharmaceutical amorphous solid dispersions; enabling formulations; crystal structure prediction; material science tetrahedron; computational chemistry; structure-property relationships
(This special issue belongs to the Section Pharmaceutical Technology)
Therapeutic Methods Against Acute and Chronic Diseases and Oxidative Stress
edited by
submission deadline 25 May 2026 | 3 articles | Viewed by 7271 | Submission Open
Keywords: natural antioxidant; synthetic agents; acute diseases; chronic diseases; oxidative stress
(This special issue belongs to the Section Medicinal Chemistry)
The Therapeutic Potential of Cannabidiol submission deadline 25 May 2026 | 1 articles | Viewed by 3208 | Submission Open
Keywords: cannabidiol; endocannabinoid system; pain; anti-inflammatory agents; muscle spasticity; pain management; chronic pain
(This special issue belongs to the Section Natural Products)
Sirtuins as Novel Biological Targets for Pharmacological Intervention in Physiology and Pathology—2nd Edition submission deadline 25 May 2026 | 2 articles | Viewed by 2017 | Submission Open
Keywords: sirtuins; metabolism; cancer; hypoxia; damage recovery; cell death
(This special issue belongs to the Section Pharmacology)
Antidiabetic Agents: New Drug Discovery Insights and Prospects
edited by Rosanna Maccari
submission deadline 25 May 2026 | Viewed by 137 | Submission Open
Keywords: diabetes mellitus; drug design; drug discovery; drug development; drug synthesis; computational-aided drug design; molecular targets; biological activity; structure– activity relationships
(This special issue belongs to the Section Medicinal Chemistry)
Research Advances in Targeted Therapy for Facial Skin Diseases
edited by , and Diogo Pazzini Bomfim
submission deadline 25 May 2026 | Viewed by 69 | Submission Open
Keywords: facial dermatoses; targeted therapy; biologics; precision dermatology; acne vulgaris; topical drug delivery
(This special issue belongs to the Section Pharmacology)
Natural Products in Diabetes Mellitus: 3rd Edition submission deadline 25 May 2026 | Viewed by 54 | Submission Open
Keywords: natural products; hypoglycemia; phenolic compounds; diabetes mellitus; therapeutic; ROS
(This special issue belongs to the Section Natural Products)
Impact of Drug Transporter Gene Variation on Pharmacokinetics and Clinical Outcomes in Chronic Disease Therapy submission deadline 25 May 2026 | Viewed by 51 | Submission Open
Keywords: drug transporter gene variants; chronic diseases; pharmacokinetics; clinical therapeutic effects; individualized medication; ABCB1; SLC22A family; SLCO1B1
(This special issue belongs to the Section Pharmacology)
Natural Bioactive Substances: Microencapsulation Technologies, Pharmacological Efficacies and Sustainable Application in Pharmaceuticals submission deadline 25 May 2026 | Viewed by 47 | Submission Open
Keywords: natural bioactive substances; microencapsulation technologies; pharmacological efficacy; sustainable pharmaceutical application; drug carrier materials; bioavailability; controlled release; green pharmacy
(This special issue belongs to the Section Pharmaceutical Technology)
Deregulated Signaling Pathways and Innovative Therapeutic Approaches in Cancer
edited by and Ioannis S. Pappas
submission deadline 25 May 2026 | Viewed by 47 | Submission Open
Keywords: anti-cancer therapeutic approaches; innovative therapeutics; molecular biology; deregulated signaling pathways; oncogenes; tumor repressor partners; antioxidant mechanisms; mAbs; targeted therapies
(This special issue belongs to the Section Pharmacology)
Hepatitis B and Delta Virus Infections: Mechanistic Insights and Clinical Drug Therapy
edited by Daniele Lombardo
submission deadline 25 May 2026 | Viewed by 43 | Submission Open
Keywords: chronic hepatitis B; hepatitis delta virus coinfection; hepatocellular carcinoma risk; antiviral drug development; HBV functional cure strategies; immune modulation in hepatitis; pharmacological therapies for viral hepatitis
(This special issue belongs to the Section Pharmacology)
Histamine Receptors: Ligand Design, Pharmacology, and Therapeutic Applications submission deadline 25 May 2026 | Viewed by 27 | Submission Open
Keywords: histamine receptors; drug discovery; ligand design; antagonist/inverse agonist; pharmacology; therapeutic applications; multi-target directed ligands; molecular modeling
(This special issue belongs to the Section Pharmacology)
Development of Specific Dosage Form: Wound Dressing, 2nd Edition
edited by , , and Cristina Elena Dinu-Pirvu
submission deadline 25 May 2026 | Viewed by 21 | Submission Open
Keywords: skin lesion; wound healing; wound dressing; regenerative medicine; biomaterials; smart biopolymers; therapeutic system; controlled delivery system; scaffolds; biocompatibility
(This special issue belongs to the Section Pharmaceutical Technology)
Peptide-Based Therapeutics: Targeting Amylin, Calcitonin, and Related Receptors submission deadline 25 May 2026 | Viewed by 20 | Submission Open
Keywords: GPCR; amylin; obesity; diabetes; peptide-based drugs; long-acting agonists
(This special issue belongs to the Section Biopharmaceuticals)
Natural Products for Treating Hypertension and Blood Sugar submission deadline 25 May 2026 | Viewed by 1 | Submission Open
Keywords: antihypertensive; diabetes; cardioprotective; herbal medicine; hypertension; medicinal plants; natural products
(This special issue belongs to the Section Natural Products)
Computational Methods in Drug Development
edited by
submission deadline 26 May 2026 | 9 articles | Viewed by 20443 | Submission Open
Keywords: computational modeling; DNA/RNA and protein; drug discovery and design; systems biology; channels and membranes; biomedical data analysis; artificial intelligence; molecule docking and scoring
(This special issue belongs to the Section Medicinal Chemistry)
Sex Differences in Pharmaceutical Practice: 2nd Edition submission deadline 28 May 2026 | Viewed by 30 | Submission Open
Keywords: sex; differences; drugs; kinetics; dynamics; preclinical; clinical; research
(This special issue belongs to the Section Medicinal Chemistry)
Precision Oncology: Targeting Molecular Subtypes in Cancer Therapy
edited by and Jiro Ogura
submission deadline 29 May 2026 | 3 articles | Viewed by 2562 | Submission Open
Keywords: cancer chemotherapy; cancer genomic profiling test; next-generation sequencing; genetic variants; molecular targeted therapy; molecular tumor board; liquid biopsy
(This special issue belongs to the Section Pharmacology)
Exploring Novel Therapies and Drug Efficacy for Inflammatory Bowel Disease submission deadline 30 May 2026 | Viewed by 83 | Submission Open
Keywords: Crohn's disease; ulcerative colitis; pharmacology; antioxidants; novel therapies; gut microbiome; inflammation
(This special issue belongs to the Section Pharmacology)
Small-Molecule Inhibitors for Novel Therapeutics
edited by and Simone Giovannuzzi
submission deadline 31 May 2026 | 4 articles | Viewed by 17638 | Submission Open
Keywords: small molecules; enzyme inhibition/activation; protein modulation; novel therapeutics; high-throughput screening; target proteins; drug delivery
Novel Anticancer Drug Development and Toxicity Reduction Strategies
edited by
submission deadline 31 May 2026 | 3 articles | Viewed by 3015 | Submission Open
Keywords: cancer; targeted therapy; anticancer drug; structure-based computational technique; combination therapy; nanocarriers; hydrogels
(This special issue belongs to the Section Medicinal Chemistry)
Polymers, Nanoparticles and Hydrogels for Drug Delivery: Strategies and Applications
edited by Mónica de la Luz Corea Téllez, Marlon Rojas López, and Rogelio Jiménez-Juárez
submission deadline 31 May 2026 | Viewed by 177 | Submission Open
Keywords: drug delivery; medical applications; hydrogels; polymers; nanoparticles; drug delivery system; multi-stimuli-responsive materials; nanocomposites; biofilms; biomarkers
(This special issue belongs to the Section Pharmaceutical Technology)
Applications of Stem Cells and Organoids in Disease Modeling, Drug Discovery and Clinical Evaluation
edited by Daniela Omodei
submission deadline 31 May 2026 | Viewed by 103 | Submission Open
Keywords: stem cells; patient-derived cells; iPSCs (induced pluripotent stem cells); organoids; drug development; drug screening; drug toxicity; preclinical and clinical drug research; novel therapeutics; disease modeling; personalized medicine; precision medicine
(This special issue belongs to the Section Pharmacology)
Advances in Theranostic Radiopharmaceuticals
edited by
submission deadline 31 May 2026 | Viewed by 71 | Submission Open
Keywords: theranostics; radiopharmacy; targeted alpha therapy; preclinical imaging; radiobiology; radioisotope production; molecular radiotherapy; positron emission tomography; single photon emission tomography
(This special issue belongs to the Section Radiopharmaceutical Sciences)
Drug Candidates for the Treatment of Obesity, 3rd Edition submission deadline 31 May 2026 | Viewed by 43 | Submission Open
Keywords: obesity  ; appetite supressors  ; nutraceuticals  ; plant extracts  ; lipid metabolism  ; high-fat diet  ; adipogenesis
(This special issue belongs to the Section Medicinal Chemistry)
Pharmacological Treatments for Parasitic Diseases
edited by Maria Dichiara and
submission deadline 31 May 2026 | Viewed by 23 | Submission Open
Keywords: parasitic diseases; antiparasitic agents; drug resistance; therapeutic strategies; drug discovery; neglected tropical diseases (NTDs); medicinal chemistry; global health
(This special issue belongs to the Section Medicinal Chemistry)
Targeting the NLRP3: From Novel Inhibitor Design to Clinic Trials and Therapeutic Applications
edited by and
submission deadline 31 May 2026 | Viewed by 8 | Submission Open
Keywords: NLRP3 inflammasome; selective and direct NLRP3 inhibitors; drug discovery; clinical trial; therapeutic applications
(This special issue belongs to the Section Biopharmaceuticals)
Anti-Fbibrosis Agent Development
edited by Younghwa Na
submission deadline 31 May 2026 | Submission Open
Keywords: idiopathic pulmonary fibrosis (IPF); anti-fibrosis; drug discovery; combination therapies; personalized medicine
(This special issue belongs to the Section Medicinal Chemistry)
Epigenetic Regulatory Mechanisms and Applications of Non-Coding RNAs in Chemoresistance and Metabolic Disorders
edited by , Francisca Villagrán-Silva and Pablo J. Letelier
submission deadline 15 Jun 2026 | Viewed by 91 | Submission Open
Keywords: non-coding RNAs; epigenetic regulation; chemoresistance; metabolic disorders; chemotherapy-related toxicities; DNA methylation; histone modification; chromatin remodeling; RNA-based therapeutics; biomarkers
(This special issue belongs to the Section Biopharmaceuticals)
Allosteric Modulators: Unlocking New Dimensions from Molecular Discovery to Therapeutic Potential
edited by , and Kwangho Kim
submission deadline 20 Jun 2026 | Viewed by 12 | Submission Open
Keywords: allosteric binding sites; protein– ligand interactions; mechanism of action; isoform selectivity; signal bias; structure-based design; pharmacological profiling; allosteric anchoring; GPCRs; ion channels; kinases; heterobifunctional ligand; allosteric synergy
(This special issue belongs to the Section Medicinal Chemistry)
Tumor Therapy and Drug Delivery: 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 11 | Submission Open
Keywords: antitumor therapy; drug-delivery systems; nanocarriers; immunoconjugates; nanotechnology; cancer selectivity
(This special issue belongs to the Section Pharmaceutical Technology)
Pharmaceutical Applications of Cannabinoids submission deadline 25 Jun 2026 | 1 articles | Viewed by 1026 | Submission Open
Keywords: cannabis; cannabinoids; therapeutic properties; medicinal plant; phytochemicals
Therapeutic Potential of Cannabinoid Receptors Type 1 and 2—Novel Insights for Enhancing the Chance of Clinical Success, 2nd Edition
edited by
submission deadline 30 Jun 2026 | 2 articles | Viewed by 1715 | Submission Open
Keywords: endocannabinoid system (ECS); cannabinoid receptor type 1 (CB1R); cannabinoid receptor type 2 (CB2R); cannabinoids; ligand
(This special issue belongs to the Section Pharmacology)
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