Special Issue "Plant-Pathogen Interactions"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 3622

Special Issue Editor

Dr. Hernan Garcia-Ruiz
E-Mail Website
Guest Editor
Department of Plant Pathology, Nebraska Center for Virology, University of Nebraska-Lincoln, Lincoln, NE 68583, USA
Interests: plant-virus interactions; antiviral RNA silencing; viral RNA replication; virus genomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plants interact with a diverse array of organisms, including insects, nematodes, microbes, and other plants. Plant–microbe interactions could result in disease or beneficial relationships. For any plant–microbe combination, the interaction could be incompatible or compatible. Plant pathogens, including bacteria, fungi, oomycetes, viruses, and nematodes, must evade or actively suppress plant defense responses. Understanding the molecular mechanisms of plant defense and microbe pathogenicity represents the basis for disease management, genetic engineering of disease resistance through gene editing, RNA silencing u other approaches. This Special Issue on plant–pathogen interactions is focused on recent advances in understanding the molecular and genetic basis of plant defense, pathogenicity or the establishment of beneficial relationships. Variation in plant or pathogen factors, computational modeling or methodologies that advance our understanding of plant–pathogen interactions are of interest. You are invited to submit primary research articles or reviews presenting recent advances.

Dr. Hernan Garcia-Ruiz
Guest Editor

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  • Pathogenicity
  • Virulence
  • Effectors
  • Susceptibility genes
  • Resistance genes
  • Gene networks
  • Molecular determinants

Published Papers (1 paper)

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The 3′ Untranslated Region of a Plant Viral RNA Directs Efficient Cap-Independent Translation in Plant and Mammalian Systems
Pathogens 2019, 8(1), 28; https://doi.org/10.3390/pathogens8010028 - 28 Feb 2019
Cited by 7 | Viewed by 2987
Many plant viral RNA genomes lack a 5′ cap, and instead are translated via a cap-independent translation element (CITE) in the 3′ untranslated region (UTR). The panicum mosaic virus-like CITE (PTE), found in many plant viral RNAs, binds and requires the cap-binding translation [...] Read more.
Many plant viral RNA genomes lack a 5′ cap, and instead are translated via a cap-independent translation element (CITE) in the 3′ untranslated region (UTR). The panicum mosaic virus-like CITE (PTE), found in many plant viral RNAs, binds and requires the cap-binding translation initiation factor eIF4E to facilitate translation. eIF4E is structurally conserved between plants and animals, so we tested cap-independent translation efficiency of PTEs of nine plant viruses in plant and mammalian systems. The PTE from thin paspalum asymptomatic virus (TPAV) facilitated efficient cap-independent translation in wheat germ extract, rabbit reticulocyte lysate, HeLa cell lysate, and in oat and mammalian (BHK) cells. Human eIF4E bound the TPAV PTE but not a PTE that did not stimulate cap-independent translation in mammalian extracts or cells. Selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE) footprinting revealed that both human and wheat eIF4E protected the conserved guanosine (G)-rich domain in the TPAV PTE pseudoknot. The central G plays a key role, as it was found to be required for translation and protection from SHAPE modification by eIF4E. These results provide insight on how plant viruses gain access to the host’s translational machinery, an essential step in infection, and raise the possibility that similar PTE-like mechanisms may exist in mRNAs of mammals or their viruses. Full article
(This article belongs to the Special Issue Plant-Pathogen Interactions)
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