Special Issue "Environmental Reservoirs of Microbial Pathogens to Humans"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: closed (30 June 2020).

Special Issue Editor

Dr. Johannes Werner
E-Mail Website
Guest Editor
Department of Biological OceanographyLeibniz Institute of Baltic Sea ResearchSeestraße 15D-18119 Rostock-WarnemündeGermany
Interests: environmental microbiology; marine microbiology; bioinformatics; (meta)genomics/transcriptomics/proteomics; comparative genomics; extremophiles; systems biology

Special Issue Information

Dear colleagues,

Many pathogens are recognized by their infectious stage in humans, although some of these pathogens are able to survive or even persist in other hosts or environments. Indeed, human pathogens can originate from a range of environmental reservoirs; for instance, Vibrio cholera may persist and be transmitted via water sources, and Bacillus anthracis can persist as spores in soil. While outside a living host, pathogens require specific mechanisms to survive, grow, or even proliferate in their new habitat. Understanding the ecology of pathogens outside the human host may help us to elucidate the origin of pathogenesis mechanisms, such as if the pathogen had evolved to invade tissues of other organisms in its habitat or to produce biofilms or spores to survive harsh conditions. Inquiry into these and other pathogenesis strategies can help us to understand molecular host–microbe interactions and niche specialization, and may become part of a systems biology strategy to epidemiology.

For this Special Issue, we invite you to submit papers and reviews on environmental reservoirs of microbial pathogens to humans. Potential topics include, but are not limited to:

  • population studies of pathogens in the environment;
  • taxonomy of pathogens and closely related species;
  • comparative genomics;
  • description of new isolates;
  • physiology;
  • mechanisms of host–microbe interaction;
  • mechanisms of persistence in the environment;
  • pathogenesis;
  • human health implications;
  • viral reservoirs and diversity.

Dr. Johannes Werner
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessArticle
Simultaneous Nasal Carriage by Methicillin-Resistant and Methicillin Susceptible Staphylococcus aureus of Lineage ST398 in a Live Pig Transporter
Pathogens 2020, 9(5), 401; https://doi.org/10.3390/pathogens9050401 - 21 May 2020
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Methicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST)398 is a livestock associated (LA) lineage with zoonotic potential, especially in humans with live pig contact. The objective of this study was to characterize two S. aureus strains of lineage ST398 (one methicillin-resistant (MRSA), one methicillin-susceptible [...] Read more.
Methicillin-resistant Staphylococcus aureus (MRSA) sequence type (ST)398 is a livestock associated (LA) lineage with zoonotic potential, especially in humans with live pig contact. The objective of this study was to characterize two S. aureus strains of lineage ST398 (one methicillin-resistant (MRSA), one methicillin-susceptible (MSSA)) isolated from the same nasal sample of a patient admitted in the Intensive-Care Unit of a Spanish Hospital, and with previous occupational exposure to live pigs, by whole-genome-sequencing (WGS). The sample was obtained during routine surveillance for MRSA colonization. Purified genomic DNA was sequenced using Illumina HiSeq 2000 and processed using conventional bioinformatics software. The two isolates recovered were both S. aureus t011/ST398 and showed similar resistance-phenotypes, other than methicillin susceptibility. The possession of antibiotic resistance genes was the same, except for the mecA-gene located in SCCmecV in the MRSA isolate. The MSSA isolate harbored remnants of a SCCmec following the deletion of 17342bp from a recombination between two putative primases. Both isolates belonged to the livestock-associated clade as defined by three canonical single-nucleotide-polymorphisms, and neither possessed the human immune evasion cluster genes, chp, scn, or sak. The core genome alignment showed a similarity of 99.6%, and both isolates harbored the same mobile genetic elements. The two nasal ST398 isolates recovered from the patient with previous occupational exposure to pigs appeared to have a livestock origin and could represent different evolutionary steps of animal-human interface lineage. The MSSA strain was formed as a result of the loss of the mecA gene from the livestock-associated-MRSA lineage. Full article
(This article belongs to the Special Issue Environmental Reservoirs of Microbial Pathogens to Humans)
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