Special Issue "Translational Control at the Virus–Host Interface"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: 15 August 2020.
Interests: viruses; translational control; RNA biology; stress responses; membraneless organelles
The synthesis of viral proteins, whose functions include genome replication, evasion of immune defenses, and virion biogenesis, is wholly dependent on host cell translation machinery. However, during infection, the accumulation of RNA replication intermediates or viral proteins imposes major stress on the host cell. In response to this stress, infected cells can induce several defense mechanisms to promote cell survival and limit the use of energy and nutrients, which can culminate in a global reduction of protein synthesis. These mechanisms can target the subcellular localization of mRNAs, the activity of cellular translation factors, or the induction of specific translational reprogramming. Yet, to ensure that viral protein synthesis continues despite the host response or viral modulation of the translation machinery, viruses have evolved diverse strategies to outcompete cellular mRNAs and harness host translation capacity by evolving alternative translation mechanisms.
With recent examples of modulation of key cellular signaling nodes controlling translational activity during infection, novel understanding of viral hijacking of the ribosomal machinery at the structural and biochemical levels, expanding coding capacity by viruses, and increased appreciation of how the cellular landscape of translation is remodeled during infection, Pathogens is launching a Special Issue focused on “Translational Control at the Virus–Host Interface”.
Prof. Nicolas Locker
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
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