Special Issue "Pathogenic Polymicrobial Infections, Biofilms, and Adaptive Drug Resistance"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (28 February 2021).
Interests: Infectious diseases; Antimicrobial resistance; Stress response; Animal models; ESKAPE pathogens; Skin infections; Polymicrobial infections; Host-pathogen interaction; Infection models
Traditionally, infectious diseases have been attributed to individual pathogens but recent progress in microbial whole-genome sequencing revealed the presence of polymicrobial communities. For example, most chronic wound infections are polymicrobial in nature (i.e., two or more species of microbes occupy the same infection site and interact in a cooperative or competitive manner). The colonization of multispecies communities with pathogenic bacteria can not only implicate disease progression but also complicate antimicrobial treatment and effectiveness.
Microorganisms that live in biofilms have the ability to cope with the host immune system and overcome antibiotic treatment due to adaptive behavior that can make them up to 1000-fold more resistant to antibiotics. Biofilm infections cause two-thirds of all clinical infections and have been thought to play a major role in reducing therapeutic effectiveness of antimicrobial compounds. As we know now, this is further impacted by the presence of polymicrobial biofilm communities. However, how pathogenic communities influence antimicrobial (adaptive) resistance and therapeutic outcomes is still poorly understood.
This Special Issue will focus on pathogenic polymicrobial infections, antimicrobial (adaptive) resistance within communities, and will discuss potential treatment strategies. We would like to invite the submission of original research, review articles, or short communications that report on recent progress to further expand our knowledge of complex diseases.
Dr. Daniel Pletzer
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Polymicrobial infections
- Antimicrobial resistance
- Pathogenic microorganisms
- Polymicrobial biofilms
- Adaptive resistance