Special Issue "Oral Bacteria"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: closed (28 February 2019) | Viewed by 2364

Special Issue Editor

Dr. Aruni Wilson
Guest Editor
Division of MicrobiologySchool of MedicineLoma Linda UniversityLoma Linda, CA 92350U.S.A
Interests: Human oral microbiome and systemic diseases; Human oral virome; Host pathogen interaction;

Special Issue Information

Dear Colleagues,

Oral bacteria account for the majority of the oral microbiome, and has been studied extensively in health and disease. Among the 700 species of oral bacteria, earlier studies only focused on a specific group of bacteria that cause major oral diseases, such as periodontitis. However, there is now a paradigm shift in research, focusing on many un-cultivable oral bacteria and their community dynamics in causing diseases. Studies in the past few years have shown the causal relationship of many oral bacteria in important systemic diseases. Because of their strong community synergism, biofilm-forming oral bacteria have been extensively studied and have recently been brought to light new findings on pathogen and bacterial profiles in health and disease states. With the key stone pathogen concept in causing dysbiotic communities. The mechanisms used by oral bacteria to cause such dysbiosis are unclear, but their virulence factors are known to effectively subvert host defenses to their advantage, allowing other pathogens to grow. Microbial pathogens have evolved multiple strategies for interacting with host cell components and plays a significant role in causing dysbiosis. Hence, oral bacterial profiling and studies on population changes have been seriously looked into diagnosis and treatment. For this Special Issue on “Oral Bacteria”, we invite you to submit articles related to the oral microbiome, host–pathogen interactions, the causal relationship of oral bacteria in systemic diseases, and oral bacterial virulence and pathogenesis. We look forward to your contributions.

Dr. Aruni Wilson
Guest Editor

Manuscript Submission Information

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  • oral bacteria
  • yet-un cultivable bacteria
  • oral dysbiotic microflora
  • oral microbiome
  • Host -pathogen interaction

Published Papers (1 paper)

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Bacterial sialoglycosidases in Virulence and Pathogenesis
Pathogens 2019, 8(1), 39; https://doi.org/10.3390/pathogens8010039 - 24 Mar 2019
Cited by 8 | Viewed by 2135
Human oral microbiome and dysbiotic infections have been recently evidently identified. One of the major reasons for such dysbiosis is impairment of the immune system. Periodontitis is a chronic inflammatory disease affecting the tissues that surround and support the teeth. In the United [...] Read more.
Human oral microbiome and dysbiotic infections have been recently evidently identified. One of the major reasons for such dysbiosis is impairment of the immune system. Periodontitis is a chronic inflammatory disease affecting the tissues that surround and support the teeth. In the United States., approximately 65 million people are affected by this condition. Its occurrence is also associated with many important systemic diseases such as cardiovascular disease, rheumatoid arthritis, and Alzheimer’s disease. Among the most important etiologies of periodontitis is Porphyromonas gingivalis, a keystone bacterial pathogen. Keystone pathogens can orchestrate inflammatory disease by remodeling a normally benign microbiota causing imbalance between normal and pathogenic microbiota (dysbiosis). The important characteristics of P. gingivalis causing dysbiosis are its virulence factors which cause effective subversion of host defenses to its advantage allowing other pathogens to grow. Some of the mechanisms involved in these processes are still not well-understood. However, various microbial strategies target host sialoglycoproteins for immune dysregulation. In addition, the enzymes that break down sialoglycoproteins and sialoglycans are the “sialoglycoproteases”, resulting in exposed terminal sialic acid. This process could lead to pathogen-toll like receptor (TLR) interactions mediated through sialic acid receptor ligand mechanisms. Assessing the function of P. gingivalis sialoglycoproteases, could pave the way to designing carbohydrate analogues and sialic acid mimetics to serve as drug targets. Full article
(This article belongs to the Special Issue Oral Bacteria)
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