Special Issue "KSHV-Host Stand-Off (or Interaction)"
Deadline for manuscript submissions: closed (1 March 2021).
Virus-associated cancers comprise approximately 15%–20% of all human tumors worldwide. It is the second most important risk factor for the development of cancer in humans, exceeded only by tobacco consumption. Herpesvirus represents the most ubiquitous pathogen in humans, and their infections are implicated in diverse malignancies. Human Kaposi’s-sarcoma-associated herpesvirus (KSHV) and Epstein–Barr virus (EBV) belong to gamma-2 herpesvirinae and are associated with tumors of lymphoid, epithelial, and endothelial origin in immune-compromised patients such as HIV/AIDS patients and organ transplant patients. Approximately 600,000 new cases of KSHV- and EBV-associated cancers are annually reported worldwide. Despite being a pressing human health problem, very little has been done thus far to develop therapeutic agents that specifically target these virus-associated diseases. Furthermore, the mechanisms that govern gamma-2 herpesvirus immunity and pathogenesis are poorly understood.
For this Special Issue of Pathogens, we aim to understand the molecular mechanisms deployed by gamma-2 herpesvirus to evade and survive the host’s immune responses as well as viral host interactions at the cellular level to reshape the cellular environment for their life cycle. Thereby, we welcome to invite you to submit either an original research article or an insightful review.
Prof. Hye-ra Lee
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Kaposi’s-sarcoma-associated herpesvirus (KSHV)
- Epstein–Barr virus (EBV)
- gamma-2-herpesviruses-associated malignancies
- evasion of immune responses
- virus–host interaction
- viral gene expression and replication