Special Issue "Herpesvirus Entry"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: closed (28 February 2019).

Special Issue Editor

Assoc. Prof. Vaibhav Tiwari
Guest Editor
Department of Microbiology & Immunology Science, Midwestern University
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Herpes simplex virus (HSV) is a prevalent pathogen with various clinical manifestations, ranging from common cold sore, gingivostomatitis, herpetic whitlow, corneal herpetic stromal keratitis, genital ulcers, and sometimes more serious complications, such as encephalitis and meningitis. The current model of HSV entry suggests that the virus uses multiple pathways during entry, depending on cell types and entry receptors. HSV-1 entry generally begins with viral attachment to host cells in which HSV glycoproteins B (gB) and C (gC) on the envelope of the virus typically bind to heparan sulfate (HS) on the surface of the host cell. This is followed by gD binding to one of its cognate receptors, including an intercellular adhesion molecule: nectin−1 or −2 and a member of the tumor necrosis factor receptor family: Herpesvirus entry mediator (HVEM). The virus also uses a modified version of HS known as 3-O sulfated heparan sulfate (3-OS HS) to bind gD and induce virus cell fusion, independent of the known protein receptors. Viral interactions with these receptors initiate fusion between the viral envelope and the membrane of the cell, which also requires participation of two additional HSV glycoproteins gH and gL. Upon fusion, the nucleocapsid and tegument are released into the cytoplasm where they are transported to the nucleus via microtubules.  Previous studies have shown that HSV entry exploits host cell cytoskeleton via a novel phagocytic uptake in human corneal fibroblasts cells and that modified 3-OS HS plays a significant role in promoting viral entry and spread via F-actin membrane extensions, such as filopodia. Recent studies also highlight the herpes virus usage of tunneling nanotubes to promote cell-to-cell spread.  In this special issue on “herpesvirus entry into host cell” will focus on the current status of our understanding on herpes virus (Herpes simplex virus, Varicella zoster virus, Cytomegalovirus, Human herpes virus-6, 7, Epstein Barr virus and Kaposi Sarcoma virus) entry and spread to have an opportunity for future therapeutic intervention. We thus invite submission of research and review articles that cover broader aspects in herpesvirus entry, spread and associated signaling mechanism along with the new development in the prevention of herpes virus infection. I look forward to your contributions and to a valuable edition that will promote further developments in this exciting viral entry field. Thank you for your collaboration.

Assoc. Prof. Vaibhav Tiwari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • virus entry
  • virus-cell interaction
  • virus glycoproteins
  • entry receptors
  • heparan sulfate
  • heparinase
  • herpesvirus latency and reactivation
  • cell-to-cell spread
  • actin cytoskeleton
  • novel entry receptor
  • screening of small molecules
  • cell signaling
  • and novel therapeutic interventions

Published Papers

There is no accepted submissions to this special issue at this moment.
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