Special Issue "Virulence Potential and Rapid Screening of Enteric Pathogens from the Environment"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 1302
Interests: host-pathogen interactions; cellular Microbiology; bacterial virulence and secretion systems; biology of bacterial persister/dormant cells; antibiotic persistence and resistance; bacterial evolution and pathogenicity; biofilm; gene regulation; functional genomics
Enteric pathogens are associated with mild to severe forms of diarrheal diseases. Different kinds of exotoxins including enterotoxins and cytotoxins produced by various entric bacterial pathogens are the leading cause of the disease. For example, cholera toxin, heat-labile or heat-stable toxin, and shiga toxin are the major virulence factors of toxigeneic Vibrio cholerae, enterotoxigenic Escherichia coli, and Shiga toxin producing E. coli and Shigella species, respectively. Bacterial secretion systems especially Type 3 and Type 6 are novel virulence detreminants as well. Colonization and/or invasion of host epithelial cells are prerequisite to virulence, and each bacterium expresses unique colonization factor(s) and metabolic enzymes to overcome the mucus barriers of the intestine. Many pathogens, like V. cholerae employs sialidase/neuraminidas to cleave the terminal silaic from host glycoconjugates/mucin to generate carbon and energy for survival. Contaminated water and foods are major sources of infection by the enteric pathigens. Rapid and effective methods of screening and identification for these pathogens from the suspected environments/samples are thus very important. There are many methods including genetic (PCR, multilocus sequence typing), biochemical, and immunological are currently in use, however, many of them are expensive as they need sophisticated equipments like sequencer, thermal cycler etc, time consuming, and/or have poor accuracy and reproducibility. Therefore, development of rapid, cost-effective, and easy to use techniques are still needed for accurate and definitive identification of enteric pathogens from the environment. Moreover, methods for the identification of dormant bacteria which are tolerant to almost all conventional antibiotics and responsible for recalcitrant of infection are lacking.
To make substantial progress in better understanding the virulence potential or to dscover new virulence detreminats and developing rapid screening methods for enteric pathogens, it is highly encouraged to submit original research Articles, Communications, or Reviews in this special issue of Pathogens. All submitted papers will undergo a standard independent peer-review process.
Dr. Nityannada Chowdhury
Manuscript Submission Information
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- Enteric Bacteria
- Secretion system
- Screening Method
- Dormant bacteria