Special Issue "Cancer-Associated Cachexia and Nutrition Wasting: The Role of Nutritional Interventions"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: 15 August 2021.

Special Issue Editor

Dr. James A. Carson
Guest Editor
College of Health Professions, University of Tennessee Health Science Center, Memphis, TN, USA

Special Issue Information

Dear Colleagues,

Cachexia is the unintentional loss of bodyweight and muscle mass that reduces cancer treatment success, survival, and patient life quality. This wasting syndrome is also characterized by muscle mass loss and has several characteristics connected to the syndrome's progression, including malnutrition, hypogonadism, systemic inflammation, and metabolic dysfunction. While increased caloric intake alone is not sufficient to treat cachexia, malnutrition is prevalent in patients and can accelerate cachexia progression.  Despite progress in understanding cancer cachexia's etiology, there is a critical need for additional therapeutic options to prevent or reverse the syndrome, including nutritional-based therapies. Studies to examine novel nutritional approaches will provide vital mechanistic knowledge to address this gap in cancer care. The purpose of this special issue is to highlight the role of dietary interventions during cancer cachexia progression. Areas of emphasis include nutrition interactions with specific cancer types, interaction with cancer treatment, and stage of cachexia (pre-, cachexia, refractory cachexia) at the initiation of the intervention.  The second area of emphasis is on energy intake, and nutrient needs during cachexia progression and how these factors interact with cancer induces disruptions to systemic metabolism and inflammation.  Another focus of this issue is the examination novel of nutraceutical and supplement administration on systemic and skeletal muscle metabolism at different stages of cachexia progression and cancer treatment. Lastly, the issue will highlight nutritional interventions' potential to be a critical component of multimodal treatment strategies for cachexia involving various behavior interventions such as exercise, timed eating, sleep, and pharmacological interventions to prevent the progression of cachexia. Given cancer cachexia’s multifactorial condition, multimodal approaches are of great interest.

Dr. James A. Carson
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • malnutrition
  • wasting syndrome
  • metabolic dysfunction
  • muscle mass
  • cachexia
  • nutraceuticals
  • anti-inflammatory
  • physical activity

Published Papers

This special issue is now open for submission.
Back to TopTop