Effects of Phytochemicals on Gastrointestinal Disorders

Dear Colleagues,

Phytochemicals play a crucial role in modulating gastrointestinal health, primarily through their anti-inflammatory and antioxidant properties. These bioactive compounds exert their beneficial effects through multiple pathways, directly and indirectly promoting barrier integrity, microbial homeostasis, and balanced immune activity in the gut.

They are capable of influencing key signaling pathways that are central to the control of oxidative stress and inflammation in conditions such as gastritis, gastric ulcer, inflammatory bowel diseases (IBDs), irritable bowel syndrome (IBS), and gastrointestinal cancer. Furthermore, the complex interplay between dietary phytochemicals and the gut microbiome determines their bioavailability and therapeutic efficacy, either directly or through the production of metabolites.

Growing preclinical and clinical evidence highlights the potential of polyphenols, flavonoids, terpenoids, and other phytochemical classes in alleviating intestinal disorders. However, a deeper understanding of their mechanisms of action, optimal dosing, and long-term impacts is essential for translating these findings into safe and effective nutritional or therapeutic interventions.

This Special Issue invites researchers to contribute original research and comprehensive review articles that explore the multifaceted effects of phytochemicals on gastrointestinal pathophysiology. We welcome studies that elucidate mechanisms, evaluate efficacy in experimental or clinical settings, and investigate interactions with the gastrointestinal ecosystem.

We look forward to receiving your valuable contributions.

Sincerely,

Prof. Dr. Sergio Faloni de Andrade
Guest Editor

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