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Special Issue "New Aspects of Quantitative Nutrition: Assessment of Glycaemic Variability and Control Quality through Continuous or Repeated Glucose Monitoring in Subjects That Undergo Dietary Interventions"

A special issue of Nutrients (ISSN 2072-6643).

Deadline for manuscript submissions: 15 March 2019

Special Issue Editor

Guest Editor
Dr. Andrea Tura

Metabolic Unit, Institute of Neuroscience, National Research Council, Corso Stati Uniti 4, 35127 Padova, Italy
Website | E-Mail
• Analysis of sequences of data, with special interest to Continuous Glucose Monitoring data (CGM) for the estimation of glycemic control and glycemic variability
• Glucose monitoring through non-invasive techniques, with special focus on electro-impedance spectroscopy approach
• Monitoring of glucose and sodium concentration during dialysis, through electro-impedance spectroscopy coupled with ion-exchange resins
• Mathematical models and methods for quantitative physiology and quantitative clinical tests, particularly in the field of chronic diseases, such as Type 2 Diabetes and related cardiovascular diseases. Special interest is on models of pancreatic beta-cell function and insulin sensitivity
• Telemedicine for home monitoring of subjects requiring continuous, non-ending health care, based on the use of portable and wearable medical instruments

Special Issue Information

Dear Colleagues,

Glycaemic variability and control quality are emerging as important factors of diabetes control. Glycaemic variability is defined as the degree of fluctuations that glycaemia undergoes, during a glucose tolerance test, or, more often, during a long period of time (one or more days). Glycaemic control quality is defined as the degree of maintenance of glycaemia within a target range. Glycaemic variability and control quality can nowadays be assessed by different technological approaches. Indeed, some devices are available for continuous or flash glucose monitoring (CGM or FGM), which allows automatic measurement of glucose in the interstitial fluids (acceptable marker of blood glucose) with frequent sampling (one measure every few minutes) or upon request. On the other hand, even self-monitoring of blood glucose, with the traditional fingersticks, with measurement of blood glucose four to six times per day, when prolonged for long periods may allow collecting sufficient data for the assessment of glycaemic variability and control quality.

Increasing studies have shown that glycaemic variability and control quality (especially the former) are risk factors for diabetic complications. Indeed, studies in vitro showed that glycaemic variability could increase the production of reactive oxygen species and has a detrimental effect on endothelial dysfunction. Furthermore, some clinical studies have suggested that glycaemic variability may directly contribute to the pathogenesis of cardiovascular diseases. Specifically, some studies showed that the intraday glycaemic variability is associated with the presence and severity of coronary artery disease in patients with type 2 diabetes, and, more generally, blood glucose excursions may play an important role in the occurrence and development of atherosclerosis in diabetes. In addition, it was hypothesized that minimizing glycaemic variability is effective in improving the insulin resistance, as well as intima-media thickness, which are associated directly with cardiovascular diseases.

On the other hand, there is increasing evidence that adequate dietary advice or, more effectively, individualized nutrition therapy, is of importance for the prevention and the management of type 2 diabetes. Indeed, some studies showed that individualized nutrition therapy provided by dietitians, compared with dietary advice provided by other health professionals, leads to greater beneficial effects on HbA1c, weight, and cholesterol. In more details, the concept of precision nutrition has also emerged, based on the hypothesis that dietary interventions can be tailored to an individual's genetic background, metabolic profile, and environmental exposures. Indeed, recent advances in genomics, metabolomics, and gut microbiome studies have shown opportunities for the use of precision nutrition to prevent and manage type 2 diabetes.

However, studies focusing on the effect of dietary interventions on glycaemic variability and control quality are still rare. The aim of this Special Issue is, therefore, to invite the submission of studies addressing these topics. More specifically, topics of interest are the following:

  • Assessment of glycaemic variability and control quality in subjects that underwent dietary intervention, with special reference to subjects with diabetes or impaired glucose metabolism
  • Effect of single nutrients on glycaemic variability and control quality, in subjects with metabolic abnormalities, but also in still healthy subjects
  • Short versus prolonged dietary intervention or single nutrient supply: what consequences on glycaemic variability and control quality
  • Continuous glucose monitoring versus traditional self-monitoring of blood glucose: advantages and disadvantages for the assessment of glycaemic variability and control quality in subjects that underwent dietary intervention or nutrient supply
  • Indices and methodologies for the assessment of glycaemic variability and control quality in subjects under dietary intervention or nutrient supply: What are the most appropriate?

Dr. Andrea Tura
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Glycaemic variability
  • Glycaemic control quality
  • Continuous glucose monitoring
  • Self-monitoring of blood glucose
  • Type 2 diabetes
  • Impaired glucose metabolism
  • Cardiovascular disease
  • Dietary intervention
  • Nutrient supply
  • Individualized nutrition therapy
  • Precision nutrition

Published Papers

This special issue is now open for submission.
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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