Dear Colleagues,

Liver diseases, comprising both acute and chronic manifestations, account for approximately 2 million deaths worldwide each year. Although most of these deaths are related to the complications of chronic conditions such as cirrhosis and hepatocellular carcinoma (HCC), acute liver failure (ALF) is also a life-threatening event associated with high mortality globally. It is noteworthy that, when combined, liver-related deaths are responsible for 3.5% of all deaths worldwide. Liver diseases also have a high impact on healthcare systems, as the liver is the second most common solid organ transplanted due to disease outcomes. Among these conditions, alcohol-associated liver disease (AALD), non-alcoholic fatty liver disease (NAFLD), viral hepatitis, autoimmune hepatitis, Wilson’s disease, cholangitis, cholangiocarcinoma, drug-induced liver injury, as well as end-stage cirrhosis and HCC are the most important liver diseases. Dietary patterns and drug use are directly related to a spectrum of liver diseases, contributing to both disease prevention and treatment, and to their establishment and progression. In this context, this Special Issue aims to unveil diet- and drug-induced morphological and molecular outcomes in acute or chronic liver diseases, welcoming both clinical and preclinical investigations. Mechanistic studies using state-of-the-art methodologies are especially welcome.

We look forward to your contributions!

Dr. Luís Fernando Barbisan
Prof. Dr. Guilherme Ribeiro Romualdo
Guest Editors

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• chronic liver diseases
• acute liver diseases
• drug-induced liver diseases
• diet-induced liver diseases
• liver cirrhosis
• hepatocarcinogenesis
• viral hepatitis
• preclinical studies
• clinical studies
• nutrition and liver disease