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Nanomaterials
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Current Review in Biology and Medicines
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Special Issue "Current Review in Biology and Medicines"

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (21 February 2023) | Viewed by 1768

Special Issue Editor

Prof. Dr. Eleonore Fröhlich

E-Mail Website
Guest Editor
Center for Medical Research, Medical University of Graz, Stiftingtalstraße 24, 8010 Graz, Austria
Interests: physiologically relevant culture models; automated microscopes for cell monitoring; life cell imaging; biological assessment of nano and microparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nanomaterials have been detected in the environment (air, water, soil) and in all domains of life (bacteria, archaea, eukaryota). Direct adverse effects with potential changes in their normal composition and accumulation of nanoparticles in different organisms may affect protists, plants, fungi and animals. In addition to exposure by the environment, use of nanomaterials in agriculture, healthcare and medicine increases. This Special Issue aims to collect reviews that cover biological effects of nanomaterials with a focus on the common principles or differences in the mode of action between organisms or individuals, interaction with toxicants, and adaptive responses.

Prof. Dr. Eleonore Fröhlich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanotoxicity
  • chronic effects
  • interaction with toxicants
  • agriculture
  • aqueous environment
  • medical applications
  • inter-species differences
  • invertebrates
  • plants

Published Papers (1 paper)

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Research

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Article
Comparative Study between Curcumin and Nanocurcumin Loaded PLGA on Colon Carcinogenesis Induced Mice
by
Farida E. Elbassiouni
,
Wafaa M. El-Kholy
,
El-Sayed M. Elhabibi
,
Sarah Albogami
and
Eman Fayad
Nanomaterials 2022, 12(3), 324; https://doi.org/10.3390/nano12030324 - 20 Jan 2022
Cited by 7 | Viewed by 1162
Abstract
Colorectal cancer is the third most common cancer. Because curcumin (CUR) has anti-inflammatory and anticancer properties, research has been undertaken to indicate that nanocurcumin compounds can be used to treat a variety of cancers. CUR in nanoform has been found to have a [...] Read more.
Colorectal cancer is the third most common cancer. Because curcumin (CUR) has anti-inflammatory and anticancer properties, research has been undertaken to indicate that nanocurcumin compounds can be used to treat a variety of cancers. CUR in nanoform has been found to have a stronger effect than conventional CUR. The purpose of this study was to show that CUR-loaded poly lactic-co-glycolic acid nanoparticles (PLGA) (CUR-loaded PLGA) have anti-inflammatory and anticancer effects on colon carcinogenesis in male dimethyl hydrazine (DMH) mice as a comparative study between the nanoform of curcumin and normal curcumin, focusing on the anticancer effect of nanocurcumin. Mice were separated into six groups: No treatment was given to Group I (negative Group-I). Group II was treated with CUR. Group III was treated with CUR-loaded PLGA. Group IV was treated with DMH. Group V received DMH and curcumin. Group VI received DMH and CUR-loaded PLGA. At the conclusion of the trial, the animals were slain (6 weeks). Inflammatory indicators and vascular endothelial growth factor (VEGF) levels all changed significantly in this study, as the following inflammatory markers as TNF showed percent of change compared to the DMH group. Recovery percentage for Groups V and VI, respectively, were 9.18 and 55.31%. In addition, IL1 was 7.45 and 50.37% for Groups V and VI, respectively. The results of IL6 were 4.86 and 25.79% for Groups V and VI, respectively. The vascular endothelial growth factor (VEGF) recovery percent was 16.98 and 45.12% for Groups V and VI, respectively. Following the effect of DMH on colon mucosa shape, the researchers looked at the effect of CUR-loaded PLGA on colon histology. It was shown that CUR-loaded PLGA affects the cell cycle and PCNA expression. We conclude that nanocurcumin is an important anti-inflammatory and cancer-fighting agent. Full article
(This article belongs to the Special Issue Current Review in Biology and Medicines)
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