Special Issue "Modulation of Quorum Sensing in Bacteria"
Deadline for manuscript submissions: closed (30 June 2020).
Interests: Biologically active molecules; Heterocyclic chemistry; Medicinal chemistry; Design and synthesis of quorum-sensing inhibitors; antimicrobial peptides and mimics; Biomimetic synthesis; Development of new synthetic methodologies; antimicrobial biomaterials
Special Issues and Collections in MDPI journals
Special Issue in Molecules: Design and Synthesis of Quorum-Sensing Inhibitors
Special Issue in Molecules: Recent Advances in Antimicrobial Biomaterials
With the long-term overuse and misuse of antibiotics, the problem of antibiotic resistance is now reaching a critical stage. Antibiotics are no longer the magic bullets they were once thought to be, and therefore there is an urgent need for the development of alternative therapeutic strategies to combat infections without inducing drug resistance. Quorum sensing (QS) modulation presents a promising alternative strategy, since it attenuates bacterial virulence by disrupting the signaling pathway between bacteria without inducing stress.
Several strategies to combat this problem are discussed:
i) The isolation of new natural products with quorum sensing (QS) modulatory activities and the development of their synthetic analogues;
ii) The synthesis of new classes of QS modulators with anti-virulence and anti-biofilm properties;
iii) The rational design and structure–activity relationship studies of QS modulators;
iv) Applications and targeted delivery;
v) Dual-action and hybrid compounds;
vi) The synergistic activities of these compounds with other antimicrobials.
The aim of the Special Issue is to be inclusive and especially to encourage the publication of new and unusual chemical structures with quorum sensing modulation properties.
Molecules will publish a Special Issue focusing on the “Modulation of Quorum Sensing in Bacteria”, as well as novel molecular targets with reduced capacity to develop antibiotic resistance. It is my pleasure to invite submissions of high-quality research-based papers related to the topics mentioned above.
Prof. Naresh Kumar
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.