Special Issue "Integrins: Structure, Ligands and Interactions"
Deadline for manuscript submissions: 1 August 2019
Prof. Alessandra Tolomelli
Department of Chemistry “G.Ciamician”, University of Bologna, Via Selmi, 2, Bologna-40126, Italy
Website | E-Mail
Phone: 0039 051 2099575
Interests: Design and synthesis of bioactive peptides/peptidomimetics targeting PPI; Conjugation of bioactive peptides/peptidomimetics with drugs/diagnostics; Novel methodologies for sustainable peptide synthesis; Design and synthesis of β-amino acid-containing heterocycles as a scaffold for bioactive peptidomimetics
The extensive research carried out on integrins in recent decades sheds light on their paramount role in several pathologies. Being responsible for bidirectional signaling between cells and the extracellular matrix, these transmembrane receptors play a key regulatory action in adhesive events and intracellular pathways. Among the 24 different members of the family, some are overexpressed on cancer cells and are important players in primary tumor formation and metastasis anchorage, while other subtypes take part in platelet recruitment and aggregation processes, regulating hemostasis. Finally, leukocyte integrins are involved in inflammatory and immune response regulations.
Modulation of integrin signaling by agonists or antagonists clearly represents an opportunity to affect cellular functions. On the other hand, the selective recognition of specific cells can design drug delivery systems and diagnostics, through conjugation of integrin targeting molecules with cytotoxic fragments or detectable reporters. At the same time, deep investigations on the ligand-induced conformational changes and on the fate of ligands in a cellular environment provide important information on still elusive aspects of receptor internalization and selective biopathway activation. In this area, small peptides and peptidomimetics, acting as protein–protein interaction regulators, have been designed on the basis of the minimal recognition sequences between integrins and extracellular matrix ligands, affording new tools both for therapeutic and diagnostic purposes. This Special Issue is focused on the most recent research in the design and development of new ligands for therapeutic/diagnostic and theranostic applications, and on the investigation of the intracellular events induced by ligand-receptor binding.
Prof. Alessandra Tolomelli
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- PPI regulation
- Selective ligands
- Agonist vs antagonist behavior
- Bioactive conformations