Special Issue "Bacterial Type IV Secretion Systems"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 31 October 2019

Special Issue Editor

Guest Editor
Prof. Dr. Günther Koraimann

Institute of Molecular Biosciences, Karl-Franzens-Universitat Graz, Graz, Austria
Website | E-Mail
Interests: horizontal gene transfer; antimicrobial resistance; enterobacteria; gene regulation; transcriptional activators; bacterial conjugation; F-like plasmids

Special Issue Information

Dear Colleagues,

Type IV Secretion Systems (T4SS) are versatile bacterial trans-envelope transporters which are highly complex, both structurally and functionally. Functions of T4SS range from secretion of toxins targeting eukaryotic cells or bacterial competitors to transport of single-stranded DNA during bacterial conjugation. T4SS also facilitate DNA uptake or release in some bacterial species and transport of tumorigenic DNA and proteins from Agrobacterium tumefaciens into plant cells. A very important function is the direct transport of effector proteins from pathogenic bacteria such as Helicobacter pylori or Legionella pneumophila directly into eukaryotic host cells. Thus, for some symbionts and intracellular pathogens, T4SS are essential for the survival in the host. Despite the plethora of functions and their wide distribution in Gram-positive and Gram-negative bacteria, T4SS share a common evolutionary ancestry. This Special Issue focuses on recent progress in this dynamic research field, including transport mechanisms, selection of effectors, structure and function of effector proteins, function of ATPases and other components in substrate translocation, structural composition of T4SS or components thereof, and assembly of T4SS and regulation of the expression of T4S genes. Topics that will be equally considered are novel T4SS and their function in host–pathogen interactions as well as the identification of drug targets and possible inhibitors of T4SS.

Prof. Dr. Günther Koraimann
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Effector translocation
  • Macromolecular transporters
  • Bacterial protein secretion
  • Bacterial conjugation
  • Host–pathogen interactions
  • DNA secretion and uptake
  • Cell envelope

Published Papers

This special issue is now open for submission.
Microorganisms EISSN 2076-2607 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top