Epidemiology, Detection and Control of Avian Infectious Diseases

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Veterinary Microbiology".

Deadline for manuscript submissions: 15 March 2026 | Viewed by 704

Special Issue Editor


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Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China
Interests: avian infectious diseases; antimicrobial resistance; one health perspectives; vaccine development; zoonoses

Special Issue Information

Dear Colleagues,

Avian infectious diseases continue to pose significant threats to poultry and public health and food security worldwide. Understanding their epidemiology, improving methods for their detection, and developing effective control strategies are critical for disease prevention and sustainable poultry production.

This Special Issue aims to compile high-quality research and review articles focused on the surveillance, diagnosis, pathogenesis, and control of avian infectious diseases. We hope to provide a platform for advancing scientific knowledge and facilitating global collaboration to improve avian disease control strategies.

The topics of interest for this Special Issue include, but are not limited to, molecular and serological diagnostic techniques, vaccine development, antimicrobial resistance, host–pathogen interactions, biosecurity practices, and One Health perspectives. Submissions that explore emerging avian pathogens or zoonotic transmission are also encouraged.

Dr. Wenjie Jin
Guest Editor

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Keywords

  • avian infectious diseases
  • antimicrobial resistance
  • One Health perspectives
  • vaccine development
  • zoonoses

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Published Papers (2 papers)

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Research

12 pages, 2186 KB  
Article
Isolation and Characterization of a Duck Hepatitis A Virus Type 3 SH52 Strain in Ducklings
by Minfan Huang, Dun Shuo, Yifei Xiong, Mei Tang, Yufei Wang, Xue Pan, Chunxiu Yuan, Qinfang Liu, Zhifei Zhang, Qiaoyang Teng, Bangfeng Xu, Xiaona Shi, Minghao Yan, Peirong Jiao, Zejun Li and Dawei Yan
Microorganisms 2025, 13(12), 2652; https://doi.org/10.3390/microorganisms13122652 - 22 Nov 2025
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Abstract
Duck hepatitis A virus type 3 (DHAV-3), an avian-specific pathogen primarily impacting ducklings, poses a significant threat to the duck farming industry by causing high mortality rates. A DHAV-3 strain SH52 was isolated from the diseased ducks and phylogenetic analysis of the whole [...] Read more.
Duck hepatitis A virus type 3 (DHAV-3), an avian-specific pathogen primarily impacting ducklings, poses a significant threat to the duck farming industry by causing high mortality rates. A DHAV-3 strain SH52 was isolated from the diseased ducks and phylogenetic analysis of the whole genome revealed that the DHAV-3 SH52 belongs to the prevalent strains in China. The DHAV-3 SH52 strain replicates at high levels in various organs of 8-day-old specific pathogen-free (SPF) shelducks, causing pathological damage and leading to high lethality in 8-day-olds following intramuscular infection. The findings of this study provide an ideal animal challenge model for evaluating the efficacy of DHAV-3 vaccines in the future. Full article
(This article belongs to the Special Issue Epidemiology, Detection and Control of Avian Infectious Diseases)
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11 pages, 1841 KB  
Article
Pathogenicity Evaluation and Virulence Gene Identification of an Attenuated Duck Enteritis Virus
by Xiaona Shi, Haibin Zhuang, Dun Shuo, Luzhao Li, Shenghui Pan, Zihua Wu, Mei Tang, Wenxia Yang, Qinfang Liu, Chunxiu Yuan, Dawei Yan, Xue Pan, Bangfeng Xu, Zhifei Zhang, Minghao Yan, Qiaoyang Teng and Zejun Li
Microorganisms 2025, 13(11), 2537; https://doi.org/10.3390/microorganisms13112537 - 5 Nov 2025
Viewed by 333
Abstract
Duck enteritis virus (DEV), an epornitic pathogen, causes substantial economic losses in the commercial duck industry and poses persistent risks to wild and migratory waterfowl populations. However, due to the large genomic capacity of the DEV, the understanding of the virulence-associated genes of [...] Read more.
Duck enteritis virus (DEV), an epornitic pathogen, causes substantial economic losses in the commercial duck industry and poses persistent risks to wild and migratory waterfowl populations. However, due to the large genomic capacity of the DEV, the understanding of the virulence-associated genes of DEV is still limited. In previous studies, we developed an attenuated strain E74 by serial passage of a virulent strain E1 on primary chicken embryo fibroblasts (CEFs). The bird experiment showed that the mortality rate of E1 on ducks reached 100%, and high-titered viruses were detected in all tested tissue samples. In contrast, the E74 virus has lost its pathogenicity in ducks and can only be detected at a relatively low viral load in the spleen. Furthermore, the E74 stimulated a significant increase in antibodies in the ducks at 7 days post-inoculation. To further investigate the molecular basis of the attenuation of DEV in ducks, the complete genomes of E74 and E1 were sequenced and analyzed. Compared with E1, E74 had a 5152 bp deletion in the UL region, which resulted in the lack of the hypothetical protein, LORF5, UL55 and LORF4 genes. To test the influence of the deletion on the viral pathogenicity, a rescued virus rE1-Δ5152 with the 5152 bp deletion in the UL region was generated on the E1 backbone. Animal experiments showed that the lethality of rE1-Δ5152 in ducks had disappeared. Those findings suggest that the hypothetical protein, LORF5, UL55, and LORF4 genes of DEV are associated with virus virulence, and the flexibility of this region provided excellent insertion sites for exogenous genes when DEV is used as a recombinant vaccine vector. Full article
(This article belongs to the Special Issue Epidemiology, Detection and Control of Avian Infectious Diseases)
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