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Micromachines
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Biofabrication Frontiers
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Biofabrication Frontiers

A topical collection in Micromachines (ISSN 2072-666X). This collection belongs to the section "B2: Biofabrication and Tissue Engineering".

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Editor

Dr. Mohsen Akbari

E-Mail Website
Collection Editor
Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada
Interests: drug delivery; biomaterials; tissue engineering
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

Biofabrication Frontiers is a Topical Collection dedicated to showcasing cutting‑edge advances that are redefining how we design, build, and integrate biological structures using engineering, materials science, and microfabrication technologies. As emerging methods enable unprecedented control over cells, biomaterials, and microenvironments, this issue highlights innovative strategies—from microfluidic and 3D‑printing platforms to modular microgel systems and hybrid bioinks—that push biofabrication toward greater precision, scalability, and translational impact. Contributions will explore technologies that support large‑scale cell expansion, architected tissue assembly, organ‑mimetic constructs, and functional interfaces between living and synthetic components. Particular emphasis is placed on breakthroughs that bridge fundamental engineering with practical biomedical applications, including regenerative medicine, disease modeling, drug testing, and soft robotic systems. By gathering interdisciplinary work spanning microengineering, biomaterials, mechanobiology, and automation, Biofabrication Frontiers aims to serve as a comprehensive resource for researchers shaping the next generation of biomanufacturing and tissue engineering innovations.

Dr. Mohsen Akbari
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biofabrication
  • microfluidics
  • 3D bioprinting
  • biomaterials engineering
  • tissue manufacturing
  • organ on chip
  • cell laden hydrogels
  • microcarrier technologies
  • scaffold based tissue engineering
  • artificial intelligence

Published Papers (1 paper)

2026

33 pages, 817 KB  
Review
Evolutions in Cardiovascular Implants—A Review of Past, Present, and Future
by Callen Moon, Jay Ming Tong and Dake Hao
Micromachines 2026, 17(6), 703; https://doi.org/10.3390/mi17060703 - 8 Jun 2026
Cited by 1 | Viewed by 1597
Abstract
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, driving the continuous evolution of implantable cardiovascular therapies. Although early cardiovascular implants revolutionized the treatment of CVD, they are limited by restenosis, mechanical failure, poor biocompatibility, and inadequate tissue integration. These clinical limitations [...] Read more.
Cardiovascular disease (CVD) remains the leading cause of mortality worldwide, driving the continuous evolution of implantable cardiovascular therapies. Although early cardiovascular implants revolutionized the treatment of CVD, they are limited by restenosis, mechanical failure, poor biocompatibility, and inadequate tissue integration. These clinical limitations have driven the development of next-generation implants, with improved hemodynamic performance, regenerative potential, and long-term functionality. Advances in biomaterial science, tissue engineering, biosensors, wireless telemetry, flexible bioelectronics, and translational cardiovascular medicine have transformed cardiovascular implants from passive structural devices into biologically integrated and increasingly intelligent systems capable of interacting dynamically with the host cardiovascular environment. In this review, we summarize the historical evolution, current clinical applications, and emerging technologies of major cardiovascular implants. We further discuss key biological and engineering challenges limiting long-term clinical success and highlight future directions in regenerative biomaterials, smart bioelectronics, and personalized cardiovascular implants for next-generation cardiovascular therapy. Full article
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