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Facultad de Ciencias de la Ingeniería y Tecnología, Universidad Autónoma de Baja California, Tijuana 21500, Baja California, Mexico
Interests: tissue engineering; drug delivery systems; biotechnology; nanotechnology; electrospinning; biosensors
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Special Issue Information

Dear Colleagues,

The innovation in nanomaterials in several forms, structures, compositions, and applications has seen exponential growth over the past 10 years, and has been gaining more confidence in industry for the design and fabrication of biomedical devices that can be used as drug delivery systems, tissue engineering, and bioelectronic devices such as biosensors or organic solar cells. The choice and adequation of the optimal nanomaterial for a specific application with a cost-effective manufacturing process have been the objective of an increasing number of scientists worldwide. Additionally, the construction of nanostructures has increased many advantageous characteristics of conventional biomaterials by stimulating their bioactivity due to the accessibility of many tissues or increasing their surface area, leading to a higher load of a bioactive component, among other impacts. One example is the use of the electrospinning technique, which allows the fabrication of three-dimensional fibrous nanostructures that simulate tissue’s extracellular matrix, which promotes cell proliferation. Accordingly, this Special Issue seeks to showcase research papers and review articles that focus on novel methodological developments in nano-scale fabrication, novel synthesis processes, chemical compositions, nanostructures, coatings, or bioactivity and tissue response in the fields of the application of tissue engineering, drug delivery systems, and biomedical devices.

We look forward to receiving your submissions!

Dr. Luis Jesús Villarreal-Gómez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Micromachines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

nanomaterials
biodevices
tissue engineering
drug delivery systems
biosensors
nanotechnology

Published Papers (2 papers)

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Research

Jump to: Review

Open AccessArticle

Manufacturing of a Transdermal Patch in 3D Printing

Isabella Villota

Paulo César Calvo

Oscar Iván Campo

Luis Jesús Villarreal-Gómez

and

Faruk Fonthal

Micromachines 2022, 13(12), 2190; https://doi.org/10.3390/mi13122190 - 10 Dec 2022

Viewed by 903

Abstract

Diabetes mellitus is an endocrine disorder that affects glucose metabolism, making the body unable to effectively use the insulin it produces. Transdermal drug delivery (TDD) has attracted strong interest from researchers, as it allows minimally invasive and painless insulin administration, showing advantages over conventional delivery methods. Systems composed of microneedles (MNs) assembled in a transdermal patch provide a unique route of administration, which is innovative with promising results. This paper presents the design of a transdermal patch composed of 25 microneedles manufactured with 3D printing by stereolithography with a class 1 biocompatible resin and a printing angle of 0°. Finite element analysis with ANSYS software is used to obtain the mechanical behavior of the microneedle (MN). The values obtained through the analysis were: a Von Misses stress of 18.057 MPa, a maximum deformation of

2.179 \times 10^{- 3}

, and a safety factor of 4. Following this, through a flow simulation, we find that a pressure of 1.084 Pa and a fluid velocity of 4.800

\frac{m}{s}

were necessary to ensure a volumetric flow magnitude of

4.447 \times 10^{- 5} \frac{{cm}^{3}}{s}

. Furthermore, the parameters found in this work are of great importance for the future implementation of a transdermal drug delivery device. Full article

(This article belongs to the Special Issue Nanomaterials for Tissue Engineering and Drug Delivery Systems)

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Review

Jump to: Research

Open AccessReview

Hybrid Systems of Nanofibers and Polymeric Nanoparticles for Biological Application and Delivery Systems

Hever Yuritzy Vargas-Molinero

Aracely Serrano-Medina

Kenia Palomino-Vizcaino

Eduardo Alberto López-Maldonado

Luis Jesús Villarreal-Gómez

Graciela Lizeth Pérez-González

and

José Manuel Cornejo-Bravo

Micromachines 2023, 14(1), 208; https://doi.org/10.3390/mi14010208 - 14 Jan 2023

Cited by 1 | Viewed by 1040

Abstract

Nanomedicine is a new discipline resulting from the combination of nanotechnology and biomedicine. Nanomedicine has contributed to the development of new and improved treatments, diagnoses, and therapies. In this field, nanoparticles have notable importance due to their unique properties and characteristics, which are useful in different applications, including tissue engineering, biomarkers, and drug delivery systems. Electrospinning is a versatile technique used to produce fibrous mats. The high surface area of the electrospun mats makes them suitable for applications in fields using nanoparticles. Electrospun mats are used for tissue engineering, wound dressing, water-treatment filters, biosensors, nanocomposites, medical implants, protective clothing materials, cosmetics, and drug delivery systems. The combination of nanoparticles with nanofibers creates hybrid systems that acquire properties that differ from their components’ characteristics. By utilizing nanoparticles and nanofibers composed of dissimilar polymers, the two synergize to improve the overall performance of electrospinning mats and nanoparticles. This review summarizes the hybrid systems of polymeric nanoparticles and polymeric nanofibers, critically analyzing how the combination improves the properties of the materials and contributes to the reduction of some disadvantages found in nanometric devices and systems. Full article

(This article belongs to the Special Issue Nanomaterials for Tissue Engineering and Drug Delivery Systems)

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