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Metabolites publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Metabolic Regulation of Reproductive Physiology in Livestock Species

edited by

Gabriele Brecchia

Giulio Curone

and Stella Agradi

submission deadline 31 Dec 2025 | Viewed by 537 | Submission Open

Keywords: metabolic regulation; reproductive physiology; livestock reproduction; energy balance; nutrient me-tabolism; fertility biomarkers; hormonal regulation; metabolic disorders; reproductive efficiency

(This special issue belongs to the Section Animal Metabolism)

Metabolic Reprogramming in Cancer: New Frontiers for Therapeutic Intervention

edited by Songhua Hu, Yahui Wang and

Daniel Oscar Cicero

submission deadline 31 Dec 2025 | Viewed by 471 | Submission Open

Keywords: cancer metabolism; metabolic reprogramming; metabolic plasticity; cancer heterogeneity; therapeutic resistance; tumor microenvironment; combination therapies

(This special issue belongs to the Section Cell Metabolism)

Myostatin: A Key Regulator of Skeletal Muscle Metabolism and Development

edited by

Emiliano Lasagna

and

Ishaku L. Haruna

submission deadline 31 Dec 2025 | Viewed by 446 | Submission Open

Keywords: myostatin; MSTN; GDF8; muscle development; muscular hypertrophy; metabolites and metabolism; omics sciences; myostatin pathways

(This special issue belongs to the Section Animal Metabolism)

Metabolomics and MASLD: Pathways, Biomarkers, and Clinical Insights

edited by

Amedeo Lonardo

and

Ralf Weiskirchen

submission deadline 31 Dec 2025 | Viewed by 403 | Submission Open

Keywords: amino acids; bile acids; cardiovascular disease; cholesterol; ceramides; cirrhosis; diabetes; eicosanoids; HIV; hyper-tension; insulin resistance; lipidome; lipidomics; lipotoxicity; liver fibrosis; MASLD/MASH; metabolome; metabolomics; microbiome; NAFLD/NASH omics; obesity; precision medicine; phospholipids; sphingolipids; triglycerides; SCFA; tar-geted metabolomics; TMAO; uric acid; HCC; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Mitochondrial Metabolism, Redox State and Immunology in Cancer

edited by

Alfredo Cruz-Gregorio

and

Gladis Fragoso

submission deadline 31 Dec 2025 | Viewed by 337 | Submission Open

Keywords: immune system; mitochondria; redox state; cancer

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolites in Animal Nutrition and Physiological Regulations Under Stress Conditions

edited by

Hieu Huu Le

and

Majid Shakeri

submission deadline 31 Dec 2025 | Viewed by 329 | Submission Open

Keywords: metabolic; nutrition; amino acids; meat quality; metabolites; fatty acids; non-esterified fatty acids (NEFA); physiology; metabolism; dietary supplementation

(This special issue belongs to the Section Animal Metabolism)

Women’s Special Issue Series: Metabolomic Profiling Technology

edited by

Thusitha W. Rupasinghe

and

RuAngelie Edrada-Ebel

submission deadline 31 Dec 2025 | Viewed by 298 | Submission Open

Keywords: metabolomics; metabolomic profiling technology; metabolism; analytical chemistry; NMR; mass spectrometry

(This special issue belongs to the Section Metabolomic Profiling Technology)

Obesity and Metabolic Syndrome in Children: Insights, Interventions and Emerging Perspectives, 2nd Edition

edited by

Teofana Otilia Bizerea-Moga

and Rade Vukovic

submission deadline 31 Dec 2025 | Viewed by 212 | Submission Open

Keywords: metabolic syndrome in children; childhood obesity; hypertension; glucose tolerance; insulin resistance; nutritional status; metabolomics; oxidative stress; trace elements— selenium

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Phytochemicals on Human Metabolism

edited by

Henrique Cerqueira

and

Eric Gumpricht

submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open

Keywords: phytochemistry; bioactive compounds; metabolism; nutritional interventions; energy balance; oxidative stress; inflammation

(This special issue belongs to the Section Nutrition and Metabolism)

MicroRNAs in Lipid Metabolism

edited by Pablo Fernández-Tussy

submission deadline 31 Dec 2025 | Viewed by 135 | Submission Open

Keywords: microRNAs; lipid metabolism; lipoproteins; obesity; atherosclerosis

(This special issue belongs to the Section Lipid Metabolism)

Application of Urinary Metabolomics in Early Disease Detection

edited by

Casey Burton

submission deadline 31 Dec 2025 | Viewed by 132 | Submission Open

Keywords: urinary metabolomics; biomarkers; early disease detection; analytical method development; therapeutic response monitoring

(This special issue belongs to the Section Advances in Metabolomics)

Role of Cell Metabolism in Infective Diseases

edited by

Chongshan Dai

submission deadline 31 Dec 2025 | Viewed by 94 | Submission Open

Keywords: metabolites; immunology; drug therapy; new compounds; cellular metabolism; infectious diseases

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Chemical Exposure on Endocrine and Reproductive Functions, 2nd Edition

edited by Renata Marino Romano and Caroline Serrano-Nascimento

submission deadline 31 Dec 2025 | Viewed by 67 | Submission Open

Keywords: endocrine-disrupting chemicals exposure impact on metabolic diseases; reproductive failure; infertility; endocrine disorders

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Food Intake and Bioactive Metabolism in Humans

edited by Anallely López-Yerena and Emily P. Laveriano Santos

submission deadline 15 Jan 2026 | 3 articles | Viewed by 3868 | Submission Open

Keywords: bioactive compounds; phytochemical; carotenoids; polyphenols; oxylipins; gut microbiota; bioavailability; personalized nutrition; functional foods; disease prevention

(This special issue belongs to the Section Nutrition and Metabolism)

Cardiovascular Biomarkers and Metabolism in Cardiovascular Diseases

edited by Mark G. Filipovic, Corina Manuela Bello and Markus M. Luedi

submission deadline 15 Jan 2026 | 1 articles | Viewed by 2002 | Submission Open

Keywords: cardiovascular; biomarkers; risk factors; outcome; prognostication; metabolism; metabolomics; risk markers

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

LC-MS/MS Analysis for Plant Secondary Metabolites, 2nd Edition

edited by Tiantian Ye

submission deadline 15 Jan 2026 | 1 articles | Viewed by 962 | Submission Open

Keywords: liquid chromatography; mass spectrometry; secondary metabolites; metabolomics; abiotic and biotic stress; plant development

(This special issue belongs to the Section Plant Metabolism)

Intestinal Health and Metabolites in Farm Animals—2nd Edition

edited by

Qian Jiang

and Junquan Tian

submission deadline 19 Jan 2026 | Viewed by 91 | Submission Open

Keywords: metabolites; intestinal health; oxidative stress; inflammation; epithelial barrier

(This special issue belongs to the Section Animal Metabolism)

Machine Learning in Metabolomics: Unlocking the Future of Data Analysis

edited by

Boryana Petrova

and Arzu Tugce Guler

submission deadline 23 Jan 2026 | 2 articles | Viewed by 3357 | Submission Open

Keywords: metabolomics; MS imaging; machine learning; AI; multi-omics; integration; biomarker discovery; compound annotation; spectra interpretation

(This special issue belongs to the Section Bioinformatics and Data Analysis)

Interactions Between Exercise Physiology and Metabolism

edited by

Lijing Gong

and Enming Zhang

submission deadline 31 Jan 2026 | 6 articles | Viewed by 8513 | Submission Open

Keywords: exercise; metabolism; physical activity; chronic disease prevention; exerkines

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolic Dysregulation in Fatty Liver Disease

edited by Ambrin Farizah Babu and

Youfei Guan

submission deadline 31 Jan 2026 | 3 articles | Viewed by 8173 | Submission Open

Keywords: metabolic dysregulation; metabolic homeostasis; insulin resistance; oxidative stress; lipid metabolism; glucose metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolism and Nutrition in Fish

edited by

Lei Wang

, Peng Tan and Rantao Zuo

submission deadline 31 Jan 2026 | 4 articles | Viewed by 7866 | Submission Open

Keywords: fish; metabolism; nutrition; feed additives; lipid; protein; requirements

(This special issue belongs to the Section Animal Metabolism)

Comprehensive Insights into Metabolic Pathways: Genome-Scale Modeling Techniques

edited by

Priyanka Baloni

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5122 | Submission Open

Keywords: metabolism; systems biology; genome-scale metabolic modeling; multi-omics data; data integration; data analysis; metabolic regulation; biomarker; drug targets

(This special issue belongs to the Section Advances in Metabolomics)

Clinical Nutrition and Metabolic Diseases

edited by

Desirée Victoria-Montesinos

Ana María García-Muñoz

and

José Francisco López-Gil

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4880 | Submission Open

Keywords: clinical nutrition; metabolic disorders; nutritional intervention; metabolic health; disease prevention; biomarkers; nutritional therapy

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolomic Fingerprinting: Challenges and Opportunities

edited by Christina Virgiliou and

Olga-Angeliki Begou

submission deadline 31 Jan 2026 | 2 articles | Viewed by 4730 | Submission Open

Keywords: metabolomics/metabonomics; mass spectrometry; metabolome; HRMS; hyphenated techniques

(This special issue belongs to the Section Integrative Metabolomics)

Psoriasis and Metabolic Syndrome

edited by Anna Baran

submission deadline 31 Jan 2026 | 3 articles | Viewed by 4298 | Submission Open

Keywords: psoriasis; psoriatic arthritis; metabolic diseases; genetic and epigenetic factors; markers; therapy; immunology; pathogenesis; lipids

(This special issue belongs to the Section Lipid Metabolism)

Liver Injury and Regeneration—Metabolic Research

edited by Miguel Suárez Matías

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3503 | Submission Open

Keywords: metabolism-associated steatotic liver disease; metabolic syndrome; chronic liver disease; liver fibrosis; hepatocellular carcinoma; metabolomic; endoscopy; non-invasive liver disease assessment; artificial intelligence; machine learning

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Advances in Phytomedicine Intervention on Metabolic Disorders

edited by

Hong Qin

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2164 | Submission Open

Keywords: metabolic disorders; glucose and lipid metabolism; insulin resistance; non-communicable diseases; energy imbalance; nutrients; phytochemicals; plant ac-tive components; inflammation; signaling pathway

(This special issue belongs to the Section Nutrition and Metabolism)

Current Research in Metabolic Syndrome and Cardiometabolic Disorders

edited by

Ciprian Ilie Rosca

and

Yunping Qiu

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1284 | Submission Open

Keywords: metabolic syndrome; obesity; dyslipidemias; hyperuricemia; diabetes mellitus; cardiovascular diseases; heart failure; arrythmias; acute or chronic coronary syndromes; SGLT2-inhibitors; metabolic liver diseases; COVID-19 infection

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Artificial Intelligence and Machine Learning in Metabolomics

edited by

Robert Winkler

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1271 | Submission Open

Keywords: artificial intelligence; machine learning; deep learning; metabolomics; integrative approaches

(This special issue belongs to the Section Integrative Metabolomics)

The Impact of Polyphenols on Metabolic Health and Disease

edited by

Si Qin

and Kozue Sakao

submission deadline 31 Jan 2026 | 1 articles | Viewed by 880 | Submission Open

Keywords: polyphenols; metabolic diseases; molecular mechanisms; intervention; AI

(This special issue belongs to the Section Nutrition and Metabolism)

Plant Metabolome and Metabolomics

edited by

Subhash Minocha

submission deadline 31 Jan 2026 | 1 articles | Viewed by 718 | Submission Open

Keywords: metabolomics; LC/MS-based metabolomics; plant science; metabolic pathways; biotechnology applications; sustainable agriculture

Connections Between Nutrition, Epidemiology, and Metabolism

edited by

Kijoon Kim

submission deadline 31 Jan 2026 | 1 articles | Viewed by 585 | Submission Open

Keywords: nutritional epidemiology; metabolism; antioxidants; medicinal herbs; functional ingredients; chronic disease; public health

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Bioenergetics in Diet and Metabolism: Nutritional Pathways to Health

edited by

Cennet Yıldız

and

Xinhui Wang

submission deadline 31 Jan 2026 | Viewed by 234 | Submission Open

Keywords: bioenergetics; metabolic efficiency; energy metabolism; nutritional interventions; diet-induced thermogenesis; macronutrient composition; metabolic health; metabolic disorders; biothermodynamics; entropy

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Crosstalk in the Tumor Microenvironment

edited by

Drenka Trivanovic

Ristic Biljana

and

Vesna M. Ćorić

submission deadline 31 Jan 2026 | Viewed by 193 | Submission Open

Keywords: cancer; oncometabolites; tumor microenvironment; metabolic crosstalk

(This special issue belongs to the Section Cell Metabolism)

Metabolic Syndrome and Non-Alcoholic Liver Disease—Second Edition

edited by

Mircea-Catalin Fortofoiu

submission deadline 31 Jan 2026 | Viewed by 178 | Submission Open

Keywords: metabolic syndrome; non-alcoholic fatty liver disease (NAFLD); insulin resistance; obesity; type 2 diabetes; liver cirrhosis; dyslipidemia; NAFLD treatment; hepatic steatosis; cardiovascular risk

(This special issue belongs to the Section Lipid Metabolism)

Hypoxia and Its Role in Cellular Metabolism: Mechanisms and Implications

edited by Raja Gopal Reddy Mooli,

Hang Cheng

and

Nathan Lanning

submission deadline 31 Jan 2026 | Viewed by 158 | Submission Open

Keywords: oxygen; hypoxia; metabolism; Hypoxia Inducible Factors (HIFs); prolyl hydroxylase domain-containing enzymes (PHDs); metabolic regulation; glucose metabolism; fatty acid metabolism; TCA cycle; metabolites

(This special issue belongs to the Section Cell Metabolism)

Bioactive Metabolites from Fungal Endophytes Associated with Medicinal Plants

edited by

Zhong-Hua Tang

and Chun-Hao Chang

submission deadline 31 Jan 2026 | Viewed by 157 | Submission Open

Keywords: medicinal plants; fungal endophytes; bioactive metabolites; symbiotic interaction; biosynthetic gene clusters; plant– microbe co-evolution; natural product discovery; metabolomics; synthetic biology; antimicrobial activity

(This special issue belongs to the Section Plant Metabolism)

Metabolomic Strategies for Deep Systems Profiling Towards Biomarker Discovery and Precision Medicine

edited by

Silvia Valentinuzzi

and

Troy D. Wood

submission deadline 31 Jan 2026 | Viewed by 127 | Submission Open

Keywords: metabolomics; biomarker discovery; mass spectrometry; omics integration; molecular signatures; precision medicine

(This special issue belongs to the Section Integrative Metabolomics)

Nutritional Interventions and Lipid Metabolism

edited by

Cecilia Bender

and

Mariano Stornaiuolo

submission deadline 31 Jan 2026 | Viewed by 126 | Submission Open

Keywords: lipid metabolism; nutritional interventions; dietary fats; bioactive compounds; functional foods; chronic diseases; nutrigenomics; weight management; inflammation; personalized nutrition

(This special issue belongs to the Section Lipid Metabolism)

Zebrafish Models in the Study of Diabetes and Metabolic Dysfunction

edited by Liqing Zang

submission deadline 31 Jan 2026 | Viewed by 125 | Submission Open

Keywords: zebrafish; diabetes; obesity; metabolic dysfunction; insulin resistance; hyperglycemia; lipid metabolism; drug screening; nutraceuticals; gene editing; high-fat diet; metabolomics

(This special issue belongs to the Section Animal Metabolism)

Metabolism of Bioactives and Natural Products: 2nd Edition

edited by Kamila Misiakiewicz-Has, Barbara Wiszniewska and

Sylwia Rzeszotek

submission deadline 31 Jan 2026 | Viewed by 105 | Submission Open

Keywords: natural products; bioactive; medicinal plants; phytochemicals; isoflavones; triterpenes; coumarins; alkaloids; prebiotics; carotenoids; polyphenols; organosulfur compounds

(This special issue belongs to the Section Nutrition and Metabolism)

Metabolic Changes During Pre- and Post-Harvest Fruit and Vegetable Decay, Ripening and Senescence—2nd Edition

edited by

Analía Concellón

and

María José Zaro

submission deadline 2 Feb 2026 | 1 articles | Viewed by 959 | Submission Open

Keywords: pre- and post-harvest technology; bio-stimulants and abiotic stress; nutritional quality; metabolic pathway; bioactive compounds; chilling injury

(This special issue belongs to the Section Plant Metabolism)

Nutritional Metabolism and Metabolome in Plants

edited by

Chuanying Fang

and Kang Li

submission deadline 10 Feb 2026 | Viewed by 243 | Submission Open

Keywords: nutritional metabolism; metabolomic; plant growth; development; and stress responses; metabolism-environmental factor interactions; genetic and molecular mechanisms; applications of plant metabolites

(This special issue belongs to the Section Plant Metabolism)

Vitamin D Metabolism and Human Health

edited by

Magdalena Kowalówka

Marta Karaźniewicz-Łada

and

Ilona Górna

submission deadline 12 Feb 2026 | 2 articles | Viewed by 6498 | Submission Open

Keywords: vitamin D; metabolites vitamin D; metabolic pathways; metabolic perturbations; vitamin D receptor; enzymes; polymorphism; vitamin D deficiency; health; metabolic diseases; nutrition

(This special issue belongs to the Section Nutrition and Metabolism)

NMR-Based Metabolomics in Biomedicine and Food Science

edited by

Gaia Meoni

and

Alessia Vignoli

submission deadline 13 Feb 2026 | 3 articles | Viewed by 2167 | Submission Open

Keywords: metabolomics; NMR; biomedicine; food; fingerprinting; profiling; AI; ML

(This special issue belongs to the Section Metabolomic Profiling Technology)

Metabolism in Kidney Disease

edited by

Vincenzo Calabrese

Elisa Longhitano

and

Domenico Santoro

submission deadline 15 Feb 2026 | 2 articles | Viewed by 1897 | Submission Open

Keywords: biomarkers; CKD; dialysis; electrolytes; metabolism; inflammation; survey

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Effects of Nutrition and Exercise on Cardiometabolic Health

edited by

Sam Emerson

submission deadline 16 Feb 2026 | 1 articles | Viewed by 863 | Submission Open

Keywords: cardiovascular health; metabolic health; diet; nutrition; exercise; physical activity; body composition; obesity; metabolites; metabolism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Role of Lipid Metabolism in Cardiovascular Health

edited by Irma Magaly Rivas Serna and

Timothy O'Toole

submission deadline 16 Feb 2026 | Viewed by 252 | Submission Open

Keywords: metabolism of lipids; lipid classes; lipid species; cardiovascular health; lipidomics; cardiometabolic disease; cardiovascular disease; atherosclerosis; dyslipidemia; phospholipids; glyceride lipids; non-glyceride lipids; sphingolipids; ceramides; cardiac biomarkers; mechanism

(This special issue belongs to the Section Endocrinology and Clinical Metabolic Research)

Metabolomic Insights: Interplay Between Metabolism and Immune Response in Cancer

edited by

Dimitra Rafailia Bakaloudi

submission deadline 20 Feb 2026 | 1 articles | Viewed by 1091 | Submission Open

Keywords: metabolites; metabolism; cancer; immune response; immunotherapy; immunometabolism

(This special issue belongs to the Section Cell Metabolism)

Secondary Metabolites and Their Activities: From the Identification to the Biological Investigation

edited by Valeria Cavalloro and

Emanuela Martino

submission deadline 28 Feb 2026 | 5 articles | Viewed by 10805 | Submission Open

Keywords: active metabolites; green extraction; bioactivity; natural products; structural elucidation

(This special issue belongs to the Section Pharmacology and Drug Metabolism)

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