Special Issue "Early Programming: Crosstalk between Maternal Carbohydrate Diet and Metabolic Flexibility"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 141

Special Issue Editors

Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, 18071 Granada, Spain
Interests: signaling pathways, diabetes, metabolic flexibility, early programming, obesity, muscle differentiation
Special Issues, Collections and Topics in MDPI journals
Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Granada, 18071 Granada, Spain
Interests: metabolic flexibility, nutritional regulation of gene expression, metabolic engineering
Special Issues, Collections and Topics in MDPI journals
Abbott Nutrition R&D, Camino de Purchil 68, 18004 Granada, Spain
Interests: growth development, obesity, diabetes, sarcopenia–cachexia, bone metabolism, nutrition
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Dietary intervention has a direct influence not only on physiological functions but also on pathological situations, such as metabolic syndrome, diabetes, or cardiovascular diseases. There is evidence that adverse situations during early development have a direct impact on later periods of life. Environmental factors, including nutritional status, in the fetal and neonatal periods, are related to the risk of non-communicable diseases later on, such as metabolic syndrome. Therefore, one of the key points for dietary intervention is the control of glycemia during pregnancy, especially among obese women, since there is a well-established relationship between insulin resistance and adverse consequences for both mother and offspring. Nowadays, the advantage in the use of different mixtures of carbohydrates, in which rapid-digesting carbohydrates (saccharose) are replaced with low-glycemic-index (GI) carbohydrates is being explored as a rational approach.

Metabolic flexibility is the capability of a system to regulate fuel oxidation or storage (primarily glucose and fatty acids) in response to nutrient availability. Metabolic flexibility also relies on organ interplay, since the liver, adipose tissue, and muscle regulate energy homeostasis in a coordinated fashion, depending on the caloric intake and energy demand.

This Special Issue will focus on the importance of the quality, rather than the quantity, of carbohydrates during pregnancy to prevent an impact on disease risk in the offspring through the modulation of metabolic flexibility.

Specific areas to be addressed include the significance of early programming of metabolic flexibility in the offspring in different tissues and organs, preventing diseases, such as diabetes, obesity, cancer, inflammation, and non-alcoholic fatty acid liver disease.  Manuscripts dealing with other pertinent challenging issues are also highly desired.

Prof. Dr. Maria D. Giron-Gonzalez
Prof. Dr. Rafael Salto-Gonzalez
Dr. Jose M. López-Pedrosa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • early programming
  • insulin-resistant pregnancy
  • diabetes
  • obesity
  • metabolic flexibility
  • non-alcoholic fatty liver disease
  • slow-digesting carbohydrates
  • cancer
  • inflammation

Published Papers

There is no accepted submissions to this special issue at this moment.
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