Special Issue "Exploring Metabolites of Diabetes and Diabetic Complications: Current Perspectives and Future Directions"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 February 2023) | Viewed by 1488

Special Issue Editors

Metabolomics Research Facility, Duke-NUS Medical School, Singapore City, Singapore
Interests: metabolomics; stable isotope tracing; metabolic disease; mass spectrometry
Dr. Yingswan Ho
E-Mail Website
Guest Editor
A-Star, Bioprocessing Technology Institute, Singapore City, Singapore
Interests: metabolomics; omics

Special Issue Information

Dear Colleagues,

Diabetes had always been thought of as a disease which is mainly prevalent in high-income countries, but in fact, the rate of this disease is also rapidly growing among people from low- and middle-income countries. According to statistics published by the WHO, 1.5 million people died due to diabetes as a direct cause in 2019, and there was a 5% increase in premature mortality from diabetes between 2000 and 2016. Moreover, the COVID-19 pandemic made the situation for diabetic patients worse: patients with diabetes not only have a higher chance of serious complications from COVID-19 infections, but also, those with COVID-19 infections have increased risk of developing diabetes even with mild infections. Given the many issues presented by diabetes and its complications, such as diabetic retinopathy, nephropathy, neuropathy, cardiovascular disease, and stroke, this Special Issue will investigate current perspectives and future directions regarding how metabolites can help in the understanding and treatment of these diseases.

Dr. Jianhong Ching
Dr. Yingswan Ho
Guest Editors

Manuscript Submission Information

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Keywords

  • multi-omics
  • diabetes
  • obesity
  • insulin resistance
  • metabolites
  • biomarkers
  • diabetic complications
  • metabolic disease

Published Papers (1 paper)

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Research

Article
d-Amino Acids and Classical Neurotransmitters in Healthy and Type 2 Diabetes-Affected Human Pancreatic Islets of Langerhans
Metabolites 2022, 12(9), 799; https://doi.org/10.3390/metabo12090799 - 27 Aug 2022
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Abstract
The pancreatic islets of Langerhans are clusters of cells that function as endocrine units synthesizing and releasing insulin and a range of additional peptide hormones. The structural and chemical characteristics of islets change during type 2 diabetes development. Although a range of metabolites [...] Read more.
The pancreatic islets of Langerhans are clusters of cells that function as endocrine units synthesizing and releasing insulin and a range of additional peptide hormones. The structural and chemical characteristics of islets change during type 2 diabetes development. Although a range of metabolites including neurotransmitters has been reported in rodent islets, the involvement of these cell-to-cell signaling molecules within human pancreatic islets in the pathophysiology of type 2 diabetes is not well known, despite studies suggesting that these molecules impact intra- and inter-islet signaling pathways. We characterize the enigmatic cell-to-cell signaling molecules, d-serine (d-Ser) and d-aspartate (d-Asp), along with multiple classical neurotransmitters and related molecules, in healthy versus type 2 diabetes-affected human islets using capillary electrophoresis separations. Significantly reduced d-Ser percentage and gamma-aminobutyric acid (GABA) levels were found in type 2 diabetes-affected islets compared to healthy islets. In addition, the negative correlations of many of the signaling molecules, such as d-Ser percentage (r = −0.35), d-Asp (r = −0.32), serotonin (r = −0.42), and GABA (r = −0.39) levels, with hemoglobin A1c (HbA1c) levels and thus with the progression of type 2 diabetes further demonstrate the disruption in intra- or inter-islet signaling pathways and suggest that these cell-to-cell signaling molecules may be potential therapeutic targets. Full article
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