Special Issue "Advances in Lipid Research in Dry Eye Disease"

Dear Colleagues,

We are pleased to invite you to submit papers regarding this Special Issue about the importance of lipidomic approaches in dry eye disease (DED). The issue intends to deliver an overview of the current knowledge in this field and to open new windows in DED pathophysiology through innovative lipidomic approaches dedicated to improving the description of cellular mechanisms. Indeed, lipids are key mediators of biological processes, such as inflammation, oxidative stress, and apoptosis.

During the last decade, the definition of DED has been refined and enriched through robust scientific studies involving experimental research as well as clinical findings. Indeed, the revised definition supports increasing evidence in the dysregulation of tear film and ocular surface homeostasis, driven by tear hyperosmolarity, neurosensory abnormalities, and chronic inflammatory reactions. Thus, the pathology can be caused or sustained by auto-immune reactions, environmental stresses, surgical or medical interventions, allergens, and particularly pollutants, and finally leads to a self-stimulated vicious cycle. The decrease in the ocular surface protection causing cellular damages results in symptoms of discomfort, visual disturbance, and pain.

This Special Issue is devoted to shedding light and to deciphering the lipid species involvement in the cellular dysregulation as well as in tear film alteration, to optimizing and developing lipidomic analysis on tiny samples from ocular surface specimens, and to identifying lipidomic signatures or response profiles in DED.

Dr. Françoise Brignole-Baudouin
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• dry eye disease
• lipidomic
• biomarkers
• oxidative stress
• inflammation
• metabolism
• pathophysiology
• in vitro models
• animal models
• clinical research