Special Issue "Bile Acid Metabolism and Gut Microbiota Volume 2"

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Microbiology and Ecological Metabolomics".

Deadline for manuscript submissions: 15 April 2023 | Viewed by 114

Special Issue Editors

Helmholtz Zentrum für Umweltforschung, Department of Molecular Systems Biology, 15, 04318 Leipzig, Germany
Interests: metabolomics (targeted/untargeted); human biomonitoring; microbiom research; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Helmholtz Zentrum für Umweltforschung, 15, 04318 Leipzig, Germany
Interests: targeted and untargeted metabolomics; LC-MS/MS-based methodology development; biomarkers
Special Issues, Collections and Topics in MDPI journals
Helmholtz Zentrum für Umweltforschung, 15, 04318 Leipzig, Germany
Interests: intestinal microbiome; multi-omics; metabolomics (targeted/untargeted); metaproteomics; 16S rRNA gene sequencing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Bile acids, which have a primary function in nutrient absorption, are also heavily involved in gut–microbiota host signaling. Primary bile acids are synthesized in the liver by the host and are then conjugated before being released into the intestinal tract. In the intestinal tract, they can be reabsorbed and transported with the portal blood to the liver, forming the enterohepatic circulation. In the gut, conjugated primary bile acids can be deconjugated, followed by conversion to secondary bile acids by specific bacteria. The bile acids present in the gut influence the composition of the gut microbiota because of their differing bactericidal properties. In addition, secondary bile acids are reabsorbed in the colon and are known to act as signaling molecules in several host processes, including glucose homeostasis, immune system regulation and lipogenesis. Thus, bile acid and gut microbiota research is a compelling field with imperative health implications.

This Special Issue of Metabolites, “Bile Acids and Gut Microbiota”, will deal with the interactions between bile acids and the gut microbiota as well as the resulting host effects. This Special Issue seeks results from both basic research (cell or animal models) and epidemiological studies. In addition, new measurement methods, bioinformatical tools and data analysis concepts are welcome.

Dr. Ulrike E. Rolle-Kampczyk
Dr. Beatrice Engelmann
Dr. Sven-Bastiaan Haange
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bile acids
  • gut microbiota
  • host interactions
  • intestinal crosstalk
  • microbial regulation

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Published Papers

This special issue is now open for submission.
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