Special Issue "Physiological and Pathological Functions of Metabolite-Modified Proteins"

Dear Colleagues，

Cell metabolism owns a central position in physiological and pathological processes. It not only provides ATP and intermediate materials for cell growth and proliferation, but also some key metabolites, such as acetyl-CoA, lactate, α-KG, SAM, etc., which have found important roles in stem cell fate conversion and cancer cell genesis via epigenetic regulation. Post-translational modification of protein, including acetylation, lactylation, and methylation, has broad functions by participating in protein activity, subcellular location, interaction, chromatin assembly, etc. However, various challenges remain to be addressed, including the detection of new metabolites and post-translational modification, the writer and eraser of different modifications, biological pathway identification, etc. Therefore, this Special Issue aims to publish manuscripts on the functions of metabolite-modified proteins in physiological and pathological processes.

Prof. Dr. Shimin Zhao
Prof. Dr. Xingguo Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• metabolism
• metabolites
• protein modification
• epigenetic regulation
• pluripotency/cancer
• metabolic diseases

Tentative Title: LSD1 lactylation faciliates its demethylase activity to promote cancer progression
Author: Huafeng Zhang
Affiliation: School of Life Science, The University of Science and Technology of China, Hefei, China