Special Issue "Advances in Renal Replacement Therapy in Acute Kidney Injury"

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Nephrology".

Deadline for manuscript submissions: 10 February 2023 | Viewed by 901

Special Issue Editor

Prof. Dr. Michal Nowicki
E-Mail Website
Guest Editor
Department of Nephrology, Hypertension, and Kidney Transplantation, Medical University of Łódź, 90-145 Łódź, Łódzkie, Poland
Interests: kidney diseases (nephrology); solid organ transplantation; metabolic disorders; mineral and calcium metabolism; arterial hypertension—primary and secondary; systemic vasculitis; thrombotic microangiopathies and orphan (rare and ultrarare) diseases in adults
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Special Issue Information

Dear Colleagues,

Acute kidney injury (AKI) is an acute and potentially reversible worsening of kidney excretory function, and frequently leads to a need of intermittent or continuous renal replacement therapy. Although it may also develop in patients without preexisting significant comorbidities as a result of a variety of acute causes (e.g., severe dehydration, hypotension, toxins, drugs) AKI is most commonly a complication in critically ill patients. In these patients AKI is associated with very high morbidity and mortality. There has been a substantial change in the epidemiology of AKI in recent decades, and the incidence of AKI requiring renal replacement therapy (RRT) is increasing by approximately 10% per year. These changes are mostly due to the ageing of the population. RRT is initiated in a case of AKI to give time to restore kidney function, but also to combat hemodynamic instability and fluid and electrolyte disturbances. There is an ongoing debate over the optimal timing of initiation of RRT and the selection of its modality. The advances in dialysis techniques led to the introduction of several new modalities including continuous venovenous hemofiltration, continuous venovenous hemodialysis, continuous venovenous hemodiafiltration and intermittent hemodialysis or hemodiafiltration. The choice may be difficult even for an experienced nephrologist or intensivist, and universally accepted guidelines are lacking. Additionally, the choice of the serum and urine biomarkers that may predict the course and outcome of AKI and the need for the introduction of a particular method of RRT remains debatable and requires further research.

The aim of this Special Issue is to welcome researchers to submit original papers, review articles, or commentaries in the clinical and technological management in the field of nephrology. 

Prof. Dr. Michal Nowicki
Guest Editor

Manuscript Submission Information

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  • acute kidney injury
  • hemodialysis
  • hemodiafiltration
  • hemofiltration
  • continuous renal replacement therapy
  • biomarkers of acute kidney injury
  • critical care nephrology
  • hemodynamic instability
  • metabolic acidosis
  • electrolyte abnormalities
  • hyperkalemia
  • uremia
  • volume overload

Published Papers (1 paper)

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Decreased Monocyte HLA-DR Expression in Patients with Sepsis and Acute Kidney Injury
Medicina 2022, 58(9), 1198; https://doi.org/10.3390/medicina58091198 - 01 Sep 2022
Cited by 2 | Viewed by 797
Background and objectives: Acute kidney injury (AKI) is common in critically ill patients, especially those with sepsis. Persistently low human leukocyte antigen (HLA)-DR expression in monocytes reflects the decreased function of antigen-presenting cells, contributing to poor outcomes in sepsis. This study aimed to [...] Read more.
Background and objectives: Acute kidney injury (AKI) is common in critically ill patients, especially those with sepsis. Persistently low human leukocyte antigen (HLA)-DR expression in monocytes reflects the decreased function of antigen-presenting cells, contributing to poor outcomes in sepsis. This study aimed to establish an association between AKI and HLA-DR expression in monocytes of patients with sepsis. Materials and Methods: We detected HLA-DR expression in monocytes and measured plasma levels of S100A12, high-mobility group box 1 (HMGB1), advanced glycation end products (AGE), and soluble receptor for AGE (sRAGE) from septic patients and healthy controls. Results: HLA-DR expression in monocytes was decreased in patients with AKI than in those without AKI (29.8 ± 5.0% vs. 53.1 ± 5.8%, p = 0.005). Compared with AKI patients, the mean monocyte HLA-DR expression in patients with end-stage renal disease was increased without statistical significance. There were no differences in the AGE/sRAGE ratio and plasma levels of S100A12, HMGB1, AGE, and sRAGE between patients with and without AKI. Conclusions: Compared with septic patients without AKI, patients with AKI had significantly lower HLA-DR expression in monocytes. The role of hemodialysis in monocyte HLA-DR expression needs further studies to explore. Full article
(This article belongs to the Special Issue Advances in Renal Replacement Therapy in Acute Kidney Injury)
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