Special Issue "Prevention, Diagnosis and Treatment of Cervical Cancer"

Dear Colleagues,

Cervical cancer, caused by an invasive tumor that affects 500,000 women globally each year, is associated with the human papillomavirus (HPV). About 80% of cervical cancer cases occur among women in developing countries. Intriguingly, HPV can cause a pre-invasive lesion, allowing for both primary (vaccines) and secondary (papanicolaou, DNA HPV test) prevention measures to be taken. Screening strategies, triage for colposcopy, and the histopathological diagnosis of lesions are constantly changing. In contrast, in the diagnosis of cervical lesions, adjuvant tests such as immunohistochemistry are eventually required, which identify tumor markers to determine the lesion with the highest evolutionary risk. A tumor can be treated via surgery or radiotherapy, depending on its stage.

This special issue of Medicina intends to assemble research that addresses the prevention, diagnosis, and treatment of cervical cancer. Research in this area has evolved significantly thanks to improvements in our understanding of the association between the vaginal microbiome and metabolome; the applicability of fewer doses of prophylactic vaccines; the use of therapeutic vaccines; factors associated with the prognosis of the disease; and the increase in the number of studies on strategies for organized screening programs in under-resourced countries. Innovative research can usher in new therapeutic horizons in metabolome and vaccine therapy.

Dr. José Eleutério
Prof. Dr. Ana Katherine Da Silveira Gonçalves
Guest Editors

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• uterine cervical neoplasms
• papillomavirus infections
• papillomavirus vaccines
• papanicolaou test
• human papillomavirus DNA tests
• colposcopy