Special Issue "Polymeric Nanoparticles for siRNA Delivery"
A special issue of Materials (ISSN 1996-1944).
Deadline for manuscript submissions: 30 April 2020.
Interests: Pyrrole macrocycles for imaging and theranostics; Nanoparticles for sensing applications and drug delivery
Special Issues and Collections in MDPI journals
Small interfering RNA (siRNA) has many potential applications in biomedicine for the treatment of several deceases such as genetic disorders and cancer. However, because of the inherent instability of siRNA in the bloodstream the use of efficient carriers is required. In this context, cationic polymers have been proposed in order to protect the RNA by means of the formation of nanoscopic complexes, which result from the interaction of these polymers and the negatively charged siRNA strands. The versatility of such nanoparticles is due to their straightforward preparation, the facile synthetic access to the polymers, and the easy decoration of their backbone with a wide variety of biomolecules. Examples of the later are the conjugation of the nanoparticles with small-molecule ligands and antibodies in order to introduce selectivity in the targeting or peptides to improve their cellular uptake. However, although the use of such particles is promising, still many challenges must be addressed in order to bring the benefits of this technology from the lab to the clinic.
This Special Issue is open to new advances in the application of polymeric nanoparticles for siRNA delivery, involving the following:
- Design and preparation of the polymers;
- Decoration of the polymers using bio-conjugation technics;
- Assessment of the stability, biocompatibility, and safety of particles;
- Study of the effective delivery of siRNA in vitro and in vivo.
Dr. David Sánchez-García
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Polymeric nanoparticles
- siRNA delivery
- Targeted delivery
- Gene delivery.