Special Issue "Current Concepts in Tissue Fibrosis—Common and Distinct Pathways"
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 17 September 2021.
Special Issue Editors
Interests: fibrosis; ECM remodeling; immunology; cytokine; reproduction; endometrium; endometrial disorders
Interests: reproduction; mare; corpus luteum; oviduct; endometrium; endometrosis; endocrinology; cytokines; fibrosis; epigenetics
Special Issues and Collections in MDPI journals
Interests: reproduction; implantation; immunology; proteomics; endometrial remodeling; embryo development
Special Issue Information
Dear Colleagues,
Around 45% of total human deaths, worldwide, are caused by fibrotic diseases. Over-production of extracellular matrix components is a commonly observed hallmark of fibrotic diseases and ultimately results in a severely scarred, rigid, and functionally impaired organ. Chronic fibrosis affects multiple organ systems including the heart, lung, kidney, liver, skin, and uterus. Although, fibrosis is a well-recognized cause of morbidity and mortality, current therapies for fibrosis are scarce and of limited efficacy. The medical need for effective antifibrotic therapies is, thus, remarkably high. Therefore, there is an urgent need to understand the pathogenesis of fibrosis, considering its onset, putative regression, or mostly its chronic and permanent establishment. This knowledge will surely contribute to the identification of potential therapeutic approaches. A feasible strategy to treat fibrosis is to target common mechanisms and core pathways that are of central pathophysiological relevance across different fibrotic diseases. The underlying molecular and cellular events of fibrotic diseases share many functional similarities, despite differences in etiology and clinical outcome. Studies conducted on fibrosis use cell-culture systems, and in vivo model systems. Since ethical and methodological approaches restrain the study of fibrosis in humans, animal models provide good alternatives. Spontaneous fibrosis occurs in animal species, including dogs, horses, donkeys, and cats. Thus, owing to shared mechanisms of fibrosis in many diseases, research performed on animals could be translated to humans. We would like to invite all investigators working on fibrosis using in vitro and in vivo methods in human and animal species to share their knowledge about fibrosis biology with the scientific community in this Special Issue.
Dr. Anna Szóstek-MioduchowskaDr. Graça Ferreira-Dias
Dr. Beenu Moza Jalali
Dr. Joanna Bukowska
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.
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Keywords
- fibrosis
- tissue remodeling
- animal models
- immune cells
- inflammation
- extracellular matrix
- markers of fibrosis
- uncontrolled wound healing
- organ dysfunction
Planned Papers
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Author: Dr. Anna Szóstek-Mioduchowska
Affiliation: Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
Author: Dr. Joanna Bukowska
Affiliation: Institute of Animal Reproduction and Food Research, Polish Academy of Sciences
Author: Dr. Isabel Faust
Affiliation: University Clinic of the Ruhr University Bochum
Author: Dr. Francesco Del Gald
Affiliation: University of Leeds
Author: Dr. Jung Eun Kim
Affiliation: The Catholic University of Korea
Author: Dr. Francesco Salton
Affiliation: University Hospital of Trieste
Author: Dr. Masamitsu Ichihashi
Affiliation: Department of Dermatology and Internal Medicine, Shinbashi, Japan