Special Issue "Origin of Eukaryotes"

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Origin of Life".

Deadline for manuscript submissions: 25 February 2022.

Special Issue Editors

Prof. Dr. David A. Baum
E-Mail Website
Guest Editor
Department of Botany and Wisconsin Institute for Discovery, University of Wisconsin Madison, Madison, WI 53706-1381, USA
Interests: evolutionary and phylogenetic theory; plant evolution; origin of life
Special Issues, Collections and Topics in MDPI journals
Dr. Gautam Dey
E-Mail Website
Guest Editor
European Molecular Biology Laboratory, 22607 Hamburg, Germany
Interests: systems biology; cell Biology; evolutionary biology; cytoskeleton; polarity and cell shape; nucleus; nuclear remodeling; cell division

Special Issue Information

Dear Colleagues,

The origin of eukaryotes was one of the most important transitions during the evolution of life on Earth. Historically, this transition has been hard to elucidate because of the large numbers of differences between eukaryotes and prokaryotes and the consequent difficulty in determining the order in which different features arose. While multiple competing theories exist, these have been difficult to resolve because of the wide gap between the last eukaryotic common ancestor (“LECA”) and the last ancestor shared by eukaryotes and an extant prokaryotic group. The last five years have seen the discovery of a new lineage of Archaea, the Asgard Archaea, which are significantly more closely related to eukaryotes than any previously known prokaryotic group. Combined with improvements in our understanding of eukaryotic diversity, advances in both archaeal and eukaryotic cell biology, and new phylogenomic methods for reducing phylogenetic artifacts when studying ancient events, it is becoming increasing possible to evaluate competing theories to explain the ecological, biochemical, and structural changes during the origin of eukaryotes.

We would hereby like to take this opportunity to invite you to submit original research articles in the form of theoretical/conceptual papers, reviews, and new empirical results that shed light on this remarkable and consequential evolutionary transition.

We very much look forward to receiving your contributions.

Prof. Dr. David A. Baum
Dr. Gautam Dey
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • eukaryotes
  • archaea
  • Loki
  • cell biology
  • phylogenomics
  • metagenomics
  • endosymbiosis
  • mitochondria
  • nuclei
  • endomembrane system

Published Papers

This special issue is now open for submission.
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