Harnessing Mitochondrial Rewiring for Cancer Therapy: Novel Strategies in the Era of Precision Medicine
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Physiology and Pathology".
Deadline for manuscript submissions: 26 June 2026
Special Issue Editor
Interests: genome integrity; epigenetic regulation; gene expression; translation; viruses; molecular virology; viruses’ evolution
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The historical paradigm of cancer metabolism, long dominated by the Warburg effect’s emphasis on aerobic glycolysis, has undergone a fundamental transformation. We now recognize that mitochondria are not merely dysfunctional bystanders but are dynamic, biosynthetic, and signaling hubs that actively drive tumorigenesis, metastasis, and therapeutic resistance. This Special Issue, “Harnessing Mitochondrial Rewiring for Cancer Therapy: Novel Strategies in the Era of Precision Medicine”, aims to crystallize the rapid advancements in our understanding of mitochondrial plasticity. It addresses the critical need to decipher how cancer cells reprogram mitochondrial networks to survive distinct microenvironmental stresses, including hypoxia, nutrient deprivation, and immune surveillance. The scope of this Special Issue encompasses the full spectrum of mitochondrial biology in oncology: from the dysregulation of the electron transport chain and the accumulation of oncometabolites like 2-hydroxyglutarate and succinate to the macroscopic dynamics of fission and fusion that propel metastatic invasion. We invite authors to submit original research and comprehensive reviews that illuminate these mechanisms and propose innovative strategies to dismantle the mitochondrial engine of malignancy, and particularly welcome contributions that bridge the gap between their basic biology and clinical application.
Dr. Theodoros Rampias
Guest Editor
Manuscript Submission Information
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Keywords
- mitochondria
- reprogram
- cancer therapy
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