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Life
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Advanced Bio-Imaging and Microscopy for Application in Molecular and Cell...
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Special Issue "Advanced Bio-Imaging and Microscopy for Application in Molecular and Cell Biology"

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Biochemistry, Biophysics and Computational Biology".

Deadline for manuscript submissions: closed (23 December 2022) | Viewed by 1144

Special Issue Editors

Dr. Jeong Min Chung
E-Mail Website
SciProfiles
Guest Editor
Department of Biotechnology, The Catholic University of Korea, Bucheon-si 14662, Gyeonggi, Korea
Interests: cryo-electron microscopy; bacterial secretion system; membrane proteins; structural biology; biochemistry; pathogens; bio-imaging
Dr. Bumhan Ryu
E-Mail
SciProfiles
Guest Editor
Research Solution Center, Institute for Basic Science, Daejeon 34126, Korea
Interests: cryo-EM; transmission electron microscopy; image processing; protein structure
Dr. Jaekyung Hyun
E-Mail Website
SciProfiles
Guest Editor
Department of Convergence Medicine, Pusan National University School of Medicine, 49 Busandaehak-ro, Mulgeum-eup, Yangsan-si 50612, Gyeongsannam-do, Korea
Interests: cryo-EM; transmission electron microscopy; image processing; protein structure; virology

Special Issue Information

Dear Colleagues,

We recently set up a Special Issue aimed at gathering the latest advances and outstanding research in the field of bio-imaging and analytical microscopic techniques in molecular and cell biology. We would like to invite research publications and review articles on, but not limited to, the following topics:

  • The three-dimensional structural analysis of protein complexes;
  • Cryo-electron microscopy in drug discovery;
  • Molecular dynamics study of macromolecular machinery using bio-imaging;
  • Artificial intelligence or deep learning in bio-imaging.

Dr. Jeong Min Chung
Dr. Bumhan Ryu
Dr. Jaekyung Hyun
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • 3D structure of protein complex
  • cryo-electron microscopy
  • image processing
  • artificial intelligence
  • deep learning
  • molecular dynamics
  • macromolecular nanomachines

Published Papers (1 paper)

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Review

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Review
Artificial Intelligence in Cryo-Electron Microscopy
by
Jeong Min Chung
,
Clarissa L. Durie
and
Jinseok Lee
Life 2022, 12(8), 1267; https://doi.org/10.3390/life12081267 - 19 Aug 2022
Viewed by 911
Abstract
Cryo-electron microscopy (cryo-EM) has become an unrivaled tool for determining the structure of macromolecular complexes. The biological function of macromolecular complexes is inextricably tied to the flexibility of these complexes. Single particle cryo-EM can reveal the conformational heterogeneity of a biochemically pure sample, [...] Read more.
Cryo-electron microscopy (cryo-EM) has become an unrivaled tool for determining the structure of macromolecular complexes. The biological function of macromolecular complexes is inextricably tied to the flexibility of these complexes. Single particle cryo-EM can reveal the conformational heterogeneity of a biochemically pure sample, leading to well-founded mechanistic hypotheses about the roles these complexes play in biology. However, the processing of increasingly large, complex datasets using traditional data processing strategies is exceedingly expensive in both user time and computational resources. Current innovations in data processing capitalize on artificial intelligence (AI) to improve the efficiency of data analysis and validation. Here, we review new tools that use AI to automate the data analysis steps of particle picking, 3D map reconstruction, and local resolution determination. We discuss how the application of AI moves the field forward, and what obstacles remain. We also introduce potential future applications of AI to use cryo-EM in understanding protein communities in cells. Full article
(This article belongs to the Special Issue Advanced Bio-Imaging and Microscopy for Application in Molecular and Cell Biology)
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