Special Issue "The Biological Value of Carbohydrates – from Synthesis to Detection"
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Biochemistry, Biophysics and Computational Biology".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 135
Interests: insulin-like growth factors peptides/binding proteins/receptors; metabolism; metabolic disorders; diabetes; protein purification; post-translational modifications
A vast portion of secreted proteins is scarcely to heavily decorated with various forms of carbohydrates neatly organized and strategically positioned. Proteins can be glycosylated even if they are not secreted and similar to gate-keepers, glycans can encourage or prevent some interactions. All in all, they can dictate interactions between different macromolecules as they are involved in host-pathogen interaction, cell–cell interaction, cell adhesion, implementation and other numerous biological activities. and it is noted that life habits, sex, age, as well as different physiological and pathological conditions can affect glycosylation pattern of protein, cell or tissue. Glycosylation is not exclusive to proteins as carbohydrates can be enzymatically added also to other types of macromolecules. It is already widely known that glycosylation per se is not genetically encoded. Still, there is genetic information on different enzymes and proteins involved in glycosylation processes, making the field of glycans investigation (i.e., glycomics) more complex and strenuous.
Due to the enormous biological importance of glycans, this issue aims to provide an overview of molecular mechanisms of N- and O- glycosylation, detection of glycans, their deciphering, distribution and alterations in different processes. We encourage the submission of review articles and original papers. Research articles on non-enzymatic glycosylation and advanced glycation end-products are also welcome.
Dr. Olgica Nedic
Dr. Dragana Robajac
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