Special Issue Information

Dear Colleagues,

We are proud to serve as Guest Editors for this Special Issue of JPM entitled “Progress in Pathogenesis, Diagnosis and Treatment of Cardiac Arrhythmia in Cardiomyopathies”. Cardiomyopathies constitute a leading cause of mortality and morbidity, frequently occurring in young patients. In particular, ventricular arrhythmias are responsible for sudden cardiac death and may complicate a number of genetic and acquired myocardial diseases, including, but not limited to, hypertrophic, dilated, arrhythmogenic and inflammatory cardiomyopathies. In this setting, atrial tachyarrhythmias and conduction system disease may constitute an additional issue. In recent years, a significant improvement in diagnostic techniques has occurred, allowing an earlier detection of both cardiomyopathy signs and arrhythmic events. Innovative and dedicated tools are currently available for arrhythmic risk stratification. Currently, patient-tailored treatment strategies range from conservative pharmacological regimens to interventional approaches, encompassing cardiac device implants and catheter ablation of arrhythmia. Last but not least, preclinical studies have shown plenty of novel arrhythmogenic mechanisms involving specific genetic and acquired cardiomyopathies, allowing the identification of new promising targets for molecular treatment.

In light of the above, we are confident that many brilliant scientists involved in this emerging research field will valuably contribute to this Special Issue.

Dr. Giovanni Peretto
Dr. Patrizio Mazzone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

myocarditis
cardiomyopathy
nonischemic
arrhythmias
sudden cardiac death
ablation

Published Papers (2 papers)

Download All Papers

Editorial

Jump to: Research

Open AccessEditorial

Arrhythmogenic Cardiomyopathy: One, None and a Hundred Thousand Diseases

Giovanni Peretto

and

Patrizio Mazzone

J. Pers. Med. 2022, 12(8), 1256; https://doi.org/10.3390/jpm12081256 - 30 Jul 2022

Viewed by 835

Abstract

According to the most recent expert consensus statement, arrhythmogenic cardiomyopathy (AC) is defined as an arrhythmogenic heart muscle disorder, not explained by ischemic, hypertensive, or valvular heart disease, presenting clinically as symptoms or documentation of atrial fibrillation, conduction disease, and/or right ventricular (RV) [...] Read more.

(This article belongs to the Special Issue Progress in Pathogenesis, Diagnosis and Treatment of Cardiac Arrhythmia in Cardiomyopathies)

Research

Jump to: Editorial

Open AccessArticle

Exercise Stress Test Late after Arrhythmic versus Nonarrhythmic Presentation of Myocarditis

and

J. Pers. Med. 2022, 12(10), 1702; https://doi.org/10.3390/jpm12101702 - 12 Oct 2022

Viewed by 781

Abstract

Background. Exercise stress test (EST) has been scarcely investigated in patients with arrhythmic myocarditis. Objectives. To report the results of EST late after myocarditis with arrhythmic vs. nonarrhythmic presentation. Methods. We enrolled consecutive adult patients with EST performed at least six months after acute myocarditis was diagnosed using gold-standard techniques. Patients with ventricular arrhythmia (VA) at presentation were compared with the nonarrhythmic group. Adverse events occurring during follow-up after EST included cardiac death, disease-related rehospitalization, malignant VA, and proven active myocarditis. Results. The study cohort was composed of 128 patients (age 41 ± 9 y, 70% males) undergoing EST after myocarditis. Of them, 64 (50%) had arrhythmic presentation. EST was performed after 15 ± 4 months from initial diagnosis, and was conducted on betablockers in 75 cases (59%). During EST, VA were more common in the arrhythmic group (43 vs. 4, p < 0.001), whereas signs and symptoms of ischemia were more prevalent in the nonarrhythmic one (6 vs. 1, p = 0.115). By 58-month mean follow-up, 52 patients (41%) experienced adverse events, with a greater prevalence among arrhythmic patients (39 vs. 13, p < 0.001). As documented both in the arrhythmic and nonarrhythmic subgroups, patients had greater prevalence of adverse events following a positive EST (40/54 vs. 12/74 with negative EST, p < 0.001). Electrocardiographic features of VA during EST correlated with the subsequent inflammatory restaging of myocarditis. Nonarrhythmic patients with uneventful EST both on- and off-treatment were free from subsequent adverse events. Conclusions. Late after the arrhythmic presentation of myocarditis, EST was frequently associated with recurrent VA. In both arrhythmic and nonarrhythmic myocarditis, EST abnormalities correlated with subsequent adverse outcomes. Full article

(This article belongs to the Special Issue Progress in Pathogenesis, Diagnosis and Treatment of Cardiac Arrhythmia in Cardiomyopathies)

► Show Figures