Special Issue "Transcriptional Control in Candida"
Deadline for manuscript submissions: 30 April 2022.
This Special Issue in the Journal of Fungi will explore the complex world of transcriptional regulation within the opportunistic human fungal pathogens of the Candida clade. This clade is host to several fungal pathogens of humans, including C. albicans, C. glabrata, C. parapsilosis, C. tropicalis, C. krusei, and C. auris, which are the predominant causes of nosocomial fungal infections. Although typically found as commensal members of the human microbiota, these fungi can transition to a pathogenic growth state, resulting in invasive or disseminated candidiasis with associated mortality rates exceeding 40%. While there are many unique differences between these species, they all share the ability to adapt to a wide range of environmental niches upon and within mammalian hosts, and they can transition between commensal and pathogenic states in response to complex environmental cues. Furthermore, many of these species can form two or more distinct morphologies and/or form tightly knit microbial communities known as biofilms. Several of these species also undergo a form of phenotypic differentiation that can be heritably maintained through hundreds or even thousands of cell divisions via epigenetic mechanisms. This phenotypic and morphological plasticity, and the ability to differentiate into distinct “developmental” programs, is controlled by complex, and often highly intertwined, transcriptional regulatory networks. In fact, some of the transcriptional networks that have been characterized in C. albicans bear striking similarities to the networks that control cellular differentiation in mammals. Thus, C. albicans has emerged as a powerful and compelling model system not only for investigating the transcriptional regulatory systems that control these fascinating aspects of Candida biology, but also as a potential model system for understanding more complex transcriptional networks in higher eukaryotes.
This Special Issue will feature a collection of original research articles and brief research reports, in addition to reviews, mini-reviews, methods, and opinion or perspective articles, that contribute to our understanding of transcriptional regulation within the opportunistic human fungal pathogens of the Candida clade. Contributions that focus on any aspect of Candida transcription, ranging from the molecular through organismal, population, or evolutionary level, are welcome. Studies that incorporate integrative or comparative approaches to expand our understanding of the highly interwoven, yet functionally distinct, transcriptional regulatory networks that control key phenotypic, morphological, or “developmental” programs within the Candida clade are of particular interest.
Dr. Aaron D. Hernday
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Fungi is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- transcriptional regulation
- host–fungal interactions
- functional genomics