Recent Advances in Yeast Lipid Production

A special issue of Journal of Fungi (ISSN 2309-608X). This special issue belongs to the section "Fungal Cell Biology, Metabolism and Physiology".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 695

Special Issue Editor


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Guest Editor
School of Bioengineering, Dalian University of Technology, Dalian, China
Interests: biofuels; biomass conversion; energy metabolism; metabolic engineering; microbial lipids; non-natural cofactors; process engineering; systems biology; synthetic biology

Special Issue Information

Dear Colleagues,

Lipids produced by yeasts are valuable resources as alternatives to those traditionally based on oil crops or plants. There is ever-growing interest in the production of yeast lipids via the use of renewable materials as carbon sources. In this Special Issue, contributions related to all aspects of yeast lipids are welcome. Submissions may deal with, but are not limited to, topics such as the genetics of oleaginous yeasts, systems biology of lipid accumulation, metabolic engineering for functional lipids or enhanced production capacity, process engineering for microbial lipid production, and the chemical or biological transformation of yeast lipids. This Special Issue is expected to cover the most recent developments in this area, promote further efforts in microbial lipid research, and, eventually, bring more yeast lipid products onto the market.

Prof. Dr. Zongbao Zhao
Guest Editor

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Keywords

  • biodiesel
  • functional lipids
  • lipid production process
  • lipidomics
  • metabolic engineering
  • oleochemicals
  • systems biology
  • sustainable aviation fuels
  • yeast lipids

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Published Papers (1 paper)

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Research

16 pages, 4025 KiB  
Article
The Plasma Membrane H+-ATPase Promoter Driving the Expression of FADX Enables Highly Efficient Production of Punicic Acid in Rhodotorula toruloides Cultivated on Glucose and Crude Glycerol
by Daniela Krajciova and Roman Holic
J. Fungi 2024, 10(9), 649; https://doi.org/10.3390/jof10090649 - 13 Sep 2024
Abstract
Punicic acid (PuA) is a conjugated fatty acid with a wide range of nutraceutical properties naturally present in pomegranate seed oil. To meet the rising demand for pomegranate seed oil, a single-cell oil enriched in PuA provides a sustainable biomass-derived alternative. This study [...] Read more.
Punicic acid (PuA) is a conjugated fatty acid with a wide range of nutraceutical properties naturally present in pomegranate seed oil. To meet the rising demand for pomegranate seed oil, a single-cell oil enriched in PuA provides a sustainable biomass-derived alternative. This study describes the production of a PuA-enriched single-cell oil through the engineering of the red yeast Rhodotorula toruloides grown in glucose and a low-cost substrate, crude glycerol. The gene for Punica granatum fatty acid conjugase, PgFADX, was randomly integrated into the genome of R. toruloides without disrupting the carotenoid synthesis. In shake flask studies, the effects of three promoters (PPGI1, PNAR1, and PPMA1) on PuA production were evaluated. PuA titers of 105.77 mg/L and 72.81 mg/L were obtained from engineered cells expressing PgFADX from the PPMA1 promoter cultivated for 72 h in glucose and for 168 h in crude glycerol, respectively. Furthermore, the detailed lipid analysis revealed a high enrichment PuA in the triacylglycerol lipid structures, even without substantial modifications to the metabolic pathways. This report demonstrates the high potential of R. toruloides in the upcycling of a low-cost substrate, crude glycerol, into a value-added product such as PuA. The findings support the feasibility of using engineered R. toruloides for sustainable production of PuA-enriched single-cell oil. Full article
(This article belongs to the Special Issue Recent Advances in Yeast Lipid Production)
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