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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Arthroplasty: Advances in Surgical Techniques and Patient Outcomes—2nd Edition

edited by Senthil Sambandam

submission deadline 15 Dec 2025 | 2 articles | Viewed by 2223 | Submission Open

Keywords: hip arthroplasty; knee arthroplasty; hip fractures; arthroplasty; osteoarthritis; knee arthroscopy; joint replacement

(This special issue belongs to the Section Orthopedics)

Cataract and Refractive Surgery and Intraocular Lens Implantation: Clinical Advances and Perspectives

edited by Janusz Skrzypecki

submission deadline 15 Dec 2025 | 1 articles | Viewed by 2010 | Submission Open

Keywords: cataract surgery; intraocular lens power calculation; intraocular lenses; EDoF IOL; multifocal IOL; monofocal IOL; laser refractive surgery

(This special issue belongs to the Section Ophthalmology)

Key Advances in the Treatment of the Critically Ill: 3rd Edition

edited by

Spyros D. Mentzelopoulos

submission deadline 15 Dec 2025 | 2 articles | Viewed by 1769 | Submission Open

Keywords: respiration; artificial ventilation; prone positioning; respiratory distress syndrome; respiratory insufficiency; cardiac arrest; induced hypothermia; amiodarone; vasopressin; steroids; epinephrine; trauma; injuries; tranexamic acid; sepsis; antibiotics; extracorporeal membrane oxygenation; extracorporeal CPR; blood purification

(This special issue belongs to the Section Intensive Care)

Cardiac Electrophysiology: Clinical Advances and Practice Updates—2nd Edition

edited by

Ibrahim Marai

submission deadline 15 Dec 2025 | 2 articles | Viewed by 1748 | Submission Open

Keywords: cardiac arrhythmias; cardiac implantable electronic device; catheter ablation; sudden cardiac death; lead extraction; atrial fibrillation; ventricular tachycardia; defibrillator therapy

(This special issue belongs to the Section Cardiology)

Clinical Advancements in Intraocular Lens Power Calculation Methods

edited by

Christoph Martin Lwowski

and Thomas Kohnen

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1489 | Submission Open

Keywords: emmetropia; IOL power calculation; effective lens position; refractive lens exchange; IOL; refractive surgery; biometry

(This special issue belongs to the Section Ophthalmology)

Rheumatoid Arthritis: Challenges, Innovations and Outcomes

edited by

Marco Fornaro

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1384 | Submission Open

Keywords: rheumatoid arthritis; pathogenesis; treatments; outcomes; autoimmunity

(This special issue belongs to the Section Immunology & Rheumatology)

Emergency Surgery: Clinical Updates and New Perspectives

edited by

Bruno Cirillo

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1287 | Submission Open

Keywords: emergency surgery; trauma surgery; acute abdomen; hernia emergencies; surgical decision making; perioperative care; damage control surgery; emergency management; critical care surgery; multidisciplinary approach

(This special issue belongs to the Section Emergency Medicine)

Latest Advances in Pediatric Surgery

edited by Francesco Macchini and Andrea Zanini

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1259 | Submission Open

Keywords: pediatric surgery; innovations; fluorescence-guided surgery; pediatric robotic surgery; minimally invasive surgery

(This special issue belongs to the Section General Surgery)

Cancers of the Pelvic Organs: Contemporary Management and Actions for Improving Patients’ Quality of Life: 2nd Edition

edited by

Agnieszka Mazur-Bialy

and

Marcin Opławski

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1252 | Submission Open

Keywords: gynecological cancers; e.g.; endometrial; cervical; ovarian; and vulvar cancer; urogenital tract cancers in men; e.g.; bladder; prostate; penis; and testicular cancer; gastrointestinal cancers; complications of oncological treatment; e.g.; pelvic floor disfunction: incontinence and POP; patients’ quality of life and possibilities of its improvement; oncofertility; physiotherapy; oncology treatment (modern surgical approach; including robotics; chemotherapy; radiotherapy; immunotherapy; targeted therapy); biological basis of pathogenesis and cancer progression; biological markers; anticancer agents; cancer prophylaxis and prevention— current trends and opportunities

(This special issue belongs to the Section Oncology)

New Frontiers in Therapeutic Drug Monitoring of Biologics in Inflammatory Bowel Disease and Other Immune-Mediated Inflammatory Diseases: 2nd Edition

edited by

Konstantinos Papamichael

submission deadline 15 Dec 2025 | 3 articles | Viewed by 1171 | Submission Open

Keywords: therapeutic drug monitoring; inflammatory bowel diseases; immune mediated inflammatory diseases; pharmacokinetics; anti-TNF; vedolizumab; ustekinumab; risankizumab; point-of-care assays; model informed precision dosing

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Gender Differences and Diversity in the Treatment of Gastric Cancer and Other Malignancies

edited by Claus Schildberg and Frank Meyer

submission deadline 15 Dec 2025 | 2 articles | Viewed by 1027 | Submission Open

Keywords: gastric cancer; other cancers; other treatment; gender differences; diversity; new challances

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Cardio-Rheumatology

edited by

Sophie I. Mavrogeni

submission deadline 15 Dec 2025 | 1 articles | Viewed by 1013 | Submission Open

Keywords: cardio-rheumatology; autoimmune diseases; cardiac imaging; cardiovascular disease; autoimmune rheumatic diseases

(This special issue belongs to the Section Cardiology)

Clinical Prediction, Diagnosis, and Treatment of Ovarian Cancer and Other Gynecologic Tumors

edited by Eleni T. Timotheadou and Emmanouil Saloustros

submission deadline 15 Dec 2025 | 1 articles | Viewed by 952 | Submission Open

Keywords: ovarian; endometrial; cervical; chemotherapy; immunotherapy; primary debulking surgery; interval debulking; fertility-sparing surgery; PARP inhibitors; radiotherapy; HIPEC; sex cord tumors; dysgerminoma; leiomyosarcoma; liquid biopsies; circulating tumor cells; ctDNA

(This special issue belongs to the Section Obstetrics & Gynecology)

New Clinical Advances in Pediatric Asthma

edited by

Davor Plavec

submission deadline 15 Dec 2025 | 1 articles | Viewed by 691 | Submission Open

Keywords: pediatric asthma; clinical management; treatment advances; diagnostic advances; biologic therapy; inhaled steroids; control of asthma; exacerbation prevention; quality of life

(This special issue belongs to the Section Clinical Pediatrics)

Thoracic Surgery: Current Practice and Future Directions: 2nd Edition

edited by

Dania Nachira

submission deadline 15 Dec 2025 | 1 articles | Viewed by 523 | Submission Open

Keywords: NSCLC; mediastinum; thymoma; esophageal disease; immunotherapy; new technologies; minimally invasive surgery; VATS; RATS

(This special issue belongs to the Section Respiratory Medicine)

Clinical Updates on Valvular Heart Diseases: A New Era in Personalized Treatment

edited by Massimiliano Mariani

submission deadline 15 Dec 2025 | 1 articles | Viewed by 482 | Submission Open

Keywords: valvular heart disease; structural heart intervention; imaging in valve disease; interventional echocardiography; minimally invasive cardiac surgery; aortic valve intervention; tricuspid valve intervention; valve intervention in GUCH; patient-specific therapy; advanced diagnostic techniques; gutting-edge cardiac imaging; catheter-based interventions; innovative cardiac therapies

(This special issue belongs to the Section Cardiology)

Blood Cancer: Current Status and Future Challenges in Acute Myeloid Leukemia (AML)

edited by

Salvatore Perrone

and Massimo Breccia

submission deadline 15 Dec 2025 | Viewed by 433 | Submission Open

Keywords: acute myeloid leukemia; hematology; leukemia; venetoclax; blood disorders

(This special issue belongs to the Section Hematology)

Clinical Advances in Cancer Imaging

edited by

Paul-Andrei Ștefan

submission deadline 15 Dec 2025 | Viewed by 165 | Submission Open

Keywords: pelvic oncology; cancer imaging; CT; MRI; tumor staging; treatment response; morphological criteria; gynecologic cancer; bladder cancer; rectal cancer; artificial intelligence; radiomics; texture analysis; image biomarkers; clinical imaging

(This special issue belongs to the Section Oncology)

Novel Prognostic Risk Factors in Acute Coronary Syndrome

edited by

Nicola Cosentino

and

Andrea Baggiano

submission deadline 15 Dec 2025 | Viewed by 118 | Submission Open

Keywords: acute coronary syndrome; risk stratification; biomarkers; cardiovascular imaging; inflammation; genetics; heart– kidney interaction; cardio-pulmonary complications; neurological dysfunction; precision medicine

(This special issue belongs to the Section Cardiology)

Advances in Diagnostic and Surgical Treatment in Lung Cancer and Related Pulmonary Disorders

edited by Natalia Motas and Veronica Manolache

submission deadline 17 Dec 2025 | 1 articles | Viewed by 1138 | Submission Open

Keywords: lung cancer; minimally invasive thoracic surgery (MITS); video-assisted thoracoscopic surgery (VATS); robot-assisted thoracic surgery (RATS); interventional pneumology; bronchoscopy; endobronchial ultrasound (EBUS); artificial intelligence (AI); lung nodule

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Transcatheter Aortic Valve Replacement: Second Edition

edited by

Anna Olasińska-Wiśniewska

and Maciej Dąbrowski

submission deadline 18 Dec 2025 | 2 articles | Viewed by 1147 | Submission Open

Keywords: aortic stenosis; transcatheter; bioprosthesis; TAVI; transcatheter aortic valve replacement

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical and Surgical Insights on Lung Cancer Treatment

edited by

Eleonora Faccioli

and Marco Schiavon

submission deadline 18 Dec 2025 | 1 articles | Viewed by 1107 | Submission Open

Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; clinical trials; robotic surgery; diagnosis; multimodal treatment; outcomes; targeted therapy

(This special issue belongs to the Section Respiratory Medicine)

Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation

edited by

Francisco J. Povedano-Montero

submission deadline 19 Dec 2025 | 3 articles | Viewed by 2285 | Submission Open

Keywords: retinal diseases; macular degeneration; maculopathies; diabetic retinopathy; retinal vascular occlusions; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

An Update on Retinal Diseases: From Diagnosis to Treatment

edited by

Shigeru Honda

, Masahiko Sugimoto and Kenji Yamashiro

submission deadline 20 Dec 2025 | 15 articles | Viewed by 26898 | Submission Open

Keywords: retinal diseases; diagnosis; treatment; etiology; original article; review paper

(This special issue belongs to the Section Ophthalmology)

Recent Advances in Therapy of Trauma and Surgical Critical Care

edited by Rita Galeiras

submission deadline 20 Dec 2025 | 7 articles | Viewed by 24010 | Submission Open

Keywords: trauma management; trauma care; burn; critical care; damage control surgery; traumatic spinal cord injury

(This special issue belongs to the Section Emergency Medicine)

Sepsis and Organ Dysfunction: New Insights into Diagnosis and Treatment

edited by

Barbara Adamik

submission deadline 20 Dec 2025 | 10 articles | Viewed by 20895 | Submission Open

Keywords: intensive care; sepsis; septic shock; biomarkers; multiorgan dysfunction syndrome; ex-tracorporeal methods; mortality

(This special issue belongs to the Section Intensive Care)

Clinical Diagnosis and Management of Neonatal Diseases

edited by Ayala Gover and

Arieh Riskin

submission deadline 20 Dec 2025 | 10 articles | Viewed by 15956 | Submission Open

Keywords: newborn; preterm; neonatal intensive care; low birth weight; point-of-care ultrasound; neonatal monitoring

(This special issue belongs to the Section Clinical Pediatrics)

Substance and Behavioral Addictions: Prevention and Diagnosis

edited by

Icro Maremmani

submission deadline 20 Dec 2025 | 7 articles | Viewed by 15502 | Submission Open

Keywords: substance addiction; behavioural addiction; clinical perspectives; prevention strategies; diagnostic protocols; differential diagnosis; psychopathology of addiction; psychopathology as a diagnostic tool; craving behavioural covariates

(This special issue belongs to the Section Mental Health)

Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition)

edited by

Panagiotis Christopoulos

submission deadline 20 Dec 2025 | 5 articles | Viewed by 12578 | Submission Open

Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Thoracic Surgery: Current Challenges and Future Perspectives

edited by

Jon Zabaleta

and José Luis Campo-Cañaveral de la Cruz

submission deadline 20 Dec 2025 | 6 articles | Viewed by 11622 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Trauma and Acute Care Surgery Research: Innovations, Challenges, and Future Directions

edited by Frederick Rogers

submission deadline 20 Dec 2025 | 7 articles | Viewed by 11527 | Submission Open

Keywords: trauma care; best practices; clinical care; trauma system development; optimal trauma care

(This special issue belongs to the Section Intensive Care)

State-of-the-Art Innovations in Oral and Maxillofacial Surgery

edited by Marcin Kozakiewicz and Katarzyna Bogusiak

submission deadline 20 Dec 2025 | 8 articles | Viewed by 11155 | Submission Open

Keywords: oral surgery; maxillofacial surgery; traumatology; orthognatic surgery; infections; oncology; diagnostics; treatment; implantology; augmentation; imaging; computer-assisted techniques

(This special issue belongs to the Section Otolaryngology)

Advances in Trauma Care and Emergency Medicine

edited by

Lothar Andreas Schwarte

Patrick Schober

and

Georgios F. Giannakopoulos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 10343 | Submission Open

Keywords: trauma; trauma care; emergency medicine; pre-hospital; emergency room; intensive care unit

(This special issue belongs to the Section Emergency Medicine)

Advances in Leveraging Big Data for Improving Patient Outcomes in Gastrointestinal and Hepatopancreatobiliary Diseases

edited by Saurabh Chawla

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9869 | Submission Open

Keywords: big data; machine learning; artificial intelligence; gastroenterology; research; hepatopancreatobiliary

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Surgical Treatment and Postoperative Recovery of Heart and Lung Disease

edited by

Yasushige Shingu

submission deadline 20 Dec 2025 | 6 articles | Viewed by 8981 | Submission Open

Keywords: heart and lung disease; complications; frailty; rehabilitation; atrial fibrillation; infections

(This special issue belongs to the Section Cardiovascular Medicine)

Diagnosis and Treatment of Rheumatic Diseases

edited by Răzvan Gabriel Drăgoi and

Codrina Ancuta

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8066 | Submission Open

Keywords: rheumatic diseases; patient-reported outcomes; assessment; arthritis; impairment; connective tissue diseases; biological and targeted synthetic therapies; impairment

(This special issue belongs to the Section Immunology & Rheumatology)

New Advances in Extracorporeal Membrane Oxygenation (ECMO)

edited by Camilla L'Acqua

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7992 | Submission Open

Keywords: ECMO; anticoagulation; circuit; global collaboration

(This special issue belongs to the Section Emergency Medicine)

New Insights in Ophthalmic Surgery

edited by Irina S. Barequet

submission deadline 20 Dec 2025 | 8 articles | Viewed by 7869 | Submission Open

Keywords: cataract surgery; corneal surgery; refractive surgery; ocular surface reconstruction; anterior segment surgery

(This special issue belongs to the Section Ophthalmology)

Pelvic Organ Prolapse: Current Challenges and Future Perspectives

edited by Marco Soligo

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7512 | Submission Open

Keywords: pelvic organ prolapse; urinary incontinence; lower urinary disorders; quality of life; patient-reported outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Patient Reported Outcomes (PROs) in Inflammatory Bowel Disease (IBD) Around the World

edited by Irina Blumenstein

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7180 | Submission Open

Keywords: inflammatory bowel disease; patient reported outcomes; symptom burden; quality of life; treatment satisfaction

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Perspectives on Congenital Heart Disease from Children to Adults

edited by

Raffaele Giordano

submission deadline 20 Dec 2025 | 4 articles | Viewed by 6783 | Submission Open

Keywords: congenital heart disease; pediatric cardiac surgery; pediatric cardiology; children; adult congenital heart disease

(This special issue belongs to the Section Cardiology)

Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Hirsh D. Trivedi

submission deadline 20 Dec 2025 | 5 articles | Viewed by 6759 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease; MASLD; non-alcoholic fatty liver disease; NAFLD; liver disease; liver fibrosis; metabolic syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Treatment and Management of Rheumatic Diseases, Autoinflammatory Diseases, and Autoimmune Disorders

edited by Merav Lidar and

Abdulla Watad

submission deadline 20 Dec 2025 | 6 articles | Viewed by 6669 | Submission Open

Keywords: rheumatic diseases; autoinflammatory diseases; autoimmune disorders; rheumatoid arthritis; diagnosis

(This special issue belongs to the Section Immunology & Rheumatology)

Robotic Bariatric Surgery

edited by

Antonio Vitiello

and Vincenzo Pilone

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5983 | Submission Open

Keywords: bariatric surgery; metabolic surgery; sleeve gastrectomy; bariatrics; general surgery; gastric bypass; robotic surgery; robotics

(This special issue belongs to the Section General Surgery)

State of the Art in Hand Surgery

edited by Leszek Romanowski and

Piotr Czarnecki

submission deadline 20 Dec 2025 | 5 articles | Viewed by 5506 | Submission Open

Keywords: hand surgery; nerve surgery; state-of-the-art; hand therapy; tendons; thumb arthritis; hand fractures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Emergency Ultrasound: State of the Art and Perspectives

edited by

Yale Tung-Chen

and

Gonzalo Garcia Casasola

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5140 | Submission Open

Keywords: point-of-care ultrasound; emergency ultrasound; focus cardiac ultrasound; lung ultrasound; shock; venous thromboembolic disease; systemic venous congestion; resuscitation; polytrauma

(This special issue belongs to the Section Emergency Medicine)

Latest Advances in Orthodontics

edited by

Giuseppina Laganà

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4965 | Submission Open

Keywords: digital treatment planning; clear aligners; skeletal anchorage; OSAS; artificial intelligence

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights

edited by

Shinichi Watanabe

Nobuto Nakanishi

and

Yuki Iida

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4329 | Submission Open

Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Perspectives on Acute Coronary Syndrome

edited by

Marius Rus

and

Massimo Mancone

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4324 | Submission Open

Keywords: acute coronary syndrome; ischemic heart disease; multidisciplinary approach; interventional cardiology; new research lines; diagnosis and risk stratification; biomarkers; reperfusion strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Accelerating Fracture Healing: Clinical Diagnosis and Treatment

edited by Seong-Eun Byun

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4121 | Submission Open

Keywords: fracture; fracture surgery; fracture healing; diagnosis; treatment

(This special issue belongs to the Section Orthopedics)

Displaying special issue 201-250 on page 5 of 31.

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