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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Fertility Preservation

edited by Dunja Maria Baston-Büst

submission deadline 25 Nov 2025 | 1 articles | Viewed by 1045 | Submission Open

Keywords: fertility preservation; gonadotoxic treatment; chemotherapy; transgender; cryopreservation; ejaculate; testicular tissue; mature oocytes; immature oocytes; ovarian tissue; ovarian cortex

(This special issue belongs to the Section Obstetrics & Gynecology)

Emerging Treatment Options in Aortic Valve Disease and Aortic Stenosis

edited by Borut Geršak and Robert Phillip Gallegos

submission deadline 25 Nov 2025 | 1 articles | Viewed by 962 | Submission Open

Keywords: aortic stenosis; minimally invasive surgery; transcatheter aortic valve replacement; surgical treatment; diagnostic strategies; re-operation/redo AVR; calcified root; valve in valve

(This special issue belongs to the Section Cardiology)

Approaches and Challenges in Oral Rehabilitation

edited by

Yoko Hasegawa

and Takayuki Kosaka

submission deadline 25 Nov 2025 | 1 articles | Viewed by 959 | Submission Open

Keywords: oral rehabilitation; oral health; systemic health; dental innovation; neuroplasticity

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Advances in Adverse Pregnancy and Neonatal Outcomes

edited by

Sae-kyung Choi

submission deadline 25 Nov 2025 | 1 articles | Viewed by 912 | Submission Open

Keywords: maternal and fetal; adverse pregnancy; neonatal outcomes; newborns; cesarean section

(This special issue belongs to the Section Obstetrics & Gynecology)

Endometriosis: Current Insights and Treatments

edited by Mercedes Espada Vaquero

submission deadline 25 Nov 2025 | 1 articles | Viewed by 469 | Submission Open

Keywords: endometriosis; chronic pelvic pain; pelvic floor dysfunction; hormonal treatment; gynecological surgery; diagnosis; hysteroscopy; infertility

(This special issue belongs to the Section Obstetrics & Gynecology)

Ischemic Stroke: Diagnosis, Treatment, and Management

edited by

Maria Luisa Zedde

and Rosario Pascarella

submission deadline 25 Nov 2025 | Viewed by 426 | Submission Open

Keywords: ischemic stroke; diagnosis; treatment; stroke unit; stroke care; stroke etiology; thrombolysis; EVT; rare causes of stroke; cerebral vein thrombosis

(This special issue belongs to the Section Clinical Neurology)

New Insights in Paediatric Endocrinology

edited by

Marco Fiore

submission deadline 25 Nov 2025 | 1 articles | Viewed by 374 | Submission Open

Keywords: endocrinology; pediatrics; hormones; therapy and treatment; adolescents; newborns

(This special issue belongs to the Section Clinical Pediatrics)

Interstitial Lung Diseases: New Treatments Based on Treatable Traits

edited by Francesco Amati

submission deadline 25 Nov 2025 | Viewed by 240 | Submission Open

Keywords: interstitial lung diseases; progressive pulmonary fibrosis; phenotypes; endotypes; treatment; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Recent Advances in Diagnosis and Treatment of Comorbid Disorders in Interstitial Lung Diseases

edited by

Giacomo Sica

and Domenica Francesca Mariniello

submission deadline 25 Nov 2025 | Viewed by 228 | Submission Open

Keywords: interstitial lung disease; ILD; progressive pulmonary fibrosis; artificial intelligence; management

(This special issue belongs to the Section Respiratory Medicine)

Enhancing Safety and Outcomes in Complex Spine Surgery

edited by Ahmed Ramadan Sadek

submission deadline 25 Nov 2025 | Viewed by 222 | Submission Open

Keywords: spinal surgery; spinal deformity; scoliosis; sciatica; back and neck pain

(This special issue belongs to the Section Clinical Neurology)

New Horizons in Aortic Valve Replacement

edited by Abdellaziz Dahou

submission deadline 25 Nov 2025 | Viewed by 181 | Submission Open

Keywords: aortic valve; aortic stenosis; TAVR; SAVR; valve durability; aortic valve replacement; transcatheter aortic valve replacement; surgical aortic valve replacement

(This special issue belongs to the Section Cardiology)

Advances in Ablation Therapy for Atrial Fibrillation: Innovations and Clinical Applications

edited by Ioanna Koniari

submission deadline 25 Nov 2025 | Viewed by 169 | Submission Open

Keywords: atrial fibrillation; ablation; PFA; PVI; non-thermal energy; mapping system

(This special issue belongs to the Section Cardiology)

Ventricular Assist Devices: Clinical Advances in Practice and Future Perspectives

edited by Balakrishnan M. Mahesh

submission deadline 25 Nov 2025 | Viewed by 165 | Submission Open

Keywords: ventricular assist device; mechanical circulatory support; pulsatile pneumatic devices; microaxial intraventricular de-vices; magnetically levitated devices; cardiac transplantation; donor circulatory death; normothermic regional perfusion

(This special issue belongs to the Section Cardiology)

The Use of Circulating Extracellular Vesicles as a Tool in the Diagnosis, Monitoring and Treatment of Disease

edited by

Antonio Casado-Díaz

submission deadline 25 Nov 2025 | Viewed by 162 | Submission Open

Keywords: circulating extracellular vesicles; regenerative medicine; biomarker; diagnosis; exosomes; liquid biopsy

(This special issue belongs to the Section Clinical Laboratory Medicine)

Minimally Invasive Laparoendoscopic Procedures in Abdominal Emergencies

edited by

Eugen Tãrcoveanu

Costel Bradea

and

Alin Mihai Vasilescu

submission deadline 25 Nov 2025 | Viewed by 138 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; minimally invasive surgery; hepatobiliary surgery; pancreatic surgery; gastrointestinal surgery; general surgery; emergency surgery; trauma; recent advances in laparoscopic surgery; surgical training in laparoscopy; endoscopic surgery; the feasibility and safety of laparoscopic; endoscopic co-operative surgery for the treatment of digestive pathology

(This special issue belongs to the Section General Surgery)

Treatment and Digital Outcome Assessment in Orthopaedic Trauma

edited by Benedikt Johannes Braun and

Meir Tibi Marmor

submission deadline 25 Nov 2025 | Viewed by 125 | Submission Open

Keywords: orthopaedic trauma; digital outcome assessment; wearable sensors; patient-reported outcomes; machine learning (or artificial intelligence)

(This special issue belongs to the Section Orthopedics)

New Approaches in Open and Minimally Invasive Surgery for Abdominal Oncologic Surgery

edited by

Alessandro Coppola

and Immacolata Iannone

submission deadline 25 Nov 2025 | Viewed by 117 | Submission Open

Keywords: surgical oncology; early diagnosis; minimally invasive surgery; personalized medicine; combined therapy; gastrointestinal cancer; oligometastatic cancer; peritoneal disease

(This special issue belongs to the Section General Surgery)

Clinical Innovation in Endoscopic Sinus and Anterior Skull Base Surgery

edited by

Samiul Muquit

and

Marios Stavrakas

submission deadline 27 Nov 2025 | Viewed by 165 | Submission Open

Keywords: rhinology; endoscopic anterior skull base surgery; anterior skull base surgery; endoscopic sinus surgery; chronic rhinosinusitis (CRS); otolaryngology

(This special issue belongs to the Section Otolaryngology)

Management of Complex Infective Endocarditis

edited by Shekhar Saha, Tulio Caldonazo and Mateo Marin-Cuartas

submission deadline 27 Nov 2025 | Viewed by 109 | Submission Open

Keywords: infective endocarditis; imaging; diagnosis; cardiac surgery; pathogens; antibiotic treatment; risk estimation

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis and Management of Age-Related Macular Degeneration: 2nd Edition

edited by Tsutomu Yasukawa

submission deadline 28 Nov 2025 | 8 articles | Viewed by 10288 | Submission Open

Keywords: age-related macular degeneration; angiography; antivascular endothelial growth factor therapy; choroidal neovascularization; geographic atrophy; multimodal imaging; ophthalmology; optical coherence tomography; photodynamic therapy; retinal pigment epithelium

(This special issue belongs to the Section Ophthalmology)

New Trends in Mechanical Ventilation

edited by

Jan P. Mulier

submission deadline 28 Nov 2025 | 2 articles | Viewed by 7099 | Submission Open

Keywords: positive pressure ventilation; negative pressure ventilation; constant flow ventilation; PEEP; lung recruitment; obesity; laparoscopy; ARDS; atelectasis; total lung compliance

(This special issue belongs to the Section Anesthesiology)

Advances in Spine Surgery: Best Practices and Future Directions

edited by Martin N. Stienen and

Stefan Motov

submission deadline 28 Nov 2025 | 6 articles | Viewed by 6364 | Submission Open

Keywords: minimally invasive spine surgery; spinal endoscopy; spinal robotics; spinal navigation; ERAS; machine learning; artificial intelligence; complication management; revision surgery; spinal deformity; innovation; future direction

(This special issue belongs to the Section Clinical Neurology)

Current Practices in Cardiovascular Perfusion and Recovery

edited by

Irbaz Hameed

submission deadline 28 Nov 2025 | 1 articles | Viewed by 2432 | Submission Open

Keywords: organ perfusion; ex vivo perfusion; ischemia– reperfusion injury; organ recovery; transplantation; machine perfusion; organ preservation

(This special issue belongs to the Section Cardiology)

Advancements in Anterior Cruciate Ligament Injury: From Diagnosis to the Return-to-Sports: 2nd Edition

edited by Alexandre Hardy and Nicolas Bouguennec

submission deadline 28 Nov 2025 | 3 articles | Viewed by 2171 | Submission Open

Keywords: anterior cruciate ligament reconstruction (ACLR); timing of ACLR; ramp lesion; meniscal lesion; lateral extra-articular procedure

(This special issue belongs to the Section Sports Medicine)

Clinical Updates in Heart Transplantation

edited by

Giacomo Bianchi

submission deadline 28 Nov 2025 | 2 articles | Viewed by 1480 | Submission Open

Keywords: heart transplantation; ex vivo heart preservation; immunosuppression; xenotransplantation; pre-clinical models; dilated cardiomyopathy; amyloidosis; congenital heart disease

(This special issue belongs to the Section Cardiology)

Innovations in Thoracic Surgery and Disease Management: Integrating Genomics, Technology, and Multidisciplinary Care

edited by

Marco Scarci

and

Savvas Lampridis

submission deadline 28 Nov 2025 | Viewed by 245 | Submission Open

Keywords: thoracic surgery; thoracic disease; genomic medicine; artificial intelligence; advanced imaging; multidisciplinary care; minimally invasive surgery; robotic surgery; precision medicine

(This special issue belongs to the Section Respiratory Medicine)

Novel Treatments for Vestibular Migraine

edited by

Teru Kamogashira

submission deadline 28 Nov 2025 | Viewed by 196 | Submission Open

Keywords: neuromodulation therapy; sympathetic nerve stimulation; CGRP-targeted therapy; dietary interventions; elimination diets; ketogenic diet; low-glycemic index diet; nutritional supplements; pathophysiology of vestibular migraine; clinical adoption of VM therapies

(This special issue belongs to the Section Otolaryngology)

State of the Art in Hepato-Pancreato-Biliary (HPB) Surgery

edited by

Pantelis Antonakis

and Konstantinos Bramis

submission deadline 28 Nov 2025 | Viewed by 167 | Submission Open

Keywords: hepato-pancreato-biliary (HPB) surgery; robotic surgery; laparoscopic surgery; liver resection; liver transplantation; pancreatectomy; liver thermoablation; extrahepatic cholangiocarcinoma; benign biliary disease; pancreatic neuroendocrine tumors; non-colorectal/non-neuroendocrine oligometastatic liver disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Novel Diagnostic and Therapeutic Opportunities in Inflammatory and Oncological Diseases in the Gastrointestinal Tract

edited by

Adam Fabisiak

and Hubert Zatorski

submission deadline 28 Nov 2025 | Viewed by 128 | Submission Open

Keywords: cancer; inflammation; diagnosis; treatment; microbiota; gastrointestinal tract; gastroenterology; immunology

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

New Challenges in Maternal-Fetal Medicine

edited by Marzena Laskowska

submission deadline 29 Nov 2025 | 7 articles | Viewed by 15101 | Submission Open

Keywords: thrombocytopenia in pregnancy; multiple pregnancies; placental abruption; DIC; sepsis; chorioamnionitis; cholestasis; postpartum hemorrhage; emergency cervical cerclage; problems in pregnancy and labor; pregnancy complications; spina bifida; fetal well-being evaluation

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Advances in Critical Care Medicine

edited by Pietro Caironi

submission deadline 30 Nov 2025 | 14 articles | Viewed by 46970 | Submission Open

Keywords: critical care; artificial intelligence; extra-corporeal life support; mechanical ventilation; sepsis; infection; airway management; acute kidney injury; biomarkers; trauma

(This special issue belongs to the Section Intensive Care)

Bruxism and Temporomandibular Disorders: Current Advances and Future Challenges

edited by

Grzegorz Zieliński

and

Eiji Tanaka

submission deadline 30 Nov 2025 | 22 articles | Viewed by 41052 | Submission Open

Keywords: TMDs; TMJ; rehabilitation; physiotherapy; craniofacial disorder; oral health; biomechanics; masticatory muscles; electromyography; parafunction; nocturnal bruxism; tooth contact habit

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Recent Advances in Reconstructive Urology and Prosthetic Surgery

edited by Francisco E. Martins, Maurice Garcia and Jay Simhan

submission deadline 30 Nov 2025 | 4 articles | Viewed by 14799 | Submission Open

Keywords: male and female urogenital reconstruction; urologic trauma; urologic prosthetics; erectile dysfunction; urinary incontinence; artificial urinary sphincter; gender-affirming surgery; transgender; phalloplasty; vaginoplasty

(This special issue belongs to the Section Nephrology & Urology)

What’s New in Cardiomyopathies: Diagnosis, Treatment and Management

edited by

Cinzia Forleo

submission deadline 30 Nov 2025 | 6 articles | Viewed by 14092 | Submission Open

Keywords: cardiomyopathies; multimodality imaging; cardiac magnetic resonance; genetic testing; cardiogenetics; genetic cardiovascular disease; rare cardiovascular diseases

(This special issue belongs to the Section Cardiology)

Advancements in Cornea Transplantation

edited by Giulia Coco and Davide Romano

submission deadline 30 Nov 2025 | 8 articles | Viewed by 11035 | Submission Open

Keywords: corneal transplant; keratoplasty; DMEK; DSAEK; PK; cornea

(This special issue belongs to the Section Ophthalmology)

Maxillo-Facial Surgery: New Insights and Technologies in Head and Neck

edited by Federica Ruggiero

submission deadline 30 Nov 2025 | 6 articles | Viewed by 10409 | Submission Open

Keywords: oral and maxilla-facial surgery; orthognathic surgery; cranio-facial surgery; head and neck surgery; augmented reality; navigation; finite element modeling; virtual surgical planning; patient-specific implants

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Pediatric Dentistry: Recent Advances, Current Issues and Future Challenges

edited by

Liliana Szyszka-Sommerfeld

and

Krzysztof Woźniak

submission deadline 30 Nov 2025 | 6 articles | Viewed by 10288 | Submission Open

Keywords: pediatric dentistry; recent advances; current issues; future challenges; orthodontic issues; preventive strategies; access to care disparities; behavioral management; multidisciplinary collaboration; oral health

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Personalized Risk Stratification with Diagnostic and Prognostic Relevance for Coronary Artery Disease: New Challenges and Opportunities in a New Era

edited by

Georgios I. Tagarakis

submission deadline 30 Nov 2025 | 4 articles | Viewed by 8906 | Submission Open

Keywords: coronary artery disease; cardiovascular prevention; risk stratification; cardiovascular pathology

(This special issue belongs to the Section Cardiovascular Medicine)

Oral and Maxillofacial Surgery: Diagnosis, Management and Future Opportunities

edited by

Federico Gelpi

submission deadline 30 Nov 2025 | 5 articles | Viewed by 7598 | Submission Open

Keywords: head and neck oncology; free flaps; oral surgery; malformative surgery; traumatology; endoscopy; preprosthetic surgery; reconstructive surgery; vascular malformations; osteonecrosis

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Therapy of Trauma and Surgical Critical Care

edited by Rabail Chaudhry and George W. Williams

submission deadline 30 Nov 2025 | 2 articles | Viewed by 7260 | Submission Open

Keywords: regional anesthesia; critical care; trauma resuscitation; transfusion strategies; thermal injury; obstetric critical care; epitheliopathy; metabolomics; ICU pain management; trauma care subpopulations

(This special issue belongs to the Section Intensive Care)

New Insights into Cardiovascular and Minimally Invasive Cardiac Surgery

edited by Parwis Massoudy and Hilmar C. Dörge

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6968 | Submission Open

Keywords: coronary artery bypass grafting; aortic valve surgery; mitral valve surgery; aortic surgery; minimally invasive cardiac surgery

(This special issue belongs to the Section Cardiology)

Recent Progress in Rehabilitation Medicine—3rd Edition

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 3 articles | Viewed by 6938 | Submission Open

Keywords: neuro-rehabilitation; cognitive rehabilitation; spinal rehabilitation; orthopedic rehabilitation; pediatric rehabilitation; cancer rehabilitation; visceral rehabilitation; cardiac rehabilitation; pulmonary rehabilitation; renal rehabilitation; hepatic rehabilitation; rehabilitation for transplantation; fitness; peak VO2; multimorbidity and multiple disabilities (MMD); adding life to years and years to life

(This special issue belongs to the Section Clinical Rehabilitation)

Ischemic Stroke: Diagnosis and Treatment

edited by

Theodoros Karapanayiotides

and

Ioanna Koutroulou

submission deadline 30 Nov 2025 | 4 articles | Viewed by 6457 | Submission Open

Keywords: stroke; reperfusion therapies; neuroimaging; brain ischemia; intracerebral hemorrhage; intravenous thrombolysis; mechanical thrombectomy

(This special issue belongs to the Section Clinical Neurology)

Cardiac Arrhythmias: Recent Advances in Underlying Mechanisms, Diagnostic Options and Therapeutic Approaches

edited by Elisabeth M.J.P. Mouws and

Natasja de Groot

submission deadline 30 Nov 2025 | 5 articles | Viewed by 6203 | Submission Open

Keywords: cardiac arrhythmia; atrial fibrillation; congenital heart disease; underlying mechanisms; therapeutic options

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis and Treatment of Ocular Surface Tumors and Diseases

edited by Sotiria Palioura, Carolina L. Mercado and

Jaime D. Martinez

submission deadline 30 Nov 2025 | 2 articles | Viewed by 4796 | Submission Open

Keywords: ocular surface diseases; anterior segment imaging; chemotherapeutics; immunomodulatory agents; minimally invasive surgical techniques

(This special issue belongs to the Section Ophthalmology)

Clinical Research and Personalized Medicine in Inflammatory Bowel Disease

edited by

Alfredo Papa

and Loris Riccardo Lopetuso

submission deadline 30 Nov 2025 | 4 articles | Viewed by 3713 | Submission Open

Keywords: inflammatory bowel disease (IBD); personalized medicine; precision medicine; Crohn’ s disease; ulcerative colitis; targeted therapy; artificial intelligence

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Integrated Clinical Approaches to Managing Multimorbidity and Multiple Disabilities: Advances in Rehabilitation and Therapeutic Strategies

edited by

Masahiro Kohzuki

submission deadline 30 Nov 2025 | 2 articles | Viewed by 3146 | Submission Open

Keywords: heart; lung; kidney; liver; bone; brain

(This special issue belongs to the Section Clinical Rehabilitation)

Assisted Reproductive Technology and Infertility Treatment: Current Updates and Perspectives—2nd Edition

edited by Nikos Nikolettos and

Angeliki Tiptiri-Kourpeti

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2451 | Submission Open

Keywords: assisted reproduction technology (ART); infertility; treatment; reproduction; IVF

(This special issue belongs to the Section Reproductive Medicine & Andrology)

Clinical Updates on Prosthodontics

edited by

Rubén Agustín Panadero

and Carla Fons-Badal

submission deadline 30 Nov 2025 | 2 articles | Viewed by 2336 | Submission Open

Keywords: dental prosthesis; dental implants; gingival treatment; gingival aesthetics; gingival treatment; dental aesthetics; dental ceramics; BOPT; surgical periodontal treatment

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances of Breast Surgery and Reconstruction

edited by

Glenda Giorgia Caputo

and Emanuele Cigna

submission deadline 30 Nov 2025 | 1 articles | Viewed by 1965 | Submission Open

Keywords: breast reconstruction; autologous breast reconstruction; implant-based breast reconstruction; DIEP; LICAP; breast implant infection

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

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