Dear Colleagues,               

Cells of the liver vasculature play an essential role in the pathophysiology of acute and chronic liver diseases, and therefore are considered key therapeutic targets for the treatment of most human hepatopathies. Indeed, in recent decades, we have markedly advanced our understanding of the phenotypic changes which occur in liver vascular cells in front of an injury, which allows one to describe how cells contribute to the development of microcirculatory dysfunction, fibrosis, inflammation, cirrhosis, and liver failure.

The aim of this Special Issue is to provide a state-of-the-art review of recent advances in liver vascular pathobiology, with a particular emphasis on liver vascular disease pathophysiology, novel mechanisms, unmet clinical questions, the development of biomarkers, and treatment opportunities. Translational researchers and clinical scientists are welcomed to submit their latest works, that will contribute to the further understanding of liver vascular disease and hepatic fibrosis.

Topics will include:

• Liver endothelium and fibrosis
• Epidemiology of liver vascular disease
• Natural history of vascular liver disease
• Pathophysiology of liver vascular disease
• Invasive and non-invasive diagnosis
• Liver histology and vascular disease
• Prognostic factors and markers of disease progression
• Management of portal hypertension in liver vascular disease
• Novel therapeutics for liver vascular disease
• Novel interventions for liver vascular disease
• Future directions in the field, including novel methods and omics data

Dr. Jordi Gracia-Sancho
Dr. Virginia Hernández-Gea
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Acute liver injury
• Ischemia reperfusion injury
• Chronic liver disease/cirrhosis
• NAFLD/MAFLD
• NASH/MASH
• ALD
• Budd–Chiari syndrome
• Portal vein thrombosis
• Portosinusoidal vascular disease/idiopathic portal hypertension
• Liver hemodynamics
• HVPG
• TIPS
• Anticoagulation
• Sinusoidal obstruction syndrome
• Portal hypertension
• Liver sinusoidal endothelial cells
• Hepatic stellate cells
• Noninvasive methods of diagnosis and prognosis
• Novel therapeutics
• Clinical trials