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Special Issue "Disentangling Clinical and Biological Heterogeneity in Huntington’s Disease: Implications for Clinical Trials"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nuclear Medicine & Radiology".
Deadline for manuscript submissions: 15 April 2023 | Viewed by 766
Special Issue Editor
Interests: radiology; neuroimaging; data science; neurodegenerative diseases; biomarkers
Special Issue Information
Huntington’s disease (HD) experience progressive motor, cognitive and neuropsychiatric symptoms that lead to a devastating loss of functional independence. However, there is substantial heterogeneity across HD patients regarding the longitudinal evolution of these symptoms. Some of them show cognitive predominance, others neuropsychiatric, and some of them will only experience motor symptoms until a late disease stage. Being able to characterize and predict this clinical heterogeneity is crucial to optimize treatment strategies. For that, neuroimaging and biomarker research is needed to better understand the origin of these divergent phenotypes. This issue will focus on delineating the set of clinical, neuroimaging and biomarker profiles of HD patients. Moreover, we will aim to provide practical tools to classify HD patients in clinical trials targeting both motor and non-motor symptoms.
Dr. Frederic Sampedro
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Huntington’s disease
- Non-motor symptoms
- Phenotype heterogeneity