Special Issue "New Insights into Neurophysiology and Neuroimaging of Movement Disorders"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Clinical Neurology".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 3440
Special Issue Editor
Interests: clinical neurophysiology; movement disorders; imaging
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Movement disorders can be studied by clinical neurophysiology and neuroimaging techniques. Utilizing and understanding electrophysiology and multimodal imaging is crucial to provide an accurate early diagnosis of distinct movement disorders, enhance our understanding of their pathophysiological mechanisms, and provide both invasive and non-invasive treatment options.
This Special Issue will focus on electrophysiological aspects of tremor, dystonia, myoclonus, parkinsonism, and functional movement disorders. It will show how electrophysiology can help clinicians diagnose distinct movement disorders and enhance understanding of their pathological mechanisms and treatment effects and options.
The advanced stage of idiopathic Parkinson’s disease (PD) is often characterized by gait alterations and postural instability. There is an unmet need for further symptomatic therapeutic strategies, particularly as gait disturbances generally respond unfavorably to dopaminergic medication and conventional deep brain stimulation of the subthalamic nucleus in advanced disease stages. Recent pathophysiological research pointed to nigro-pontine networks entrained to locomotor integration. The substantia nigra pars reticulata - entrained into integrative locomotor networks - is pathologically overactive in PD. High-frequent stimulation of the substantia nigra pars reticulata preferentially modulated axial symptoms and therefore is suggested as a novel therapeutic candidate target for neuromodulation of refractory gait disturbances in PD.
Novel deep brain stimulation (DBS) lead designs are currently entering the market, which are hypothesized to provide a way to steer the stimulation field away from neural populations responsible for side effects and towards populations responsible for beneficial effects. To target "sweet spots" for stimulation, neuroimaging tools are mandatory. There is an interest whether a Brain Atlas is applicable for the visualization of stimulation sites. For postoperative documentation, stimulation sites in individual patients can be projected on an atlas. There are a number of two-dimensional atlases that use the intercommissural line as a reference. In a different approach, a high-resolution, three-dimensional model of thalamic and subthalamic structures (3D-Morel Atlas) was recently constructed by combining information contained in histological data from ten post-mortem brains.
Overall, the main goal of this Special Issue is a comprehensive overview of the state-of-the-art on this important research field.
Dr. Ignacio Regidor Bailly-Bailliere
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- Movement disorders
- clinical neurophysiology
- neuroimaging techniques
- electrophysiology
- multimodal imaging
- Neuromodulation
- Novel deep brain stimulation
- neuronal activity
- gait disorders
- postural instability
