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Coronary Artery Disease: Recent Developments and Emerging Trends
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Coronary Artery Disease: Recent Developments and Emerging Trends

A Special Issue of Journal of Clinical Medicine (ISSN 2077-0383) belonging to the section "Cardiology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 1290

Editors

Prof. Dr. Attila Kardos

E-Mail Website
Guest Editor
1. Department of Cardiology, Translational Cardiovascular Research Group, Milton Keynes University Hospital NHS Foundation Trust, Milton Keynes, UK
2. Faculty of Medicine and Health Sciences, University of Buckingham, Buckingham, UK
Interests: integrated cardiovascular imaging; cardiac CT; echocardiography; CMR; coronary artery disease; ischemia; AI in cardiac image acquisition and analysis
Special Issues, Collections and Topics in MDPI journals
Dr. Tarun Mittal

E-Mail Website
Co-Guest Editor
1. Heart Division, Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London, UK
2. Faculty of Medicine, National Heart & Lung Institute, Imperial College London, London, UK
Interests: imaging of coronary heart disease; risk assessment; ventricular assist devices; heart failure; aortic valve disease; heart and lung transplantation

Special Issue Information

Dear Colleagues,

In this Special Issue, we would like to invite submissions related to all topics of coronary artery disease. The understanding of atherosclerosis from endothelial dysfunction through different stages of atherosclerotic plaques and plaque rupture leading to myocardial infarction has taken a huge leap in the last decade. With the developments of noninvasive cardiovascular imaging including advanced echocardiography with ultrasound enhancing agents and accurate detection of inducible wall motion abnormality, the Doppler assessment of coronary flow velocity reserve during stress echocardiography has brought diagnostics to the patient bedside. Advancement in non-invasive anatomical imaging of coronary arteries to detect congenital coronary anomalies, and coronary artery plaque features and burden have made Cardiac CT angiography an essential triaging tool for patients with suspected coronary artery disease. The AI algorithm in detecting pathophysiological changes indicative of vascular inflammation surrounding the coronary arteries, which in spite of non-occlusive plaque disease have the potential of predicting MACE outcome, is an intriguing development that needs further exploration in routine clinical practice. Noninvasive testing for angina with non-occlusive coronary artery disease remains a huge challenge to the cardiac community. To develop entirely non-invasive testing for all ANOCA endotypes is one of our future tasks. Therefore, we encourage you to submit your manuscripts to this Special Issue, which can range from basic research to works on all diagnostic modalities (echocardiography, Cardiac CT angiography, Cardiac MRI) and invasive coronary physiological testing, to contribute to the dissemination of the latest research on risk stratification, modelling and all types of therapies that improve patients’ symptoms and outcomes via regressing or stabilizing coronary pathophysiological processes.

Prof. Dr. Attila Kardos
Dr. Tarun Mittal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coronary atherosclerosis
  • diagnostic strategies
  • therapeutic options
  • timing of intervention
  • artificial intelligence
  • novel therapeutic pathways

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

18 pages, 943 KB  
Article
Inflammatory Response After Elective PCI and Subsequent Outcomes in Stable Coronary Artery Disease
by Yalcin Dalgic, Osman Muhsin Celik, Sadiye Nur Dalgic, Furkan Gencer, Mutlu Can Kabaci, Servet Batit, Aziz Inan Celik, Sabiye Yilmaz, Metin Cagdas, Ayhan Erkol and Burak Turan
J. Clin. Med. 2026, 15(17), 6557; https://doi.org/10.3390/jcm15176557 - 25 Aug 2026
Viewed by 246
Abstract
Background/Objectives: Inflammation contributes to atherosclerotic progression and may intensify after percutaneous coronary intervention (PCI). In stable coronary artery disease (CAD), whether post-procedural inflammation is prognostically distinct from baseline inflammatory status and post-procedural renal function remains unclear. Methods: We studied 496 consecutive patients with [...] Read more.
Background/Objectives: Inflammation contributes to atherosclerotic progression and may intensify after percutaneous coronary intervention (PCI). In stable coronary artery disease (CAD), whether post-procedural inflammation is prognostically distinct from baseline inflammatory status and post-procedural renal function remains unclear. Methods: We studied 496 consecutive patients with stable CAD undergoing elective PCI. The primary outcome was a composite of death, myocardial infarction, stroke, or repeat revascularization. Post-PCI high-sensitivity C-reactive protein (hs-CRP) and creatinine were measured 18–24 h after PCI. Multivariable Cox models used clinically prespecified covariates, with hs-CRP log-transformed (hazard ratio [HR] per doubling) and additionally adjusted for its pre-PCI level; discrimination was assessed by ROC analysis with bootstrap internal validation. Results: The endpoint occurred in 43 patients (8.7%) over a median follow-up of 10 months. Post-PCI hs-CRP was independently associated with the endpoint after adjustment for pre-PCI hs-CRP, post-PCI creatinine, and albumin (HR 1.43 per doubling, 95% CI 1.05–1.96, p = 0.025), and after further adjustment for angiographic and procedural characteristics (HR 1.54, p = 0.008); pre-PCI hs-CRP was not independent (p = 0.083). Post-PCI creatinine was independently associated in every model (HR 1.16 per 0.1 mg/dL, p = 0.001) and identified a largely non-overlapping high-risk group. Conclusions: After elective PCI in stable CAD, post-PCI hs-CRP was independently associated with adverse outcomes and provided prognostic information beyond baseline hs-CRP and procedural characteristics in the fitted models, rather than merely reflecting baseline inflammatory status. Post-PCI renal function was a complementary, largely independent risk signal. Full article
(This article belongs to the Special Issue Coronary Artery Disease: Recent Developments and Emerging Trends)
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15 pages, 476 KB  
Article
CXCL12 rs1801157 Polymorphism Is Associated with Antiatherogenic Lipoprotein Subfraction Profile Independent of Coronary Artery Disease Risk in a Turkish Population: A Case–Control Study
by İnci Deniz, Ayça Türer Cabbar, Fatma Tuba Akdeniz, Turgay İsbir and Seda Güleç Yılmaz
J. Clin. Med. 2026, 15(11), 4206; https://doi.org/10.3390/jcm15114206 - 29 May 2026
Viewed by 452
Abstract
Background/Objectives: Cardiovascular diseases remain a leading cause of global mortality. The C-X-C motif chemokine ligand 12 (CXCL12) gene has been implicated in atherosclerosis; however, its relationship with lipoprotein subfraction profiles remains unclear. The primary objective of this study was to investigate [...] Read more.
Background/Objectives: Cardiovascular diseases remain a leading cause of global mortality. The C-X-C motif chemokine ligand 12 (CXCL12) gene has been implicated in atherosclerosis; however, its relationship with lipoprotein subfraction profiles remains unclear. The primary objective of this study was to investigate the association between the CXCL12 rs1801157 C>T single nucleotide polymorphism (SNP) and coronary artery disease (CAD) risk in a Turkish population. The secondary objective was to evaluate the relationship between this polymorphism and LDL and HDL lipoprotein subfraction profiles. Methods: This case–control study included 139 patients with angiographically confirmed CAD and 125 healthy controls. Genotyping was performed using TaqMan real-time polymerase chain reaction (PCR). Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) subfractions were analyzed using the Lipoprint® polyacrylamide gel electrophoresis system. Multivariable logistic and linear regression analyses were performed, adjusting for age, sex, body mass index (BMI), and major cardiovascular risk factors. Results: No significant differences in rs1801157 genotype or allele distributions were observed between groups (overall χ2 = 0.459, p = 0.796). Logistic regression confirmed that the polymorphism was not an independent predictor of CAD risk (CT: OR = 1.396, p = 0.409; TT: OR = 1.458, p = 0.694). HDL-C was an independent protective factor (OR = 0.952, 95% CI: 0.910–0.996; p = 0.029). Notably, TT homozygous carriers exhibited significantly higher large HDL (p = 0.018) and intermediate HDL (p < 0.001) subfraction levels and markedly lower small LDL concentrations (p < 0.001). Multivariable linear regression confirmed these associations were independent of age, sex, and BMI. Conclusions: The CXCL12 rs1801157 variant does not directly influence CAD susceptibility but modulates lipoprotein quality by promoting larger HDL subfractions and reducing atherogenic small LDL particles, suggesting an indirect cardioprotective role through lipid metabolism. Full article
(This article belongs to the Special Issue Coronary Artery Disease: Recent Developments and Emerging Trends)
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